{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:05:48Z","timestamp":1789142748906,"version":"build-2803163510"},"reference-count":62,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Since the eradication of smallpox, there have been increases in poxvirus infections and the emergence of several novel poxviruses that can infect humans and domestic animals. In 2015, a novel poxvirus was isolated from a resident of Alaska. Diagnostic testing and limited sequence analysis suggested this isolate was a member of the Orthopoxvirus (OPXV) genus but was highly diverged from currently known species, including Akhmeta virus. Here, we present the complete 210,797 bp genome sequence of the Alaska poxvirus isolate, containing 206 predicted open reading frames. Phylogenetic analysis of the conserved central region of the genome suggested the Alaska isolate shares a common ancestor with Old World OPXVs and is diverged from New World OPXVs. We propose this isolate as a member of a new OPXV species, Alaskapox virus (AKPV). The AKPV genome contained host range and virulence genes typical of OPXVs but lacked homologs of C4L and B7R, and the hemagglutinin gene contained a unique 120 amino acid insertion. Seven predicted AKPV proteins were most similar to proteins in non-OPXV Murmansk or NY_014 poxviruses. Genomic analysis revealed evidence suggestive of recombination with Ectromelia virus in two putative regions that contain seven predicted coding sequences, including the A-type inclusion protein.<\/jats:p>","DOI":"10.3390\/v11080708","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T11:39:37Z","timestamp":1564659577000},"page":"708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Genome of Alaskapox Virus, a Novel Orthopoxvirus Isolated from Alaska"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-7156","authenticated-orcid":false,"given":"Crystal M.","family":"Gigante","sequence":"first","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Gao","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyuyun","family":"Tang","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"McCollum","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary G.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitni","family":"Davidson","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Alaska Division of Public Health, Section of Epidemiology, Anchorage, AK 99503, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7729-7680","authenticated-orcid":false,"given":"Victoria A.","family":"Olson","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.meegid.2013.10.014","article-title":"Poxviruses and the evolution of host range and virulence","volume":"21","author":"Haller","year":"2014","journal-title":"Infect. Genet. Evol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.coviro.2017.11.012","article-title":"Understanding orthopoxvirus host range and evolution: From the enigmatic to the usual suspects","volume":"28","author":"Reynolds","year":"2018","journal-title":"Curr. Opin. Virol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.vetmic.2009.08.026","article-title":"Zoonotic poxviruses","volume":"140","author":"Essbauer","year":"2010","journal-title":"Vet. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/QCO.0b013e3282f44c74","article-title":"Cowpox virus infection: An emerging health threat","volume":"21","author":"Vorou","year":"2008","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_5","first-page":"pii=3178","article-title":"Sporadic human cases of cowpox in Germany","volume":"12","author":"Nitsche","year":"2007","journal-title":"Eurosurveillance"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1473-3099(03)00856-9","article-title":"Human monkeypox: An emerging zoonosis","volume":"4","author":"Eckburg","year":"2004","journal-title":"Lancet Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16262","DOI":"10.1073\/pnas.1005769107","article-title":"Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo","volume":"107","author":"Rimoin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4269\/ajtmh.15-0168","article-title":"Introduction of Monkeypox into a Community and Household: Risk Factors and Zoonotic Reservoirs in the Democratic Republic of the Congo","volume":"93","author":"Nolen","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.medmal.2018.02.010","article-title":"Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic","volume":"48","author":"Kalthan","year":"2018","journal-title":"Med. Mal. Infect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.cmi.2016.07.004","article-title":"Emerging diseases-the monkeypox epidemic in the Democratic Republic of the Congo","volume":"22","author":"Kantele","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_11","unstructured":"Centers for Disease Control and Prevention (2003). Multistate outbreak of monkeypox\u2014Illinois, Indiana, and Wisconsin, 2003. Morb. Mortal. Wkly. Rep., 52, 537\u2013540."