{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T08:57:41Z","timestamp":1779008261664,"version":"3.51.4"},"reference-count":16,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Diasorin Iberia","award":["MVP280\/18"],"award-info":[{"award-number":["MVP280\/18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The aim of this study is to evaluate the performance characteristics of the LIAISON XL Zika Capture IgM II. For this purpose we tested 128 samples obtained from recent infections caused by the Zika (ZIKV; 74 samples), dengue (DENV; 10 samples), chikungunya (CHIK V; 11 samples), rubella (RUBV; 10 samples) and measles (MeV; 10 samples) viruses, as well as human parvovirus B19 (HPVB19; 13 samples). The results of the assay under evaluation are compared with those obtained from an indirect immunofluorescence (IIF) assay, and the discrepancies are resolved by considering other laboratory results (PCR and a plaque-reduction neutralization test). The LIAISON showed excellent sensitivity (100%). The specificity (91.25%) was hampered by some false-positive results in recent dengue virus, chikungunya virus, measles virus and human parvovirus B19 infections. The method evaluated is adequate, but the low specificity makes it necessary to consider the clinical and epidemiological contexts of patients, as well as other laboratory results.<\/jats:p>","DOI":"10.3390\/v12010069","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T03:59:57Z","timestamp":1578455997000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of the LIAISON XL Zika Capture IgM II for the Diagnosis of Zika Virus Infections"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4553-5423","authenticated-orcid":false,"given":"Mayte","family":"P\u00e9rez-Olmeda","sequence":"first","affiliation":[{"name":"Laboratorio de Serolog\u00eda y Arbovirus, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, 28220 Majadahonda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Paz","family":"S\u00e1nchez-Seco","sequence":"additional","affiliation":[{"name":"Laboratorio de Serolog\u00eda y Arbovirus, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, 28220 Majadahonda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9872-3316","authenticated-orcid":false,"given":"Ana","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Serolog\u00eda y Arbovirus, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, 28220 Majadahonda, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Balfag\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Serolog\u00eda y Arbovirus, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, 28220 Majadahonda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Laboratorio de Serolog\u00eda y Arbovirus, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, 28220 Majadahonda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Murillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Serolog\u00eda y Arbovirus, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, 28220 Majadahonda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora","family":"Minguito","sequence":"additional","affiliation":[{"name":"Laboratorio de Serolog\u00eda y Arbovirus, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, 28220 Majadahonda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6981-1261","authenticated-orcid":false,"given":"Fernando","family":"de Ory","sequence":"additional","affiliation":[{"name":"Laboratorio de Serolog\u00eda y Arbovirus, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, 28220 Majadahonda, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. 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