{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:16:01Z","timestamp":1787030161415,"version":"build-2736575974"},"reference-count":112,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T00:00:00Z","timestamp":1589068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 virus that impacts the lower respiratory tract. The spectrum of symptoms ranges from asymptomatic infections to mild respiratory symptoms to the lethal form of COVID-19 which is associated with severe pneumonia, acute respiratory distress, and fatality. To address this global crisis, up-to-date information on viral genomics and transcriptomics is crucial for understanding the origins and global dispersion of the virus, providing insights into viral pathogenicity, transmission, and epidemiology, and enabling strategies for therapeutic interventions, drug discovery, and vaccine development. Therefore, this review provides a comprehensive overview of COVID-19 epidemiology, genomic etiology, findings from recent transcriptomic map analysis, viral-human protein interactions, molecular diagnostics, and the current status of vaccine and novel therapeutic intervention development. Moreover, we provide an extensive list of resources that will help the scientific community access numerous types of databases related to SARS-CoV-2 OMICs and approaches to therapeutics related to COVID-19 treatment.<\/jats:p>","DOI":"10.3390\/v12050526","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T10:01:18Z","timestamp":1589191278000},"page":"526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":192,"title":["SARS-CoV-2\/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-5803","authenticated-orcid":false,"given":"Mohammed","family":"Uddin","sequence":"first","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE"},{"name":"The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1081-3756","authenticated-orcid":false,"given":"Farah","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir A.","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1687-6587","authenticated-orcid":false,"given":"Tom","family":"Loney","sequence":"additional","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Al Suwaidi","sequence":"additional","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed H. Hassan","family":"Al-Marzouqi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afaf","family":"Kamal Eldin","sequence":"additional","affiliation":[{"name":"Department of Food, Nutrition and Health, United Arab Emirates University, Al Ain, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel","family":"Alsabeeha","sequence":"additional","affiliation":[{"name":"Ministry of Health and Prevention, Dubai, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Adrian","sequence":"additional","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Stefanini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Healthcare Engineering Innovation Center (HEIC), Khalifa University, Abu Dhabi, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-571X","authenticated-orcid":false,"given":"Norbert","family":"Nowotny","sequence":"additional","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE"},{"name":"Viral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1213-4546","authenticated-orcid":false,"given":"Alawi","family":"Alsheikh-Ali","sequence":"additional","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-198X","authenticated-orcid":false,"given":"Abiola C.","family":"Senok","sequence":"additional","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization, WHO (2020, May 09). 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