{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T01:35:21Z","timestamp":1782437721957,"version":"3.54.5"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T00:00:00Z","timestamp":1530921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI127771, R21AI113128"],"award-info":[{"award-number":["R01AI127771, R21AI113128"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Tick-borne viral diseases continue to emerge in the United States, as clearly evident from the increase in Powassan encephalitis virus, Heartland virus, and Bourbon virus infections. Tick-borne flaviviruses (TBFVs) are transmitted to the mammalian host along with the infected tick saliva during blood-feeding. Successful tick feeding is facilitated by a complex repertoire of pharmacologically active salivary proteins\/factors in tick saliva. These salivary factors create an immunologically privileged micro-environment in the host\u2019s skin that influences virus transmission and pathogenesis. In this review, we will highlight tick determinants of TBFV transmission with a special emphasis on tick\u2013virus\u2013host interactions at the cutaneous interface.<\/jats:p>","DOI":"10.3390\/v10070362","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T11:18:53Z","timestamp":1531135133000},"page":"362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Tick\u2013Virus\u2013Host Interactions at the Cutaneous Interface: The Nidus of Flavivirus Transmission"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0494-9670","authenticated-orcid":false,"given":"Meghan E.","family":"Hermance","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch (UTMB), 301 University Boulevard, Galveston, TX 77555-0609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravanan","family":"Thangamani","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch (UTMB), 301 University Boulevard, Galveston, TX 77555-0609, USA"},{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch (UTMB), Galveston, TX 77555-0609, USA"},{"name":"Center for Tropical Diseases, University of Texas Medical Branch (UTMB), Galveston, TX 77555-0609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat. 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