{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:24:44Z","timestamp":1792524284711,"version":"4.5.0"},"reference-count":188,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Feline infectious peritonitis (FIP) is a fatal disease that poses several challenges for veterinarians: clinical signs and laboratory changes are non-specific, and there are two pathotypes of the etiologic agent feline coronavirus (FCoV), sometimes referred to as feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV) that vary fundamentally in their virulence, but are indistinguishable by a number of diagnostic methods. This review focuses on all important steps every veterinary practitioner has to deal with and new diagnostic tests that can be considered when encountering a cat with suspected FIP with the aim to establish a definitive diagnosis. It gives an overview on all available direct and indirect diagnostic tests and their sensitivity and specificity reported in the literature in different sample material. By providing summarized data for sensitivity and specificity of each diagnostic test and each sample material, which can easily be accessed in tables, this review can help to facilitate the interpretation of different diagnostic tests and raise awareness of their advantages and limitations. Additionally, diagnostic trees depict recommended diagnostic steps that should be performed in cats suspected of having FIP based on their clinical signs or clinicopathologic abnormalities. These steps can easily be followed in clinical practice.<\/jats:p>","DOI":"10.3390\/v11111068","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:24:32Z","timestamp":1573817072000},"page":"1068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Diagnosis of Feline Infectious Peritonitis: A Review of the Current Literature"],"prefix":"10.3390","volume":"11","author":[{"given":"Sandra","family":"Felten","sequence":"first","affiliation":[{"name":"Clinic of Small Animal Medicine, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet Munich, Veterinaerstr. 13, 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet Munich, Veterinaerstr. 13, 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jfms.2008.02.006","article-title":"Pathogenesis of feline enteric coronavirus infection","volume":"10","author":"Pedersen","year":"2008","journal-title":"J. Feline Med. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jfms.2003.08.008","article-title":"Common virus infections in cats, before and after being placed in shelters, with emphasis on feline enteric coronavirus","volume":"6","author":"Pedersen","year":"2004","journal-title":"J. Feline Med. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1051\/vetres\/2010043","article-title":"Pathogenic characteristics of persistent feline enteric coronavirus infection in cats","volume":"41","author":"Vogel","year":"2010","journal-title":"Vet. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1006\/viro.1998.9045","article-title":"Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses","volume":"243","author":"Vennema","year":"1998","journal-title":"Virology"},{"key":"ref_5","first-page":"363","article-title":"Infection studies in kittens, using feline infectious peritonitis virus propagated in cell culture","volume":"42","author":"Pedersen","year":"1981","journal-title":"Am. J. Vet. Res."},{"key":"ref_6","first-page":"368","article-title":"An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis","volume":"42","author":"Pedersen","year":"1981","journal-title":"Am. J. Vet. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/1098612X15586209","article-title":"Clinical and laboratory features of cats with feline infectious peritonitis-a retrospective study of 231 confirmed cases (2000\u20132010)","volume":"18","author":"Riemer","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfms.2005.04.003","article-title":"Prevalence of feline infectious peritonitis in specific cat breeds","volume":"8","author":"Radzai","year":"2006","journal-title":"J. Feline Med. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2460\/javma.2001.218.1111","article-title":"Epidemiology of feline infectious peritonitis among cats examined at veterinary medical teaching hospitals","volume":"218","author":"Rohrbach","year":"2001","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_10","first-page":"14","article-title":"The inheritance of susceptibility to feline infectious peritonitis in purebred catteries","volume":"24","author":"Foley","year":"1996","journal-title":"Feline Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1748-5827.2011.01042.x","article-title":"Performances of different diagnostic tests for feline infectious peritonitis in challenging clinical cases","volume":"52","author":"Giori","year":"2011","journal-title":"J. Small Anim. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jfms.2008.09.008","article-title":"A review of feline infectious peritonitis virus infection: 1963\u20132008","volume":"11","author":"Pedersen","year":"2009","journal-title":"J. Feline Med. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/0300985814522077","article-title":"Feline infectious peritonitis: Still an enigma?","volume":"51","author":"Kipar","year":"2014","journal-title":"Vet. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jfms.2004.07.001","article-title":"Inflammatory cerebrospinal fluid analysis in cats: Clinical diagnosis and outcome","volume":"7","author":"Singh","year":"2005","journal-title":"J. Feline Med. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/1040638718756460","article-title":"Comparison of the performance of laboratory tests in the diagnosis of feline infectious peritonitis","volume":"30","author":"Stranieri","year":"2018","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1939-1676.2003.tb02515.x","article-title":"Comparison of different tests to diagnose feline infectious peritonitis","volume":"17","author":"Hartmann","year":"2003","journal-title":"J. Vet. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1439-0442.2002.00494.x","article-title":"Laboratory changes consistent with feline infectious peritonitis in cats from multicat environments","volume":"49","author":"Paltrinieri","year":"2002","journal-title":"J. Vet. Med. A. Physiol. Pathol. Clin. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1053\/jfms.2001.0126","article-title":"Laboratory profiles in cats with different pathological and immunohistochemical findings due to feline infectious peritonitis (fip)","volume":"3","author":"Paltrinieri","year":"2001","journal-title":"J. Feline Med. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/vr.129.10.209","article-title":"Feline infectious peritonitis: A review of clinicopathological changes in 65 cases, and a critical assessment of their diagnostic value","volume":"129","author":"Sparkes","year":"1991","journal-title":"Vet. Rec."},{"key":"ref_20","first-page":"345","article-title":"An appraisal of the value of laboratory tests in the diagnosis of feline infectious peritonitis","volume":"30","author":"Sparkes","year":"1994","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1751-0813.2005.tb13044.x","article-title":"Clinicopathological findings associated with feline infectious peritonitis in sydney, australia: 42 cases (1990\u20132002)","volume":"83","author":"Norris","year":"2005","journal-title":"Aust. Vet. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jfms.2010.09.014","article-title":"Clinicopathological findings and disease staging of feline infectious peritonitis: 51 cases from 2003 to 2009 in taiwan","volume":"13","author":"Tsai","year":"2011","journal-title":"J. Feline Med. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1177\/1098612X12454862","article-title":"Positive predictive value of albumin: Globulin ratio for feline infectious peritonitis in a mid-western referral hospital population","volume":"14","author":"Jeffery","year":"2012","journal-title":"J. Feline Med. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jfms.2010.03.018","article-title":"Serum protein electrophoresis in 155 cats","volume":"12","author":"Taylor","year":"2010","journal-title":"J. Feline Med. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/vr.141.12.299","article-title":"Value of alpha 1-acid glycoprotein in the diagnosis of feline infectious peritonitis","volume":"141","author":"Duthie","year":"1997","journal-title":"Vet. Rec."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S1090-0233(03)00055-8","article-title":"Changes in some acute phase protein and immunoglobulin concentrations in cats affected by feline infectious peritonitis or exposed to feline coronavirus infection","volume":"167","author":"Giordano","year":"2004","journal-title":"Vet. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1177\/1098612X16658925","article-title":"Usefulness of acute phase proteins in differentiating between feline infectious peritonitis and other diseases in cats with body cavity effusions","volume":"19","author":"Hazuchova","year":"2017","journal-title":"J. Feline Med. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/104063870701900306","article-title":"Critical assessment of the diagnostic value of feline alpha1-acid glycoprotein for feline infectious peritonitis using the likelihood ratios approach","volume":"19","author":"Paltrinieri","year":"2007","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_29","first-page":"503","article-title":"Serum alhpa 1-acid glycoprotein concentrations in healthy and tumor-bearing cats","volume":"14","author":"Selting","year":"2000","journal-title":"J. Vet. Intern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1939-165X.2005.tb00019.x","article-title":"Acute phase proteins in dogs and cats: Current knowledge and future perspectives","volume":"34","author":"Ceron","year":"2005","journal-title":"Vet. Clin. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jfms.2007.01.002","article-title":"Serum alpha1-acid glycoprotein (agp) concentration in non-symptomatic cats with feline coronavirus (fcov) infection","volume":"9","author":"Paltrinieri","year":"2007","journal-title":"J. Feline Med. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1751-0813.2012.00948.x","article-title":"Flow cytometric detection of alpha-1-acid glycoprotein on feline circulating leucocytes","volume":"90","author":"Paltrinieri","year":"2012","journal-title":"Aust. Vet. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1024\/0036-7281\/a000289","article-title":"Pericardial effusion in a cat with feline infectious peritonitis","volume":"154","author":"Fischer","year":"2012","journal-title":"Schweizer Archiv Tierheilkunde"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tvjl.2014.04.016","article-title":"An update on feline infectious peritonitis: Diagnostics and therapeutics","volume":"201","author":"Pedersen","year":"2014","journal-title":"Vet. J."},{"key":"ref_35","first-page":"192","article-title":"Cytology of body cavity effusions","volume":"23","author":"Hirschberger","year":"1995","journal-title":"Tier\u00e4rztliche Prax."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0034-5288(95)90007-1","article-title":"Validation of the determination of the activity of adenosine deaminase in the body effusions of cats","volume":"59","author":"Hirschberger","year":"1995","journal-title":"Res. Vet. Sci."},{"key":"ref_37","first-page":"431","article-title":"Clinical and chemical investigations of body cavity effusions","volume":"19","author":"Hirschberger","year":"1991","journal-title":"Tieraerztliche Prax."},{"key":"ref_38","first-page":"495","article-title":"Protein electrophoresis on effusions from cats as a diagnostic test for feline infectious peritonitis","volume":"24","author":"Shelly","year":"1988","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1939-165X.2012.00464.x","article-title":"Diagnostic accuracy of the rivalta test for feline infectious peritonitis","volume":"41","author":"Fischer","year":"2012","journal-title":"Vet. Clin. Pathol."},{"key":"ref_40","first-page":"3573","article-title":"Exudates, transudates and the rivalta reaction (1895). Current status and historical premises","volume":"70","author":"Vial","year":"1979","journal-title":"Minerva. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/vcp.12241","article-title":"High diagnostic accuracy of the sysmex xt-2000iv delta total nucleated cells on effusions for feline infectious peritonitis","volume":"44","author":"Giordano","year":"2015","journal-title":"Vet. Clin. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/1040638716689115","article-title":"Diagnosing feline infectious peritonitis using the sysmex xt-2000iv based on frozen supernatants from cavitary effusions","volume":"29","author":"Stranieri","year":"2017","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/jvim.14791","article-title":"Clinicopathologic features and magnetic resonance imaging findings in 24 cats with histopathologically confirmed neurologic feline infectious peritonitis","volume":"31","author":"Crawford","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1939-165X.2008.00028.x","article-title":"Use of albumin quotient and igg index to differentiate blood- vs brain-derived proteins in the cerebrospinal fluid of cats with feline infectious peritonitis","volume":"37","author":"Steinberg","year":"2008","journal-title":"Vet. Clin. