{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:05:36Z","timestamp":1788350736099,"version":"build-2803163510"},"reference-count":63,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T00:00:00Z","timestamp":1526083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","award":["FRCALL12-6-2-0009"],"award-info":[{"award-number":["FRCALL12-6-2-0009"]}],"id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Annotated whole genome sequences of three isolates of the Akhmeta virus (AKMV), a novel species of orthopoxvirus (OPXV), isolated from the Akhmeta and Vani regions of the country Georgia, are presented and discussed. The AKMV genome is similar in genomic content and structure to that of the cowpox virus (CPXV), but a lower sequence identity was found between AKMV and Old World OPXVs than between other known species of Old World OPXVs. Phylogenetic analysis showed that AKMV diverged prior to other Old World OPXV. AKMV isolates formed a monophyletic clade in the OPXV phylogeny, yet the sequence variability between AKMV isolates was higher than between the monkeypox virus strains in the Congo basin and West Africa. An AKMV isolate from Vani contained approximately six kb sequence in the left terminal region that shared a higher similarity with CPXV than with other AKMV isolates, whereas the rest of the genome was most similar to AKMV, suggesting recombination between AKMV and CPXV in a region containing several host range and virulence genes.<\/jats:p>","DOI":"10.3390\/v10050252","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T02:57:20Z","timestamp":1526266640000},"page":"252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Genome Sequences of Akhmeta Virus, an Early Divergent Old World Orthopoxvirus"],"prefix":"10.3390","volume":"10","author":[{"given":"Jinxin","family":"Gao","sequence":"first","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-7156","authenticated-orcid":false,"given":"Crystal","family":"Gigante","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterine","family":"Khmaladze","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Epidemiology, National Center for Disease Control and Public Health of Georgia, 9 M. Asatiani Street, Tbilisi 0177, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyuyun","family":"Tang","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitni","family":"Davidson","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgi","family":"Maghlakelidze","sequence":"additional","affiliation":[{"name":"Division of Global Health Protection (DGHP), Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Geleishvili","sequence":"additional","affiliation":[{"name":"Division of Global Health Protection (DGHP), Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maka","family":"Kokhreidze","sequence":"additional","affiliation":[{"name":"Laboratory of the Ministry of Agriculture of Georgia (LMA), Animal Disease Diagnostic Department, 49 Vaso Godziashvilis Street, Tbilisi 0159, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin S.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginny","family":"Emerson","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,12]]},"reference":[{"key":"ref_1","first-page":"2943","article-title":"Poxviruses","volume":"2","author":"Damon","year":"2007","journal-title":"Fileds Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.it.2004.10.002","article-title":"25 years since the eradication of smallpox: Why poxvirus research is still relevant","volume":"25","author":"Mahalingam","year":"2004","journal-title":"Trends Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Dabrowski, P.W., Radonic, A., Kurth, A., and Nitsche, A. 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