{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:45:19Z","timestamp":1770065119215,"version":"3.49.0"},"reference-count":41,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["10110713 and 10110802"],"award-info":[{"award-number":["10110713 and 10110802"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Daido Welfare Foundation","award":["2019-18"],"award-info":[{"award-number":["2019-18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Between 2011 and 2018, 518 respiratory adenovirus infections were diagnosed in a pediatric clinic in Shizuoka, Japan. Detection and typing were performed by partial sequencing of both hexon- and fiber-coding regions which identified: adenovirus type 1 (Ad-1, n = 85), Ad-2 (n = 160), Ad-3 (n = 193), Ad-4 (n = 18), Ad-5 (n = 27), Ad-11 (n = 2), Ad-54 (n = 3), and Ad-56 (n = 1). Considering previous reports of the circulation of an endemic recombinant Ad-2, e.g., Ad-89, 100 samples typed as Ad-2 were randomly selected for further molecular typing by sequencing the penton base-coding region. Despite the high nucleotide sequence conservation in the penton base- coding region, 27 samples showed 98% identity to Ad-2. Furthermore, 14 samples showed 97.7% identity to Ad-2 and 99.8% identity to Ad-89, while the remaining 13 samples showed an average 98% pairwise identity to other Ad-C types and clustered with Ad-5. The samples typed as Ad-89 (n = 14) and as a recombinant Ad type (P5H2F2) (n = 13) represented 27% of cases originally diagnosed as Ad-2, and were detected sporadically. Therefore, two previously uncharacterized types in Japan, Ad-89 and a recombinant Ad-C, were shown to circulate in children. This study creates a precedent to evaluate the epidemiology and divergence among Ad-C types by comprehensively considering the type classification of adenoviruses.<\/jats:p>","DOI":"10.3390\/v11121131","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T10:41:44Z","timestamp":1575628904000},"page":"1131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pediatric Infections by Human mastadenovirus C Types 2, 89, and a Recombinant Type Detected in Japan between 2011 and 2018"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8306-9553","authenticated-orcid":false,"given":"Kenichiro","family":"Takahashi","sequence":"first","affiliation":[{"name":"Division 4, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan"},{"name":"Department of Pediatrics, Tokyo Women\u2019s Medical University Medical Center East, Tokyo 116-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-2120","authenticated-orcid":false,"given":"Gabriel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Kobayashi Pediatric Clinic, Fujieda 426-0067, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-6278","authenticated-orcid":false,"given":"Nozomu","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"Division 4, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-6209","authenticated-orcid":false,"given":"Michael J.","family":"Carr","sequence":"additional","affiliation":[{"name":"National Virus Reference Laboratory, School of Medicine, University College Dublin, Dublin D04 V1W8, Ireland"},{"name":"Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo 001-0020, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Konagaya","sequence":"additional","affiliation":[{"name":"Division 4, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Nojiri","sequence":"additional","affiliation":[{"name":"Division 4, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan"},{"name":"Kobayashi Pediatric Clinic, Fujieda 426-0067, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Ogi","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Division, Hyogo Prefectural Institute of Public Health Science, Kakogawa 675-0003, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-4349","authenticated-orcid":false,"given":"Tsuguto","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Division 4, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"ref_1","unstructured":"King, A.M.Q., Adams, M.J., Lefkowitz, E.J., and Carstens, E.B. 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