{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:51:30Z","timestamp":1790481090616,"version":"4.1.0"},"reference-count":90,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage. Properly functioning endothelial cells promote physiological balance and stability for blood circulation and fluid components. A monolayer of endothelial cells has the ability to regulate paracellular and transcellular pathways for transport proteins, solutes, and fluid. In addition to the paracellular pathway, the transcellular pathway is another route of endothelial permeability that mediates vascular permeability under physiologic conditions. The transcellular pathway was found to be associated with an assortment of disease pathogeneses. The clinical manifestation of severe dengue infection in humans is vascular leakage and hemorrhagic diatheses. This review explores and describes the transcellular pathway, which is an alternate route of vascular permeability during dengue infection that corresponds with the pathologic finding of intact tight junction. This pathway may be the route of albumin transport that causes endothelial dysfunction during dengue virus infection.<\/jats:p>","DOI":"10.3390\/v10020069","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T12:46:27Z","timestamp":1518180387000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection"],"prefix":"10.3390","volume":"10","author":[{"given":"Chanettee","family":"Chanthick","sequence":"first","affiliation":[{"name":"Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinay Medicine, Kasetsart University, Bangkok 10900, Thailand"},{"name":"Division of Molecular Medicine, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aroonroong","family":"Suttitheptumrong","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"},{"name":"Division of Molecular Medicine, Office for Research and Development, 4th Floor SiMR Building, 2 Wanglang Road, Faculty of Medicine Siriraj Hospital, Bangkoknoi, Bangkok 10700, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nantapon","family":"Rawarak","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa-nga","family":"Pattanakitsakul","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"},{"name":"Division of Molecular Medicine, Office for Research and Development, 4th Floor SiMR Building, 2 Wanglang Road, Faculty of Medicine Siriraj Hospital, Bangkoknoi, Bangkok 10700, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"ref_1","first-page":"67","article-title":"Markers of dengue disease severity","volume":"338","author":"Srikiatkhachorn","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/0019-5154.60357","article-title":"Dengue viral infections","volume":"55","author":"Gurugama","year":"2010","journal-title":"Indian J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1086\/651268","article-title":"Dengue hemorrhagic fever: The sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994\u20132005","volume":"50","author":"Srikiatkhachorn","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1160\/TH09-03-0208","article-title":"Plasma leakage in dengue haemorrhagic fever","volume":"102","author":"Srikiatkhachorn","year":"2009","journal-title":"Thromb. Haemost."},{"key":"ref_5","first-page":"711","article-title":"The cost of dengue hemorrhagic fever in Thailand","volume":"28","author":"Okanurak","year":"1997","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"ref_6","first-page":"1088","article-title":"Application of revised dengue classification criteria as a severity marker of dengue viral infection in Indonesia","volume":"41","author":"Basuki","year":"2010","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-065X.2008.00678.x","article-title":"Understanding the contribution of cellular immunity to dengue disease pathogenesis","volume":"225","author":"Mathew","year":"2008","journal-title":"Immunol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.3277268","article-title":"Pathogenesis of dengue: Challenges to molecular biology","volume":"239","author":"Halstead","year":"1988","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/01.qco.0000244047.31135.fa","article-title":"Immunopathological mechanisms in dengue and dengue hemorrhagic fever","volume":"19","author":"Green","year":"2006","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1743-422X-6-211","article-title":"The relationship of interacting immunological components in dengue pathogenesis","volume":"6","author":"Nielsen","year":"2009","journal-title":"Virol. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"444","DOI":"10.4269\/ajtmh.1989.40.444","article-title":"Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever","volume":"40","author":"Kliks","year":"1989","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/viro.2002.1704","article-title":"High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: Implications for pathogenesis","volume":"305","author":"Wang","year":"2003","journal-title":"Virology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1086\/340365","article-title":"Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections","volume":"185","author":"Libraty","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/nrmicro2460","article-title":"Dengue: A continuing global threat","volume":"8","author":"Guzman","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nm887","article-title":"Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever","volume":"9","author":"Mongkolsapaya","year":"2003","journal-title":"Nat. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cimid.2007.05.010","article-title":"Dengue hemorrhagic fever with special emphasis on immunopathogenesis","volume":"30","author":"Kurane","year":"2007","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1574-695X.2000.tb01474.x","article-title":"Cytokine cascade in dengue hemorrhagic fever: Implications for pathogenesis","volume":"28","author":"Chaturvedi","year":"2000","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1055\/s-0037-1612941","article-title":"The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome","volume":"87","author":"Suharti","year":"2002","journal-title":"Thromb. Haemost."