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1939-1676.1998.tb02144.x","article-title":"Diagnostic features of clinical neurologic feline infectious peritonitis","volume":"12","author":"Foley","year":"1998","journal-title":"J. Vet. Intern. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2460\/javma.230.2.199","article-title":"Use of anti-coronavirus antibody testing of cerebrospinal fluid for diagnosis of feline infectious peritonitis involving the central nervous system in cats","volume":"230","author":"Boettcher","year":"2007","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1177\/0300985817728557","article-title":"Feline infectious peritonitis: Immunohistochemical features of ocular inflammation and the distribution of viral antigens in structures of the eye","volume":"54","author":"Ziolkowska","year":"2017","journal-title":"Vet. Pathol."},{"key":"ref_48","first-page":"417","article-title":"Ocular manifestations of feline infectious peritonitis","volume":"159","author":"Doherty","year":"1971","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2460\/javma.1991.198.01.135","article-title":"Histopathologic study of uveitis in cats: 139 cases (1978\u20131988)","volume":"198","author":"Peiffer","year":"1991","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/vop.12245","article-title":"Validity of aqueocentesis as a component of anterior uveitis investigation in dogs and cats","volume":"18","author":"Powell","year":"2015","journal-title":"Vet. Ophthalmol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/vop.12075","article-title":"Diagnostic utility of aqueocentesis and aqueous humor analysis in dogs and cats with anterior uveitis","volume":"17","author":"Wiggans","year":"2014","journal-title":"Vet. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1053\/jfms.2000.0090","article-title":"Feline infectious uveitis","volume":"2","author":"Lappin","year":"2000","journal-title":"J. Feline Med. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-1135(99)00101-7","article-title":"Histopathological alterations of lymphatic tissues in cats without feline infectious peritonitis after long-term exposure to fip virus","volume":"69","author":"Kipar","year":"1999","journal-title":"Vet. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jfms.2003.08.007","article-title":"High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (fcov) type i and in naturally fcov-infected cats","volume":"6","author":"Meli","year":"2004","journal-title":"J. Feline Med. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0165-2427(98)00156-1","article-title":"Antibody and cytokine responses in kittens during the development of feline infectious peritonitis (fip)","volume":"65","author":"Caney","year":"1998","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_56","first-page":"868","article-title":"Immunologic phenomena in the effusive form of feline infectious peritonitis","volume":"41","author":"Pedersen","year":"1980","journal-title":"Am. J. Vet. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vetmic.2014.10.025","article-title":"Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection","volume":"175","author":"Pedersen","year":"2015","journal-title":"Vet. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"20022","DOI":"10.1038\/srep20022","article-title":"Experimental feline enteric coronavirus infection reveals an aberrant infection pattern and shedding of mutants with impaired infectivity in enterocyte cultures","volume":"6","author":"Desmarets","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_59","first-page":"622","article-title":"Cats inoculated with feline infectious peritonitis virus exhibit a biphasic acute phase plasma protein response","volume":"123","author":"Stoddart","year":"1988","journal-title":"Vet. Rec."},{"key":"ref_60","first-page":"1449","article-title":"Serologic studies of naturally occurring feline infectious peritonitis","volume":"37","author":"Pedersen","year":"1976","journal-title":"Am. J. Vet. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/vr.131.9.202-a","article-title":"Feline coronavirus antibodies in cats","volume":"131","author":"Addie","year":"1992","journal-title":"Vet. Rec."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/1098612X14538873","article-title":"Utility of feline coronavirus antibody tests","volume":"17","author":"Addie","year":"2015","journal-title":"J. Feline Med. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1439-0450.1977.tb00976.x","article-title":"Seroepidemiology of feline infectious peritonitis virus infections using transmissible gastroenteritis virus as antigen","volume":"24","author":"Osterhaus","year":"1977","journal-title":"Zentralblatt f\u00fcr Veterin\u00e4rmedizin Reihe B"},{"key":"ref_64","first-page":"1487","article-title":"Feline infectious peritonitis: A worldwide serosurvey","volume":"40","author":"Horzinek","year":"1979","journal-title":"Am. J. Vet. Res."},{"key":"ref_65","first-page":"1209","article-title":"Feline coronavirus serotypes 1 and 2: Seroprevalence and association with disease in switzerland","volume":"12","author":"Kummrow","year":"2005","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jfms.2004.01.001","article-title":"Evaluation of an in-practice test for feline coronavirus antibodies","volume":"6","author":"Addie","year":"2004","journal-title":"J. Feline Med. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/104063870802000108","article-title":"Comparison of serologic techniques for the detection of antibodies against feline coronaviruses","volume":"20","author":"Pratelli","year":"2008","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_68","first-page":"46","article-title":"The history and interpretation of feline coronavirus serology","volume":"23","author":"Pedersen","year":"1995","journal-title":"Feline Pract."},{"key":"ref_69","first-page":"796","article-title":"Cats and coronaviruses","volume":"193","author":"Barlough","year":"1988","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/vr.146.15.419","article-title":"Long-term impact on a closed household of pet cats of natural infection with feline coronavirus, feline leukaemia virus and feline immunodeficiency virus","volume":"146","author":"Addie","year":"2000","journal-title":"Vet. Rec."