{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:10:05Z","timestamp":1787616605229,"version":"build-2736575974"},"reference-count":130,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Natural Science Foundation of China , China Agricultural Research System, Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System , and Special Fund for the Key Laboratory of Animal Disease and Human Health","award":["31402220\uff0cCARS-42-17\uff0cCARS-SVDIP\uff0c2016JPT0004"],"award-info":[{"award-number":["31402220\uff0cCARS-42-17\uff0cCARS-SVDIP\uff0c2016JPT0004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Herpesvirus infection is an orderly, regulated process. Among these viruses, the encapsidation of viral DNA is a noteworthy link; the entire process requires a powered motor that binds to viral DNA and carries it into the preformed capsid. Studies have shown that this power motor is a complex composed of a large subunit, a small subunit, and a third subunit, which are collectively known as terminase. The terminase large subunit is highly conserved in herpesvirus. It mainly includes two domains: the C-terminal nuclease domain, which cuts the viral concatemeric DNA into a monomeric genome, and the N-terminal ATPase domain, which hydrolyzes ATP to provide energy for the genome cutting and transfer activities. Because this process is not present in eukaryotic cells, it provides a reliable theoretical basis for the development of safe and effective anti-herpesvirus drugs. This article reviews the genetic characteristics, protein structure, and function of the herpesvirus terminase large subunit, as well as the antiviral drugs that target the terminase large subunit. We hope to provide a theoretical basis for the prevention and treatment of herpesvirus.<\/jats:p>","DOI":"10.3390\/v11030219","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T03:01:23Z","timestamp":1551754883000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Terminase Large Subunit Provides a New Drug Target for Herpesvirus Treatment"],"prefix":"10.3390","volume":"11","author":[{"given":"Linlin","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyong","family":"Jia","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-1037","authenticated-orcid":false,"given":"Shun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Key Laboratory of 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Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaqiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunya","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan 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611130, Sichuan, China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"ref_1","first-page":"2505","article-title":"Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018)","volume":"162","author":"King","year":"2018","journal-title":"Arch. 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