{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:54:26Z","timestamp":1790646866872,"version":"4.1.0"},"reference-count":113,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Investissement d\u2019Avenir, Laboratoire d\u2019Excellence (LabEx). French research program: Integrative Biology of Emerging Infectious Diseases.","award":["ANR10-LBX-62 IBEID"],"award-info":[{"award-number":["ANR10-LBX-62 IBEID"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Infections due to arboviruses (arthropod-borne viruses) have dramatically increased worldwide during the last few years. In humans, symptoms associated with acute infection of most arboviruses are often described as \u201cdengue-like syndrome\u201d, including fever, rash, conjunctivitis, arthralgia, and muscular symptoms such as myalgia, myositis, or rhabdomyolysis. In some cases, muscular symptoms may persist over months, especially following flavivirus and alphavirus infections. However, in humans the cellular targets of infection in muscle have been rarely identified. Animal models provide insights to elucidate pathological mechanisms through studying viral tropism, viral-induced inflammation, or potential viral persistence in the muscle compartment. The tropism of arboviruses for muscle cells as well as the viral-induced cytopathic effect and cellular alterations can be confirmed in vitro using cellular models. This review describes the link between muscle alterations and arbovirus infection, and the underlying mechanisms.<\/jats:p>","DOI":"10.3390\/v12060616","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T05:16:14Z","timestamp":1591679774000},"page":"616","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Arboviruses and Muscle Disorders: From Disease to Cell Biology"],"prefix":"10.3390","volume":"12","author":[{"given":"Claudia","family":"Filippone","sequence":"first","affiliation":[{"name":"Unit of Epidemiology and Physiopathology of Oncogenic Viruses, Institut Pasteur, 75015 Paris, France"},{"name":"Centre National de la Recherche Scientifique (CNRS) UMR 3569, 75015 Paris, France"},{"name":"Virology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-7564","authenticated-orcid":false,"given":"Vincent","family":"Legros","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Physiopathology of Oncogenic Viruses, Institut Pasteur, 75015 Paris, France"},{"name":"Centre National de la Recherche Scientifique (CNRS) UMR 3569, 75015 Paris, France"},{"name":"Universit\u00e9 de Paris, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Jeannin","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Physiopathology of Oncogenic Viruses, Institut Pasteur, 75015 Paris, France"},{"name":"Centre National de la Recherche Scientifique (CNRS) UMR 3569, 75015 Paris, France"},{"name":"Universit\u00e9 de Paris, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Choumet","sequence":"additional","affiliation":[{"name":"CIBU Unit, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Butler-Browne","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institut de Myologie, UMRS 974, Center for Research in Myology, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-251X","authenticated-orcid":false,"given":"Jim","family":"Zoladek","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Physiopathology of Oncogenic Viruses, Institut Pasteur, 75015 Paris, France"},{"name":"Centre National de la Recherche Scientifique (CNRS) UMR 3569, 75015 Paris, France"},{"name":"Universit\u00e9 de Paris, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Mouly","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institut de Myologie, UMRS 974, Center for Research in Myology, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gessain","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Physiopathology of Oncogenic Viruses, Institut Pasteur, 75015 Paris, France"},{"name":"Centre National de la Recherche Scientifique (CNRS) UMR 3569, 75015 Paris, France"},{"name":"Universit\u00e9 de Paris, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Emmanuel","family":"Ceccaldi","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Physiopathology of Oncogenic Viruses, Institut Pasteur, 75015 Paris, France"},{"name":"Centre National de la Recherche Scientifique (CNRS) UMR 3569, 75015 Paris, France"},{"name":"Universit\u00e9 de Paris, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/nature06536","article-title":"Global trends in emerging infectious diseases","volume":"451","author":"Jones","year":"2008","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.onehlt.2017.06.001","article-title":"Emerging arboviruses: Why today?","volume":"4","author":"Gould","year":"2017","journal-title":"One Health"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Schuffenecker, I., Iteman, I., Michault, A., Murri, S., Frangeul, L., Vaney, M.-C., Lavenir, R., Pardigon, N., Reynes, J.-M., and Pettinelli, F. 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