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/vr.130.7.133","article-title":"A study of naturally occurring feline coronavirus infections in kittens","volume":"130","author":"Addie","year":"1992","journal-title":"Vet. Rec."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2460\/ajvr.1995.56.04.429","article-title":"Risk of feline infectious peritonitis in cats naturally infected with feline coronavirus","volume":"56","author":"Addie","year":"1995","journal-title":"Am. J. Vet. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/vr.131.2.35","article-title":"Coronavirus serology in healthy pedigree cats","volume":"131","author":"Sparkes","year":"1992","journal-title":"Vet. Rec."},{"key":"ref_74","first-page":"1164","article-title":"Fip antibody test-interpretation and recommendations","volume":"175","author":"Scott","year":"1979","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/0264-410X(90)90004-6","article-title":"Protection against feline infectious peritonitis by intranasal inoculation of a temperature-sensitive fipv vaccine","volume":"8","author":"Gerber","year":"1990","journal-title":"Vaccine"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4615-1899-0_36","article-title":"Protection of cats from infectious peritonitis by vaccination with a recombinant raccoon poxvirus expressing the nucleocapsid gene of feline infectious peritonitis virus","volume":"380","author":"Wasmoen","year":"1995","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1128\/JVI.78.8.3863-3871.2004","article-title":"Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis","volume":"78","author":"Haijema","year":"2004","journal-title":"J. Virol."},{"key":"ref_78","first-page":"92","article-title":"Clinical symptoms and diagnosis of feline infectious peritonitis","volume":"23","author":"Hirschberger","year":"1995","journal-title":"Tierarztliche Prax."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.2460\/ajvr.69.9.1179","article-title":"Evaluation of antibodies against feline coronavirus 7b protein for diagnosis of feline infectious peritonitis in cats","volume":"69","author":"Kennedy","year":"2008","journal-title":"Am. J. Vet. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/104063879801000119","article-title":"Correlation of genomic detection of feline coronavirus with various diagnostic assays for feline infectious peritonitis","volume":"10","author":"Kennedy","year":"1998","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/1098612X12467995","article-title":"Samples with high virus load cause a trend toward lower signal in feline coronavirus antibody tests","volume":"15","author":"Meli","year":"2013","journal-title":"J. Feline Med. Surg."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cvsm.2004.10.011","article-title":"Feline infectious peritonitis","volume":"35","author":"Hartmann","year":"2005","journal-title":"Vet. Clin. N. Am. Small. Anim. Pract."},{"key":"ref_83","unstructured":"Addie, D., and Jarrett, O. (1993, January 8\u201313). Isolation of Immune Complexes in Feline Infectious Peritonitis. Proceedings of the IXth International Congress of Virology Abstracts, Glasgow, UK."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jfms.2006.09.001","article-title":"Results of magnetic resonance imaging in 14 cats with meningoencephalitis","volume":"9","author":"Negrin","year":"2007","journal-title":"J. Feline Med. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/vr.148.21.649","article-title":"Use of a reverse-transcriptase polymerase chain reaction for monitoring the shedding of feline coronavirus by healthy cats","volume":"148","author":"Addie","year":"2001","journal-title":"Vet. Rec."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1099\/vir.0.19129-0","article-title":"Persistence and transmission of natural type i feline coronavirus infection","volume":"84","author":"Addie","year":"2003","journal-title":"J. Gen. Virol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1292\/jvms.66.89","article-title":"Detection of feline coronavirus antibody, feline immunodeficiency virus antibody, and feline leukemia virus antigen in ascites from cats with effusive feline infectious peritonitis","volume":"66","author":"Soma","year":"2004","journal-title":"J. Vet. Med. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jfms.2009.05.008","article-title":"Feline infectious peritonitis. Abcd guidelines on prevention and management","volume":"11","author":"Addie","year":"2009","journal-title":"J. Feline Med. Surg."},{"key":"ref_89","unstructured":"Lorusso, E., Mari, V., Losurdo, M., Lanave, G., Trotta, A., Dowgier, G., Colaianni, M.L., Zatelli, A., Elia, G., and Buonavoglia, D. (2017). Discrepancies between feline coronavirus antibody and nucleic acid detection in effusions of cats with suspected feline infectious peritonitis. Res. Vet. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1292\/jvms.17-0399","article-title":"Feline coronavirus antibody titer in cerebrospinal fluid from cats with neurological signs","volume":"80","author":"Soma","year":"2018","journal-title":"J. Vet. Med. Sci."},{"key":"ref_91","first-page":"2036","article-title":"Pathogenesis of feline infetious peritonitis: Pathologic changes and immunofluorescence","volume":"42","author":"Weiss","year":"1981","journal-title":"Am. J. Vet. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0147-9571(81)90003-5","article-title":"Antibody-mediated enhancement of disease in feline infectious peritonitis: Comparisons with dengue hemorrhagic fever","volume":"4","author":"Weiss","year":"1981","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0165-2427(98)00155-X","article-title":"Some aspects of humoral and cellular immunity in naturally occuring feline infectious peritonitis","volume":"65","author":"Paltrinieri","year":"1998","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.4049\/jimmunol.125.4.1606","article-title":"Isolation and characterization of feline c3 and evidence for the immune complex pathogenesis of feline infectious peritonitis","volume":"125","author":"Daha","year":"1980","journal-title":"J. Immunol."},{"key":"ref_95","first-page":"666","article-title":"Antibody, immune complexes, and complement activity fluctuations in kittens with experimentally induced feline infectious peritonitis","volume":"43","author":"Daha","year":"1982","journal-title":"Am. J. Vet. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01317889","article-title":"The virology and pathogenesis of feline infectious peritonitis. Brief review","volume":"59","author":"Horzinek","year":"1979","journal-title":"Arch. Virol."