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1590\/S0036-46652004000600004","article-title":"Human vaccinia-like virus outbreaks in Sao Paulo and Goias States, Brazil: Virus detection, isolation and identification","volume":"46","author":"Kisielius","year":"2004","journal-title":"Rev. Inst. Med. Trop Sao Paulo"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1006\/viro.2000.0603","article-title":"An emergent poxvirus from humans and cattle in Rio de Janeiro State: Cantagalo virus may derive from Brazilian smallpox vaccine","volume":"277","author":"Damaso","year":"2000","journal-title":"Virology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3201\/eid2104.140351","article-title":"Outbreak of severe zoonotic vaccinia virus infection, Southeastern Brazil","volume":"21","author":"Abrahao","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.3201\/eid1112.050773","article-title":"Passatempo virus, a vaccinia virus strain, Brazil","volume":"11","author":"Leite","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3201\/eid2505.190076","article-title":"Diagnosis of Imported Monkeypox, Israel, 2018","volume":"25","author":"Erez","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Vaughan, A., Aarons, E., Astbury, J., Balasegaram, S., Beadsworth, M., Beck, C.R., Chand, M., O\u2019Connor, C., Dunning, J., and Ghebrehewet, S. (2018). Two cases of monkeypox imported to the United Kingdom, September 2018. Eurosurveillance, 23.","DOI":"10.2807\/1560-7917.ES.2018.23.38.1800509"},{"key":"ref_18","unstructured":"(2019, July 15). Singapore Ministry of Health, Confirmed Imported Case of Monkeypox in Singapore. Singapore Government: 9 May 2019, Available online: https:\/\/www.moh.gov.sg\/news-highlights\/details\/confirmed-imported-case-of-monkeypox-in-singapore."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0140-6736(11)60694-6","article-title":"The remaining smallpox stocks: The healthiest outcome","volume":"379","author":"Mombouli","year":"2012","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"916","DOI":"10.5694\/j.1326-5377.1980.tb135034.x","article-title":"The global eradication of smallpox","volume":"1","author":"Fenner","year":"1980","journal-title":"Med. J. Aust."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tim.2011.12.001","article-title":"Outbreaks of human monkeypox after cessation of smallpox vaccination","volume":"20","author":"Reynolds","year":"2012","journal-title":"Trends Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMoa1407647","article-title":"Human infection with a zoonotic orthopoxvirus in the country of Georgia","volume":"372","author":"Vora","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/cid\/civ643","article-title":"Novel Poxvirus Infection in an Immune Suppressed Patient","volume":"61","author":"Lakis","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s11262-017-1501-8","article-title":"Two novel poxviruses with unusual genome rearrangements: NY_014 and Murmansk","volume":"53","author":"Smithson","year":"2017","journal-title":"Virus Genes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"10959","DOI":"10.1128\/JVI.01195-15","article-title":"Out of the Reservoir: Phenotypic and Genotypic Characterization of a Novel Cowpox Virus Isolated from a Common Vole","volume":"89","author":"Hoffmann","year":"2015","journal-title":"J. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/cid\/ciu790","article-title":"Novel poxvirus infection in 2 patients from the United States","volume":"60","author":"Osadebe","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Gao, J., Gigante, C., Khmaladze, E., Liu, P., Tang, S., Wilkins, K., Zhao, K., Davidson, W., Nakazawa, Y., and Maghlakelidze, G. (2018). Genome Sequences of Akhmeta Virus, an Early Divergent Old World Orthopoxvirus. Viruses, 10.","DOI":"10.3390\/v10050252"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.3201\/eid2312.162098","article-title":"Fatal Outbreak in Tonkean Macaques Caused by Possibly Novel Orthopoxvirus, Italy, January 2015","volume":"23","author":"Cardeti","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Gruber, C.E.M., Giombini, E., Selleri, M., Tausch, S.H., Andrusch, A., Tyshaieva, A., Cardeti, G., Lorenzetti, R., De Marco, L., and Carletti, F. (2018). Whole Genome Characterization of Orthopoxvirus (OPV) Abatino, a Zoonotic Virus Representing a Putative Novel Clade of Old World Orthopoxviruses. Viruses, 10.","DOI":"10.3390\/v10100546"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/cid\/cix219","article-title":"Novel Orthopoxvirus Infection in an Alaska Resident","volume":"64","author":"Springer","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.3201\/eid2409.171283","article-title":"Novel Orthopoxvirus and Lethal Disease in Cat, Italy","volume":"24","author":"Lanave","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_32","unstructured":"Skinner, M.A., Buller, R.M., Damon, I.K., Lefkowitz, E.J., McFadden, G., McInnes, C.J., Mercer, A.A., Moyer, R.W., and Upton, C. (2019, May 15). Poxviridae. Available online: https:\/\/talk.ictvonline.org\/ictv-reports\/ictv_9th_report\/dsdna-viruses-2011\/w\/dsdna_viruses\/74\/poxviridae."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mauldin, M.R., Antwerpen, M., Emerson, G.L., Li, Y., Zoeller, G., Carroll, D.S., and Meyer, H. (2017). Cowpox Virus: What\u2019s in a Name?. Viruses, 9.","DOI":"10.3390\/v9050101"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Carroll, D.S., Emerson, G.L., Li, Y., Sammons, S., Olson, V., Frace, M., Nakazawa, Y., Czerny, C.P., Tryland, M., and Kolodziejek, J. (2011). Chasing Jenner\u2019s vaccine: Revisiting cowpox virus classification. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023086"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11262-016-1388-9","article-title":"The genomes of three North American orthopoxviruses","volume":"53","author":"Smithson","year":"2017","journal-title":"Virus Genes"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1093\/nar\/gkq275","article-title":"Ab initio gene identification in metagenomic sequences","volume":"38","author":"Zhu","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1093\/nar\/29.12.2607","article-title":"GeneMarkS: A self-training method for prediction of gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regions","volume":"29","author":"Besemer","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1093\/nar\/gkf436","article-title":"MAFFT: A novel method for rapid multiple sequence alignment based on fast Fourier transform","volume":"30","author":"Katoh","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: Improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Wickham, H. (2016). ggplot2: Elegant Graphics for Data Analysis, Springer Nature.","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Bouckaert, R., Heled, J., Kuhnert, D., Vaughan, T., Wu, C.H., Xie, D., Suchard, M.A., Rambaut, A., and Drummond, A.J. (2014). BEAST 2: A software platform for Bayesian evolutionary analysis. PLoS Comput. Biol., 10.","DOI":"10.1371\/journal.pcbi.1003537"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/molbev\/msm088","article-title":"PAML 4: Phylogenetic analysis by maximum likelihood","volume":"24","author":"Yang","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/molbev\/msi097","article-title":"Bayes empirical bayes inference of amino acid sites under positive selection","volume":"22","author":"Yang","year":"2005","journal-title":"Mol. Biol. Evol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2307\/2408542","article-title":"Distance Methods for Inferring Phylogenies: A Justification","volume":"38","author":"Felsenstein","year":"1984","journal-title":"Evolution"},{"key":"ref_46","unstructured":"Wickham, H., and Henry, L. (2019, April 25). Tidyr: Easily Tidy Data with \u2018Spread()\u2019 and \u2018Gather()\u2019 Functions; R Package Version 0.8.0. Available online: https:\/\/CRAN.R-project.org\/package=tidyr."},{"key":"ref_47","unstructured":"R Core Team (2017). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing."},{"key":"ref_48","unstructured":"RStudio Team (2016). RStudio: Integrated Development for R, RStudio, Inc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1099\/vir.0.19565-0","article-title":"Poxvirus genomes: A phylogenetic analysis","volume":"85","author":"Gubser","year":"2004","journal-title":"J. Gen. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1099\/vir.0.000202","article-title":"Genome sequence and comparative virulence of raccoonpox virus: The first North American poxvirus sequence","volume":"96","author":"Fleischauer","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.1128\/JVI.77.13.7590-7600.2003","article-title":"Poxvirus orthologous clusters: Toward defining the minimum essential poxvirus genome","volume":"77","author":"Upton","year":"2003","journal-title":"J. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.virusres.2006.01.016","article-title":"Poxviruses: Past, present and future","volume":"117","author":"Lefkowitz","year":"2006","journal-title":"Virus Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11262-010-0560-x","article-title":"Characterization of indels in poxvirus genomes","volume":"42","author":"Coulson","year":"2011","journal-title":"Virus Genes"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.1125134","article-title":"Genome sequence diversity and clues to the evolution of variola (smallpox) virus","volume":"313","author":"Esposito","year":"2006","journal-title":"Science"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"15655","DOI":"10.1073\/pnas.2136653100","article-title":"Extensive gene gain associated with adaptive evolution of poxviruses","volume":"100","author":"McLysaght","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"10230","DOI":"10.1128\/JVI.00637-11","article-title":"The genome of Yoka poxvirus","volume":"85","author":"Zhao","year":"2011","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/viro.1999.0116","article-title":"Vaccinia virus gene B7R encodes an 18-kDa protein that is resident in the endoplasmic reticulum and affects virus virulence","volume":"267","author":"Price","year":"2000","journal-title":"Virology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.meegid.2012.12.002","article-title":"A survey of host range genes in poxvirus genomes","volume":"14","author":"Bratke","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ympev.2004.12.008","article-title":"Poxvirus genome evolution by gene gain and loss","volume":"35","author":"Hughes","year":"2005","journal-title":"Mol. Phylogenet. Evol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Jarahian, M., Fiedler, M., Cohnen, A., Djandji, D., Hammerling, G.J., Gati, C., Cerwenka, A., Turner, P.C., Moyer, R.W., and Watzl, C. (2011). Modulation of NKp30- and NKp46-mediated natural killer cell responses by poxviral hemagglutinin. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002195"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/mr.55.1.80-122.1991","article-title":"Poxvirus pathogenesis","volume":"55","author":"Buller","year":"1991","journal-title":"Microbiol. Rev."},{"key":"ref_62","first-page":"553","article-title":"Mousepox (infectious ectromelia): Past, present, and future","volume":"31","author":"Fenner","year":"1981","journal-title":"Lab. Anim. Sci."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/11\/8\/708\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:12:29Z","timestamp":1760188349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/11\/8\/708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,1]]},"references-count":62,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8]]}},"alternative-id":["v11080708"],"URL":"https:\/\/doi.org\/10.3390\/v11080708","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,1]]}}}