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.4049\/jimmunol.161.11.6338","article-title":"Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis","volume":"161","author":"Avirutnan","year":"1998","journal-title":"J. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"I100","DOI":"10.1016\/j.vaccine.2008.11.061","article-title":"Complement and its role in protection and pathogenesis of flavivirus infections","volume":"26","author":"Avirutnan","year":"2008","journal-title":"Vaccine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1179\/136485910X12647085215778","article-title":"Whole-genome characterisation of Chikungunya virus from Aedes albopictus collected in Thailand","volume":"104","author":"Auksornkitti","year":"2010","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.00035-09","article-title":"Dengue virus pathogenesis: An integrated view","volume":"22","author":"Martina","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4269\/ajtmh.1990.42.179","article-title":"Dengue hemorrhagic fever in Cuba, 1981: A retrospective seroepidemiologic study","volume":"42","author":"Guzman","year":"1990","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/viro.1997.8504","article-title":"Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas","volume":"230","author":"Harrison","year":"1997","journal-title":"Virology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0140-6736(99)04015-5","article-title":"Failure of secondary infection with American genotype dengue 2 to cause dengue haemorrhagic fever","volume":"354","author":"Watts","year":"1999","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1152\/physrev.00012.2005","article-title":"Signaling mechanisms regulating endothelial permeability","volume":"86","author":"Mehta","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/3-540-32967-6_2","article-title":"Functional ultrastructure of the vascular endothelium: Changes in various pathologies","volume":"176","author":"Simionescu","year":"2006","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-pathol-012615-044506","article-title":"Disorders of vascular permeability","volume":"11","year":"2016","journal-title":"Ann. Rev. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10456-008-9099-z","article-title":"Vascular permeability, vascular hyperpermeability and angiogenesis","volume":"11","author":"Nagy","year":"2008","journal-title":"Angiogenesis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"L1081","DOI":"10.1152\/ajplung.00268.2004","article-title":"Integrated control of lung fluid balance","volume":"287","author":"Mehta","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/3-540-32967-6_4","article-title":"Transport across the endothelium: Regulation of endothelial permeability","volume":"176","author":"Minshall","year":"2006","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jemt.10086","article-title":"Transcytosis of plasma macromolecules in endothelial cells: A cell biological survey","volume":"57","author":"Simionescu","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"L823","DOI":"10.1152\/ajplung.00436.2006","article-title":"Molecular determinants of endothelial transcytosis and their role in endothelial permeability","volume":"293","author":"Predescu","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00418-001-0367-x","article-title":"Vesicle formation and trafficking in endothelial cells and regulation of endothelial barrier function","volume":"117","author":"Minshall","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"L895","DOI":"10.1152\/ajplung.00075.2004","article-title":"Functional and morphological studies of protein transcytosis in continuous endothelia","volume":"287","author":"Predescu","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_37","first-page":"932","article-title":"Albumen in health and disease: Protein metabolism and function","volume":"26","author":"Throop","year":"2004","journal-title":"Compend. Contin. Educ. Pract. Vet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00129804-200609000-00004","article-title":"The role of albumin in fluid and electrolyte balance","volume":"29","author":"Hankins","year":"2006","journal-title":"J. Infus. Nurs."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mvr.2008.10.002","article-title":"Regulation of transendothelial permeability by Src kinase","volume":"77","author":"Hu","year":"2009","journal-title":"Microvasc. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1016\/S0021-9258(17)37571-3","article-title":"Albondin-mediated capillary permeability to albumin. Differential role of receptors in endothelial transcytosis and endocytosis of native and modified albumins","volume":"269","author":"Schnitzer","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1073\/pnas.93.1.250","article-title":"Isolation and characterization of a cell surface albumin-binding protein from vascular endothelial cells","volume":"93","author":"Tiruppathi","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1161\/CIRCRESAHA.107.167486","article-title":"Intercellular adhesion molecule-1-dependent neutrophil adhesion to endothelial cells induces caveolae-mediated pulmonary vascular hyperpermeability","volume":"102","author":"Hu","year":"2008","journal-title":"Circ. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41232-017-0042-9","article-title":"Regulation of blood vascular permeability in the skin","volume":"37","author":"Ono","year":"2017","journal-title":"Inflamm. Regen."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/med.21270","article-title":"Myosin light chain kinase signaling in endothelial barrier dysfunction","volume":"33","author":"Rigor","year":"2013","journal-title":"Med. Res. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev-physiol-021909-135833","article-title":"Regulation of endothelial permeability via paracellular and transcellular transport pathways","volume":"72","author":"Komarova","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/03009734.2015.1064501","article-title":"Vascular permeability\u2014The essentials","volume":"120","year":"2015","journal-title":"Upsala J. Med. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ceca.2016.02.002","article-title":"ROS-activated calcium signaling mechanisms regulating endothelial barrier function","volume":"60","author":"Di","year":"2016","journal-title":"Cell Calcium"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/CIRCRESAHA.116.306534","article-title":"Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability","volume":"120","author":"Komarova","year":"2017","journal-title":"Circ. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/01.inf.0000258612.26743.10","article-title":"Natural history of plasma leakage in dengue hemorrhagic fever: A serial ultrasonographic study","volume":"26","author":"Srikiatkhachorn","year":"2007","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4269\/ajtmh.2007.77.291","article-title":"Chest radiographic presentation in patients with dengue hemorrhagic Fever","volume":"77","author":"Wang","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/00034983.1967.11686519","article-title":"Pathology of Thailand haemorrhagic fever: A study of 100 autopsy cases","volume":"61","author":"Bhamarapravati","year":"1967","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(06)69006-5","article-title":"The WHO dengue classification and case definitions: Time for a reassessment","volume":"368","author":"Deen","year":"2006","journal-title":"Lancet"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.cyto.2011.01.013","article-title":"Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability","volume":"54","author":"Chuang","year":"2011","journal-title":"Cytokine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.embor.7400814","article-title":"Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction","volume":"7","author":"Luplertlop","year":"2006","journal-title":"EMBO Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1099\/vir.0.82093-0","article-title":"MCP-1, a highly expressed chemokine in dengue haemorrhagic fever\/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells","volume":"87","author":"Lee","year":"2006","journal-title":"J. Gen. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"186","DOI":"10.7883\/yoken.JJID.2016.123","article-title":"Synergistic Effect of TNF-\u03b1 and Dengue Virus Infection on Adhesion Molecule Reorganization in Human Endothelial Cells","volume":"70","author":"Inyoo","year":"2017","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1099\/vir.0.19652-0","article-title":"IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers","volume":"85","author":"Talavera","year":"2004","journal-title":"J. Gen. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"298","DOI":"10.7883\/yoken.JJID.2008.298","article-title":"MMP cellular responses to dengue virus infection-induced vascular leakage","volume":"61","author":"Luplertlop","year":"2008","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1743-422X-6-49","article-title":"Profile of time-dependent VEGF upregulation in human pulmonary endothelial cells, HPMEC-ST1.6R infected with DENV-1, -2, -3, and -4 viruses","volume":"6","author":"Azizan","year":"2009","journal-title":"Virol. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1086\/599795","article-title":"Dengue virus infection differentially regulates endothelial barrier function over time through type I interferon effects","volume":"200","author":"Liu","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1099\/vir.0.83356-0","article-title":"Peripheral blood mononuclear cells increase the permeability of dengue virus-infected endothelial cells in association with downregulation of vascular endothelial cadherin","volume":"89","author":"Dewi","year":"2008","journal-title":"J. Gen. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1051\/ject\/201749174","article-title":"Endothelial glycocalyx and cardiopulmonary bypass","volume":"49","author":"Myers","year":"2017","journal-title":"J. Extra-Corpor. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.vph.2017.09.002","article-title":"Regulation and function of endothelial glycocalyx layer in vascular diseases","volume":"100","author":"Sieve","year":"2018","journal-title":"Vasc. Pharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"46191","DOI":"10.1038\/srep46191","article-title":"Increased serum hyaluronic acid and heparan sulfate in dengue fever: Association with plasma leakage and disease severity","volume":"7","author":"Tang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_65","first-page":"992","article-title":"Association of endothelial glycocalyx and tight and adherens junctions with severity of plasma leakage in dengue infection","volume":"215","author":"Suwarto","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Puerta-Guardo, H., Glasner, D.R., and Harris, E. (2016). Dengue virus NS1 disrupts the endothelial glycocalyx, leading to hyperpermeability. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005738"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Glasner, D.R., Ratnasiri, K., Puerta-Guardo, H., Espinosa, D.A., Beatty, P.R., and Harris, E. (2017). Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006673"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1021\/pr900060g","article-title":"Alterations in actin cytoskeletal assembly and junctional protein complexes in human endothelial cells induced by dengue virus infection and mimicry of leukocyte transendothelial migration","volume":"8","author":"Kanlaya","year":"2009","journal-title":"J. Proteom. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1021\/pr100357f","article-title":"Association of Alix with late endosomal lysobisphosphatidic acid is important for dengue virus infection in human endothelial cells","volume":"9","author":"Pattanakitsakul","year":"2010","journal-title":"J. Proteom. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S826","DOI":"10.1093\/clinids\/11.Supplement_4.S826","article-title":"Hemostatic defects in dengue hemorrhagic fever","volume":"11","author":"Bhamarapravati","year":"1989","journal-title":"Rev. Infect. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jcv.2007.04.024","article-title":"Apoptosis in tissues from fatal dengue shock syndrome","volume":"40","author":"Limonta","year":"2007","journal-title":"J. Clin. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cbi.2007.08.006","article-title":"Regulation of endothelial permeability by Src kinase signaling: Vascular leakage versus transcellular transport of drugs and macromolecules","volume":"171","author":"Hu","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00441-008-0682-9","article-title":"Src family kinases as mediators of endothelial permeability: Effects on inflammation and metastasis","volume":"335","author":"Kim","year":"2009","journal-title":"Cell Tissue Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"20392","DOI":"10.1074\/jbc.M308710200","article-title":"Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells","volume":"279","author":"Shajahan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"25968","DOI":"10.1074\/jbc.272.41.25968","article-title":"Gp60 activation mediates albumin transcytosis in endothelial cells by tyrosine kinase-dependent pathway","volume":"272","author":"Tiruppathi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1083\/jcb.150.5.1057","article-title":"Endothelial cell-surface gp60 activates vesicle formation and trafficking via Gi-coupled Src kinase signaling pathway","volume":"150","author":"Minshall","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1091\/mbc.E15-11-0756","article-title":"Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae","volume":"27","author":"Zimnicka","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/CIRCRESAHA.109.201673","article-title":"Phosphorylation of caveolin-1 regulates oxidant-induced pulmonary vascular permeability via paracellular and transcellular pathways","volume":"105","author":"Sun","year":"2009","journal-title":"Circ. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00000542-200604000-00023","article-title":"Isoflurane, but not sevoflurane, increases transendothelial albumin permeability in the isolated rat lung: Role for enhanced phosphorylation of caveolin-1","volume":"104","author":"Hu","year":"2006","journal-title":"Anesthesiology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/cvr\/cvr279","article-title":"Atrial natriuretic peptide enhances microvascular albumin permeability by the caveolae-mediated transcellular pathway","volume":"93","author":"Chen","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"L720","DOI":"10.1152\/ajplung.00157.2015","article-title":"Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase","volume":"310","author":"Kuebler","year":"2016","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"32180","DOI":"10.1038\/srep32180","article-title":"High mobility group box protein 1 boosts endothelial albumin transcytosis through the RAGE\/Src\/caveolin-1 pathway","volume":"6","author":"Shang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"31855","DOI":"10.1038\/srep31855","article-title":"Caveolae-mediated albumin transcytosis is enhanced in dengue-infected human endothelial cells: A model of vascular leakage in dengue hemorrhagic fever","volume":"6","author":"Chanthick","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_84","first-page":"194","article-title":"Electron microscopic study of the vascular endothelial cell in dengue hemorrhagic fever","volume":"11","author":"Sahaphong","year":"1980","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4269\/ajtmh.2007.77.151","article-title":"Acute respiratory failure in adult patients with dengue virus infection","volume":"77","author":"Wang","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_86","first-page":"55","article-title":"Composition of pleural fluid in dengue hemorrhagic fever","volume":"62","author":"Chavalittamrong","year":"1979","journal-title":"J. Med. Assoc. Thail."},{"key":"ref_87","first-page":"1211","article-title":"Diagnostic approach to pleural effusion in adults","volume":"73","author":"Porcel","year":"2006","journal-title":"Am. Fam. Phys."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1183\/09031936.97.10030714","article-title":"Transudative effusions","volume":"10","author":"Kinasewitz","year":"1997","journal-title":"Eur. Respir. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1590\/S1807-59322009000900010","article-title":"Does the evaluation of coagulation factors contribute to etiological diagnosis of pleural effusions?","volume":"64","author":"Vaz","year":"2009","journal-title":"Clinics"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1440-1843.2004.00633.x","article-title":"Pathogenesis of pleural fibrosis","volume":"9","author":"Mutsaers","year":"2004","journal-title":"Respirology"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/10\/2\/69\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:54:13Z","timestamp":1760194453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/10\/2\/69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":90,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2]]}},"alternative-id":["v10020069"],"URL":"https:\/\/doi.org\/10.3390\/v10020069","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,8]]}}}