},{"key":"ref_97","first-page":"663","article-title":"Disseminated intravascular coagulation in experimentally induced feline infectious peritonitis","volume":"41","author":"Weiss","year":"1980","journal-title":"Am. J. Vet. Res."},{"key":"ref_98","first-page":"754","article-title":"Virion polypeptide specificity of immune complexes and antibodies in cats inoculated with feline infectious peritonitis virus","volume":"47","author":"Horzinek","year":"1986","journal-title":"Am. J. Vet. Res."},{"key":"ref_99","unstructured":"Pfeiffer, N. Prospects and problems of coronaviral serology. Proceedings of the Symposium New Perspectives on Prevention of Feline Infectious Peritonitis, Orlando, FL, USA."},{"key":"ref_100","unstructured":"Schroo, S. (1994). Kompetitiver Elisa zum Nachweis von L\u00f6slichen Immunkomplexen in Serum und Exsudaten Fip-Verd\u00e4chtiger Katzen. [Ph.D. Thesis, Justus-Liebig-Universit\u00e4t Gie\u00dfen]."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1128\/jvi.63.1.436-440.1989","article-title":"Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence","volume":"63","author":"Stoddart","year":"1989","journal-title":"J. Virol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0165-2427(98)00158-5","article-title":"Cellular composition, coronavirus antigen expression and production of specific antibodies in lesions in feline infectious peritonitis","volume":"65","author":"Kipar","year":"1998","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1354\/vp.42-3-321","article-title":"Morphologic features and development of granulomatous vasculitis in feline infectious peritonitis","volume":"42","author":"Kipar","year":"2005","journal-title":"Vet. Pathol."},{"key":"ref_104","first-page":"382","article-title":"Pathogenesis of feline infectious peritonitis: Nature and development of viremia","volume":"42","author":"Weiss","year":"1981","journal-title":"Am. J. Vet. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.vetmic.2006.11.026","article-title":"Absence of surface expression of feline infectious peritonitis virus (fipv) antigens on infected cells isolated from cats with fip","volume":"121","author":"Cornelissen","year":"2007","journal-title":"Vet. Microbiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0378-1135(98)00210-7","article-title":"Detection of feline coronaviruses by culture and reverse transcriptase-polymerase chain reaction of blood samples from healthy cats and cats with clinical feline infectious peritonitis","volume":"62","author":"Harbour","year":"1998","journal-title":"Vet. Microbiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jfms.2005.07.002","article-title":"Natural fcov infection: Cats with fip exhibit significantly higher viral loads than healthy infected cats","volume":"8","author":"Kipar","year":"2006","journal-title":"J. Feline Med. Surg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.virusres.2011.12.020","article-title":"Feline infectious peritonitis: Role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats","volume":"165","author":"Pedersen","year":"2012","journal-title":"Virus. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1099\/vir.0.020214-0","article-title":"Sites of feline coronavirus persistence in healthy cats","volume":"91","author":"Kipar","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jfms.2003.12.009","article-title":"Recommendations from workshops of the second international feline coronavirus\/feline infectious peritonitis symposium","volume":"6","author":"Addie","year":"2004","journal-title":"J. Feline Med. Surg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1699-0463.1989.tb00483.x","article-title":"Demonstration of feline infectious peritonitis virus in conjunctival epithelial cells from cats. A simple and reliable method for clinical veterinary virology screening","volume":"97","author":"Hok","year":"1989","journal-title":"Apmis"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1439-0450.1989.tb00610.x","article-title":"Eine modifikation der abc-methode (avidin-biotin-peroxidase-complex) f\u00fcr den nachweis von viralen antigenen bei der infektion der katze durch ein coronavirus (fip) und der infektion des hundes durch das parvovirus-typ 2","volume":"36","author":"Walter","year":"1989","journal-title":"J. Vet. Med. Ser. B"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/BF03546977","article-title":"A comparison between immunofluorescence staining on smears from membrana nictitans (m3 test), immunohistopathology and routine pathology in cats with suspected feline infectious peritonitis (fip)","volume":"32","author":"Hok","year":"1991","journal-title":"Acta. Vet. Scand."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1699-0463.1990.tb04985.x","article-title":"Demonstration of feline corona virus (fcv) antigen in organs of cats suspected of feline infectious peritonitis (fip) disease","volume":"98","author":"Hok","year":"1990","journal-title":"Apmis"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-2427(95)05459-J","article-title":"Immunohistological demonstration of feline infectious peritonitis virus antigen in paraffin-embedded tissues using feline ascites or murine monoclonal antibodies","volume":"49","author":"Tammer","year":"1995","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/1040638718755833","article-title":"A retrospective study of the neuropathology and diagnosis of naturally occurring feline infectious peritonitis","volume":"30","author":"Rissi","year":"2018","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1939-165X.2005.tb00063.x","article-title":"Sensitivity of tru-cut and fine needle aspiration biopsies of liver and kidney for diagnosis of feline infectious peritonitis","volume":"34","author":"Giordano","year":"2005","journal-title":"Vet. Clin. Pathol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/1040638718825280","article-title":"Immunocytochemistry of mesenteric lymph node fine-needle aspirates in the diagnosis of feline infectious peritonitis","volume":"31","author":"Felten","year":"2019","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Dunbar, D., Kwok, W., Graham, E., Armitage, A., Irvine, R., Johnston, P., McDonald, M., Montgomery, D., Nicolson, L., and Robertson, E. (2018). Diagnosis of non-effusive feline infectious peritonitis by reverse transcriptase quantitative pcr from mesenteric lymph node fine-needle aspirates. J. Feline Med. Surg., 1098612x18809165.","DOI":"10.1177\/1098612X18809165"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-3164.2008.00684.x","article-title":"Papular cutaneous lesions in a cat associated with feline infectious peritonitis","volume":"19","author":"Declercq","year":"2008","journal-title":"Vet. Dermatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/vop.12044","article-title":"Positive immunostaining for feline infectious peritonitis (fip) in a sphinx cat with cutaneous lesions and bilateral panuveitis","volume":"16","author":"Bauer","year":"2013","journal-title":"Vet. Ophthalmol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jfms.2007.08.006","article-title":"Priapism in a castrated cat associated with feline infectious peritonitis","volume":"10","author":"Rota","year":"2008","journal-title":"J. Feline Med. Surg."