{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T09:28:32Z","timestamp":1780824512407,"version":"3.54.1"},"reference-count":72,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005900","name":"Minist\u00e8re de la D\u00e9fense","doi-asserted-by":"publisher","award":["PDH-2-NRBC-4-B2-408"],"award-info":[{"award-number":["PDH-2-NRBC-4-B2-408"]}],"id":[{"id":"10.13039\/501100005900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011658","name":"French Infrastructure for Integrated Structural Biology","doi-asserted-by":"publisher","award":["ANR-10-INSB-05-02"],"award-info":[{"award-number":["ANR-10-INSB-05-02"]}],"id":[{"id":"10.13039\/501100011658","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GRAL","award":["ANR-10-LABX-49-01"],"award-info":[{"award-number":["ANR-10-LABX-49-01"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-14-EBOL-0002-01"],"award-info":[{"award-number":["ANR-14-EBOL-0002-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Since the largest 2014\u20132016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral innate immune defense. A screening of Ebola glycoprotein (GP)-collectins interactions revealed the specific interaction of human surfactant protein D (hSP-D), a lectin expressed in lung and liver, two compartments where Ebola was found in vivo. Further analyses have demonstrated an involvement of hSP-D in the enhancement of virus infection in several in vitro models. Similar effects were observed for porcine SP-D (pSP-D). In addition, both hSP-D and pSP-D interacted with Reston virus (RESTV) GP and enhanced pseudoviral infection in pulmonary cells. Thus, our study reveals a novel partner of Ebola GP that may participate to enhance viral spread.<\/jats:p>","DOI":"10.3390\/v11010015","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T11:31:21Z","timestamp":1545823881000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction"],"prefix":"10.3390","volume":"11","author":[{"given":"Anne-Laure","family":"Favier","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Virologie, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Unit\u00e9 Imagerie; Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-355X","authenticated-orcid":false,"given":"Olivier","family":"Reynard","sequence":"additional","affiliation":[{"name":"Molecular basis of viral pathogenicity, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111\u2014CNRS UMR5308, Universit\u00e9 Lyon 1, ENS de Lyon, 69365 LYON CEDEX 07, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Gout","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"van Eijk","sequence":"additional","affiliation":[{"name":"Division of Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3512 Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-5201","authenticated-orcid":false,"given":"Henk P.","family":"Haagsman","sequence":"additional","affiliation":[{"name":"Division of Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3512 Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Crouch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Volchkov","sequence":"additional","affiliation":[{"name":"Molecular basis of viral pathogenicity, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111\u2014CNRS UMR5308, Universit\u00e9 Lyon 1, ENS de Lyon, 69365 LYON CEDEX 07, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Peyrefitte","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Virologie, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-0302","authenticated-orcid":false,"given":"Nicole M.","family":"Thielens","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,26]]},"reference":[{"key":"ref_1","first-page":"e00137","article-title":"Transmission of Ebola viruses: What we know and what we do not know","volume":"6","author":"Osterholm","year":"2015","journal-title":"mBio"},{"key":"ref_2","first-page":"51","article-title":"Identifying the pattern of molecular evolution for Zaire ebolavirus in the 2014 outbreak in West Africa","volume":"32","author":"Liu","year":"2015","journal-title":"Infect. 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