{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:03:05Z","timestamp":1760241785061,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 A15436","HHSN266200400036C"],"award-info":[{"award-number":["U01 A15436","HHSN266200400036C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Taterapox virus (TATV) is phylogenetically the closest related virus to variola\u2014the etiological agent of smallpox. Despite the similarity, few studies have evaluated the virus. In vivo, TATV can infect several animals but produces an inapparent infection in wild-type mice; however, TATV does cause morbidity and mortality in some immunocompromised strains. We employed in vitro techniques to compare TATV to ectromelia (ECTV) and vaccinia (VACV) viruses. Both ECTV and TATV replicate efficiently in primate cell lines but TATV replicates poorly in murine cells lines. Furthermore, TATV induces cytopathic effects, but to a lesser extent than ECTV, and changes cytoskeletal networks differently than both ECTV and VACV. Bioinformatic studies revealed differences in several immunomodulator open reading frames that could contribute to the reduced virulence of TATV, which were supported by in vitro cytokine assays.<\/jats:p>","DOI":"10.3390\/v10090463","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T02:49:34Z","timestamp":1535597374000},"page":"463","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Virology of Taterapox Virus In Vitro"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1079-0988","authenticated-orcid":false,"given":"Scott","family":"Parker","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Camilo de Oliveira","sequence":"additional","affiliation":[{"name":"Grupo de Transdu\u00e7\u00e3o de Sinal do Laborat\u00f3rio de V\u00edrus, Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais, Avenida Ant\u00f4nio Carlos 6627, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot J.","family":"Lefkowitz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, BBRB 276\/11, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Curtis","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, BBRB 276\/11, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udio A.","family":"Bonjardim","sequence":"additional","affiliation":[{"name":"Grupo de Transdu\u00e7\u00e3o de Sinal do Laborat\u00f3rio de V\u00edrus, Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais, Avenida Ant\u00f4nio Carlos 6627, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S. M.","family":"Wold","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hollyce","family":"Hartzler","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Crump","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Mark","family":"Buller","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.virol.2010.10.021","article-title":"Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: Pathogenesis, prophylaxis, and antiviral therapy","volume":"409","author":"Chen","year":"2011","journal-title":"Virology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0042-6822(85)90111-4","article-title":"Orthopoxvirus DNA: A comparison of restriction profiles and maps","volume":"143","author":"Esposito","year":"1985","journal-title":"Virology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.1125134","article-title":"Genome sequence diversity and clues to the evolution of variola (smallpox) virus","volume":"313","author":"Esposito","year":"2006","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/infdis\/132.6.677","article-title":"Isolation of poxvirus from an African Rodent","volume":"132","author":"Lourie","year":"1975","journal-title":"J. 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