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"408","DOI":"10.7589\/2012-08-210","article-title":"Feline infectious peritonitis in a mountain lion (puma concolor), california, USA","volume":"49","author":"Stephenson","year":"2013","journal-title":"J. Wildl. Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jcpa.2014.12.006","article-title":"Positive immunolabelling for feline infectious peritonitis in an african lion (panthera leo) with bilateral panuveitis","volume":"152","author":"Mwase","year":"2015","journal-title":"J. Comp. Pathol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1748-5827.1993.tb02591.x","article-title":"Using direct immunofluorescence to detect coronaviruses in peritoneal and pleural effusions","volume":"34","author":"Cammarata","year":"1993","journal-title":"J. Small Anim. Pract."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/104063879901100411","article-title":"In vivo diagnosis of feline infectious peritonitis by comparison of protein content, cytology, and direct immunofluorescence test on peritoneal and pleural effusions","volume":"11","author":"Paltrinieri","year":"1999","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1177\/1098612X16630357","article-title":"Investigation into the utility of an immunocytochemical assay in body cavity effusions for diagnosis of feline infectious peritonitis","volume":"19","author":"Felten","year":"2017","journal-title":"J. Feline Med. Surg."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tvjl.2013.08.023","article-title":"Diagnostic utility of a direct immunofluorescence test to detect feline coronavirus antigen in macrophages in effusive feline infectious peritonitis","volume":"198","author":"Litster","year":"2013","journal-title":"Vet. J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/1098612X13491960","article-title":"Immunocytochemical demonstration of feline infectious peritonitis virus within cerebrospinal fluid macrophages","volume":"15","author":"Ives","year":"2013","journal-title":"J. Feline Med. Surg."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/1098612X16640839","article-title":"Diagnostic utility of cerebrospinal fluid immunocytochemistry for diagnosis of feline infectious peritonitis manifesting in the central nervous system","volume":"19","author":"Gruendl","year":"2017","journal-title":"J. Feline Med. Surg."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/vop.12324","article-title":"Causes of endogenous uveitis in cats presented to referral clinics in north carolina","volume":"19","author":"Jinks","year":"2016","journal-title":"Vet. Ophthalmol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/vop.12474","article-title":"Utility of an immunocytochemical assay using aqueous humor in the diagnosis of feline infectious peritonitis","volume":"21","author":"Felten","year":"2018","journal-title":"Vet. Ophthalmol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0378-1135(94)90078-7","article-title":"Detection of feline coronaviruses in cell cultures and in fresh and fixed feline tissues using polymerase chain reaction","volume":"42","author":"Li","year":"1994","journal-title":"Vet. Microbiol."},{"key":"ref_134","first-page":"2580","article-title":"Pathogenicity studies of feline coronavirus isolates 79-1146 and 79-1683","volume":"45","author":"Pedersen","year":"1984","journal-title":"Am. J. Vet. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13567-017-0467-9","article-title":"Limitations of using feline coronavirus spike protein gene mutations to diagnose feline infectious peritonitis","volume":"48","author":"Barker","year":"2017","journal-title":"Vet. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.vetimm.2006.02.004","article-title":"Natural feline coronavirus infection: Differences in cytokine patterns in association with the outcome of infection","volume":"112","author":"Kipar","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1297-9716-45-49","article-title":"Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis","volume":"45","author":"Porter","year":"2014","journal-title":"Vet. Res."},{"key":"ref_138","unstructured":"Addie, D.D., Bel\u00e1k, S., Boucraut-Baralon, C., Egberink, H., Frymus, T., Gruffydd-Jones, T., Hartmann, K., Hofmann-Lehmann, R., Hosie, M.J., and Lloret, A. (2019, August 08). Feline Infectious Peritonitis. Available online: http:\/\/www.abcdcatsvets.org\/feline-infectious-peritonitis\/."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jviromet.2012.01.022","article-title":"Detection of subgenomic mrna of feline coronavirus by real-time polymerase chain reaction based on primer-probe energy transfer (p-sg-qpcr)","volume":"181","author":"Hornyak","year":"2012","journal-title":"J. Virol. Methods"},{"key":"ref_140","first-page":"436","article-title":"Sequencing of 3c and spike genes in feline infectious peritonitis: Which samples are the most relevant for analysis? A retrospective study of 33 cases from 2008 to 2014","volume":"30","author":"Freiche","year":"2016","journal-title":"J. Vet. Intern. Med."},{"key":"ref_141","unstructured":"Felten, S., Emmler, L., Matiasek, K., Balzer, H.-J., Pantchev, N., Leutenegger, C.M., and Hartmann, K. (October, January 30). Detection of mutated and non-mutated feline coronavirus in tissues and body fluids of cats with feline infectious peritonitis. Proceedings of the 2018 ISCAID Symposium, Portland, OR, USA."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/1098612X18762883","article-title":"Detection of feline coronavirus mutations in paraffin-embedded tissues in cats with feline infectious peritonitis and controls","volume":"21","author":"Sangl","year":"2019","journal-title":"J. Feline Med. Surg."