{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:57:55Z","timestamp":1777478275068,"version":"3.51.4"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Medicine of the 294  University of Cologne","award":["Koeln Fortune Program"],"award-info":[{"award-number":["Koeln Fortune Program"]}]},{"name":"ESTHER Germany","award":["Hospital Partnership Program"],"award-info":[{"award-number":["Hospital Partnership Program"]}]},{"name":"German Federal Ministry of Education and Research","award":["Project No. 01KA1102"],"award-info":[{"award-number":["Project No. 01KA1102"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>In the post-polio eradication era, increasing attention is given to non-polio enteroviruses. Most of the data about enteroviruses in sub-Saharan Africa are related to acute flaccid paralysis surveillance and target the pediatric population. This study aimed to investigate the presence of enterovirus in PLHIV (people living with HIV) and HIV-negative individuals in Ghana. Stool samples from HIV-positive individuals (n = 250) and healthy blood donors (n = 102) attending the Komfo Anokye Teaching Hospital in Kumasi, Ghana, were screened by real-time PCR for enterovirus. Molecular typing of the VP1 region was performed. Enterovirus-positive samples were tested for norovirus, adenovirus, rotavirus, sapovirus, and cosaviruses. Twenty-six out of 250 HIV-positive subjects (10.4%) and 14 out of 102 HIV-negative individuals (13.7%) were detected enterovirus-positive, not showing a significant different infection rate between the two groups. HIV-negative individuals were infected with Enterovirus C strains only. HIV-positive participants were detected positive for species Enterovirus A, Enterovirus B, and Enterovirus C. Co-infections with other viral enteric pathogens were almost exclusively detected among HIV-positive participants. Overall, the present study provides the first data about enteroviruses within HIV-positive and HIV-negative adults living in Ghana.<\/jats:p>","DOI":"10.3390\/v12020221","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T04:06:01Z","timestamp":1582085161000},"page":"221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana"],"prefix":"10.3390","volume":"12","author":[{"given":"Veronica","family":"Di Cristanziano","sequence":"first","affiliation":[{"name":"Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, 50935 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Weimer","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, 50935 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sindy","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"National Reference Centre for Poliomyelitis and Enteroviruses, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred Stephen","family":"Sarfo","sequence":"additional","affiliation":[{"name":"Kwame Nkrumah University of Science and Technology, Kumasi 00233, Ghana"},{"name":"Komfo Anokye Teaching Hospital, Kumasi 00233, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Dompreh","sequence":"additional","affiliation":[{"name":"Komfo Anokye Teaching Hospital, Kumasi 00233, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4139-7214","authenticated-orcid":false,"given":"Lucio-Garcia","family":"Cesar","sequence":"additional","affiliation":[{"name":"Autonomous University of the Mexico State, 50000 Toluca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-3026","authenticated-orcid":false,"given":"Elena","family":"Knops","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, 50935 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Heger","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, 50935 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maike","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, 50935 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, 50935 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty","family":"Norman","sequence":"additional","affiliation":[{"name":"Kwame Nkrumah University of Science and Technology, Kumasi 00233, Ghana"},{"name":"Komfo Anokye Teaching Hospital, Kumasi 00233, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-0222","authenticated-orcid":false,"given":"Richard Odame","family":"Phillips","sequence":"additional","affiliation":[{"name":"Kwame Nkrumah University of Science and Technology, Kumasi 00233, Ghana"},{"name":"Komfo Anokye Teaching Hospital, Kumasi 00233, Ghana"},{"name":"Kumasi Center for Collaborative Research in Tropical Medicine, Kumasi 00233, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-4492","authenticated-orcid":false,"given":"Torsten","family":"Feldt","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-0326","authenticated-orcid":false,"given":"Kirsten Alexandra","family":"Eberhardt","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and I. 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