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1128\/jcm.33.3.684-689.1995","article-title":"Detection of feline coronavirus rna in feces, tissues, and body fluids of naturally infected cats by reverse transcriptase pcr","volume":"33","author":"Herrewegh","year":"1995","journal-title":"J. Clin. Microbiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/viro.1997.8663","article-title":"Persistence and evolution of feline coronavirus in a closed cat-breeding colony","volume":"234","author":"Herrewegh","year":"1997","journal-title":"Virology"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/01652176.1995.9694576","article-title":"Fip, easy to diagnose?","volume":"17","author":"Egberink","year":"1995","journal-title":"Vet. Q."},{"key":"ref_146","first-page":"74","article-title":"Detection of feline coronavirus using rt pcr: Basis for the study of the pathogenesis of feline infectious peritonitis (fip)","volume":"138","author":"Fehr","year":"1996","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/1098612X17705227","article-title":"Cross-sectional quantitative rt-pcr study of feline coronavirus viremia and replication in peripheral blood of healthy shelter cats in southern california","volume":"20","author":"Fish","year":"2018","journal-title":"J. Feline Med. Surg."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jviromet.2004.11.012","article-title":"A mrna pcr for the diagnosis of feline infectious peritonitis","volume":"124","author":"Simons","year":"2005","journal-title":"J. Virol. Methods"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/1098612X15625354","article-title":"Comparison of real-time reverse transcriptase polymerase chain reaction of peripheral blood mononuclear cells, serum and cell-free body cavity effusion for the diagnosis of feline infectious peritonitis","volume":"19","author":"Doenges","year":"2017","journal-title":"J. Feline Med. Surg."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3923\/javaa.2011.18.22","article-title":"Evaluation of feline coronavirus viraemia in clinically healthy and ill cats with feline infectious peritonitis","volume":"10","author":"Sharif","year":"2011","journal-title":"J. Anim. Vet. Adv."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jfms.2007.03.002","article-title":"The detection of feline coronaviruses in blood samples from cats by mrna rt-pcr","volume":"9","author":"Pinar","year":"2007","journal-title":"J. Feline Med. Surg."},{"key":"ref_152","first-page":"1193","article-title":"Effect of feline interferon-omega on the survival time and quality of life of cats with feline infectious peritonitis","volume":"21","author":"Ritz","year":"2007","journal-title":"J. Vet. Intern. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"14122","DOI":"10.1128\/JVI.79.22.14122-14130.2005","article-title":"Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein","volume":"79","author":"Rottier","year":"2005","journal-title":"J. Virol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1007\/s00705-005-0598-6","article-title":"Replication of feline coronaviruses in peripheral blood monocytes","volume":"150","author":"Dewerchin","year":"2005","journal-title":"Arch. Virol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jviromet.2017.01.009","article-title":"Reverse transcriptase loop-mediated isothermal amplification for the detection of feline coronavirus","volume":"243","author":"Stranieri","year":"2017","journal-title":"J. Virol. Methods"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/1098612X15623824","article-title":"Detection of feline coronavirus spike gene mutations as a tool to diagnose feline infectious peritonitis","volume":"19","author":"Felten","year":"2017","journal-title":"J. Feline Med. Surg."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Felten, S., Leutenegger, C.M., Balzer, H.J., Pantchev, N., Matiasek, K., Wess, G., Egberink, H., and Hartmann, K. (2017). Sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction detecting feline coronavirus mutations in effusion and serum\/plasma of cats to diagnose feline infectious peritonitis. BMC Vet. Res., 13.","DOI":"10.1186\/s12917-017-1147-8"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1128\/jcm.35.3.673-675.1997","article-title":"Development of a nested pcr assay for detection of feline infectious peritonitis virus in clinical specimens","volume":"35","author":"Gamble","year":"1997","journal-title":"J. Clin. Microbiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jviromet.2018.03.003","article-title":"Detection of feline coronavirus in effusions of cats with and without feline infectious peritonitis using loop-mediated isothermal amplification","volume":"256","author":"Gunther","year":"2018","journal-title":"J. Virol. Methods"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/1098612X15606957","article-title":"Feline coronavirus quantitative reverse transcriptase polymerase chain reaction on effusion samples in cats with and without feline infectious peritonitis","volume":"19","author":"Longstaff","year":"2017","journal-title":"J. Feline Med. Surg."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1292\/jvms.13-0094","article-title":"Detection of ascitic feline coronavirus rna from cats with clinically suspected feline infectious peritonitis","volume":"75","author":"Soma","year":"2013","journal-title":"J. Vet. Med. Sci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/1098612X15574757","article-title":"Detection of feline coronavirus in cerebrospinal fluid for diagnosis of feline infectious peritonitis in cats with and without neurological signs","volume":"18","author":"Doenges","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_163","first-page":"399","article-title":"The blood-brain barrier and its role in inflammation","volume":"14","author":"Webb","year":"2000","journal-title":"J. Vet. Intern. Med."},{"key":"ref_164","unstructured":"Felten, S., Sangl, L., Matiasek, K., Leutenegger, C.M., Pantchev, N., Balzer, H.-J., and Hartmann, K. (2016, January 16\u201319). Comparison of different diagnostic methods in aqueous humor to diagnose feline infectious peritonitis. Proceedings of the 2016 ISCAID Symposium, Bristol, UK."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/rna.8.2.15013","article-title":"Coronaviruses: An rna proofreading machine regulates replication fidelity and diversity","volume":"8","author":"Denison","year":"2011","journal-title":"RNA Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1053\/rvsc.1999.0368","article-title":"Preliminary studies on feline coronavirus distribution in naturally and experimentally infected cats","volume":"68","author":"Kiss","year":"2000","journal-title":"Res. Vet. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"8560691","DOI":"10.1155\/2016\/8560691","article-title":"Feline coronavirus 3c protein: A candidate for a virulence marker?","volume":"2016","author":"Hora","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1128\/jcm.34.12.3180-3184.1996","article-title":"Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus","volume":"34","author":"Poland","year":"1996","journal-title":"J. Clin. Microbiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.rvsc.2014.07.016","article-title":"Mutations in the 3c and 7b genes of feline coronavirus in spontaneously affected fip cats","volume":"97","author":"Borschensky","year":"2014","journal-title":"Res. Vet. Sci."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.vetmic.2014.07.020","article-title":"Mutations of 3c and spike protein genes correlate with the occurrence of feline infectious peritonitis","volume":"173","author":"Stallkamp","year":"2014","journal-title":"Vet. Microbiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/v1020166","article-title":"Significance of coronavirus mutants in feces and diseased tissues of cats suffering from feline infectious peritonitis","volume":"1","author":"Pedersen","year":"2009","journal-title":"Viruses"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1099\/vir.0.016485-0","article-title":"Feline infectious peritonitis: Insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene","volume":"91","author":"Chang","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.rvsc.2013.08.011","article-title":"3c protein of feline coronavirus inhibits viral replication independently of the autophagy pathway","volume":"95","author":"Hsieh","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"6258","DOI":"10.1128\/JVI.00189-12","article-title":"Molecular characterization of feline infectious peritonitis virus strain df-2 and studies of the role of orf3abc in viral cell tropism","volume":"86","author":"Balint","year":"2012","journal-title":"J. Virol."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Balint, A., Farsang, A., Zadori, Z., and Belak, S. (2014). Comparative in vivo analysis of recombinant type ii feline coronaviruses with truncated and completed orf3 region. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088758"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.vetmic.2012.10.032","article-title":"The role of accessory proteins in the replication of feline infectious peritonitis virus in peripheral blood monocytes","volume":"162","author":"Dedeurwaerder","year":"2013","journal-title":"Vet. Microbiol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1006\/viro.1995.1520","article-title":"The molecular genetics of feline coronaviruses: Comparative sequence analysis of the orf7a\/7b transcription unit of different biotypes","volume":"212","author":"Herrewegh","year":"1995","journal-title":"Virology"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.virusres.2010.12.020","article-title":"Mutation of neutralizing\/antibody-dependent enhancing epitope on spike protein and 7b gene of feline infectious peritonitis virus: Influences of viral replication in monocytes\/macrophages and virulence in cats","volume":"156","author":"Takano","year":"2011","journal-title":"Virus. Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1099\/vir.0.058743-0","article-title":"Orf7-encoded accessory protein 7a of feline infectious peritonitis virus as a counteragent against ifn-alpha-induced antiviral response","volume":"95","author":"Dedeurwaerder","year":"2014","journal-title":"J. Gen. Virol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0378-1135(01)00354-6","article-title":"Deletions in the 7a orf of feline coronavirus associated with an epidemic of feline infectious peritonitis","volume":"81","author":"Kennedy","year":"2001","journal-title":"Vet. Microbiol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jfms.2008.09.004","article-title":"Field strain feline coronaviruses with small deletions in orf7b associated with both enteric infection and feline infectious peritonitis","volume":"11","author":"Lin","year":"2009","journal-title":"J. Feline Med. Surg."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/v4040557","article-title":"Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence","volume":"4","author":"Gallagher","year":"2012","journal-title":"Viruses"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"8801","DOI":"10.1128\/JVI.77.16.8801-8811.2003","article-title":"The coronavirus spike protein is a class i virus fusion protein: Structural and functional characterization of the fusion core complex","volume":"77","author":"Bosch","year":"2003","journal-title":"J. Virol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.virol.2017.12.027","article-title":"Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function","volume":"517","author":"Jaimes","year":"2018","journal-title":"Virology"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3201\/eid1807.120143","article-title":"Spike protein fusion peptide and feline coronavirus virulence","volume":"18","author":"Chang","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3201\/eid1907.121094","article-title":"Mutation in spike protein cleavage site and pathogenesis of feline coronavirus","volume":"19","author":"Licitra","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1099\/vir.0.000084","article-title":"Genotyping coronaviruses associated with feline infectious peritonitis","volume":"96","author":"Lewis","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_188","unstructured":"Felten, S., Leutenegger, C.M., Balzer, H.J., Pantchev, N., Matiasek, K., Sangl, L., Doenges, S., Gruendl, S., Fischer, A., and Hartmann, K. (2017, January 14\u201316). Evaluation of a discriminative realtime rt-pcr in cerebrospinal fluid for the diagnosis of feline infectious peritonitis. Proceedings of the 27th ECVIM-CA Congress, St. Julian\u2019s, Malta."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/11\/11\/1068\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:34:46Z","timestamp":1760189686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/11\/11\/1068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":188,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["v11111068"],"URL":"https:\/\/doi.org\/10.3390\/v11111068","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]}}}