{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:44:22Z","timestamp":1790811862526,"version":"4.1.0"},"reference-count":281,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_184766\/1"],"award-info":[{"award-number":["310030_184766\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.<\/jats:p>","DOI":"10.3390\/v12060662","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T10:43:58Z","timestamp":1592563438000},"page":"662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["The Interplay between Adeno-Associated Virus and Its Helper Viruses"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-0735","authenticated-orcid":false,"given":"Anita F.","family":"Meier","sequence":"first","affiliation":[{"name":"Institute of Virology, University of Zurich, CH-8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornel","family":"Fraefel","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Zurich, CH-8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-2430","authenticated-orcid":false,"given":"Michael","family":"Seyffert","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Zurich, CH-8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Atchison, R.W., Casto, B.C., and Hammon, W.M. (1965). Adenovirus-Associated Defective Virus Particles. Science.","DOI":"10.1126\/science.149.3685.754"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1073\/pnas.55.6.1467","article-title":"Studies of small DNA viruses found in various adenovirus preparations: Physical, biological, and immunological characteristics","volume":"55","author":"Hoggan","year":"1966","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/mt.2011.287","article-title":"The AAV Vector Toolkit: Poised at the Clinical Crossroads","volume":"20","author":"Asokan","year":"2012","journal-title":"Mol. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/JVI.76.2.791-801.2002","article-title":"Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity","volume":"76","author":"Rabinowitz","year":"2002","journal-title":"J. Virol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1086\/595830","article-title":"Worldwide Epidemiology of Neutralizing Antibodies to Adeno-Associated Viruses","volume":"199","author":"Calcedo","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/gt.2014.47","article-title":"Neutralizing antibodies against AAV2, AAV5 and AAV8 in healthy and HIV-1-infected subjects in China: Implications for gene therapy using AAV vectors","volume":"21","author":"Liu","year":"2014","journal-title":"Gene Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/hgtb.2012.243","article-title":"Pre-existing Anti\u2013Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy","volume":"24","author":"Joergensen","year":"2013","journal-title":"Hum. Gene Ther. Methods"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0042-6822(70)90248-5","article-title":"The Role of Herpesvirus in Adeno-Associated Virus Replication in Vitro","volume":"42","author":"Atchison","year":"1970","journal-title":"Virology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0042-6822(84)90272-1","article-title":"Analysis of proteins, helper dependence, and seroepidemiology of a new human parvovirus","volume":"134","author":"Biederlack","year":"1984","journal-title":"Virology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1128\/JVI.74.8.3494-3504.2000","article-title":"Productive Replication of Adeno-Associated Virus Can Occur in Human Papillomavirus Type 16 (HPV-16) Episome-Containing Keratinocytes and Is Augmented by the HPV-16 E2 Protein","volume":"74","author":"Ogston","year":"2000","journal-title":"J. Virol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1128\/JVI.80.4.1874-1885.2006","article-title":"Scalable Generation of High-Titer Recombinant Adeno-Associated Virus Type 5 in Insect Cells","volume":"80","author":"Urabe","year":"2006","journal-title":"J. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e00710","DOI":"10.1128\/JVI.00710-17","article-title":"Human Bocavirus 1 Is a Novel Helper for Adeno-associated Virus Replication","volume":"91","author":"Wang","year":"2017","journal-title":"J. Virol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ijc.2910360114","article-title":"Selective DNA-amplification induced by carcinogens (initiators): Evidence for a role of proteases and DNA polymerase alpha","volume":"36","author":"Heilbronn","year":"1985","journal-title":"Int. J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ijc.2910320512","article-title":"Inhibition of initiator-induced SV40 gene amplification in SV40-transformed Chinese hamster cells by infection with a defective parvovirus","volume":"32","author":"Schlehofer","year":"1983","journal-title":"Int. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1128\/jvi.61.4.972-981.1987","article-title":"Replication of adeno-associated virus in synchronized cells without the addition of a helper virus","volume":"61","author":"Yakobson","year":"1987","journal-title":"J. Virol."},{"key":"ref_16","first-page":"3123","article-title":"DNA amplification of adeno-associated virus as a response to cellular genotoxic stress","volume":"48","author":"Yalkinoglu","year":"1988","journal-title":"Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0042-6822(03)00432-X","article-title":"Double strand interaction is the predominant pathway for intermolecular recombination of adeno-associated viral genomes","volume":"313","author":"Yue","year":"2003","journal-title":"Virology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1089\/hum.2009.214","article-title":"Molecular Analysis of Vector Genome Structures After Liver Transduction by Conventional and Self-Complementary Adeno-Associated Viral Serotype Vectors in Murine and Nonhuman Primate Models","volume":"21","author":"Sun","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev-virology-031413-085355","article-title":"AAV-Mediated Gene Therapy for Research and Therapeutic Purposes","volume":"1","author":"Samulski","year":"2014","journal-title":"Annu. Rev. Virol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1128\/jvi.8.5.766-770.1971","article-title":"Structural Proteins of Adenovirus-Associated Viruses","volume":"8","author":"Rose","year":"1971","journal-title":"J. Virol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10405","DOI":"10.1073\/pnas.162250899","article-title":"The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy","volume":"99","author":"Xie","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/embo-reports\/kve234","article-title":"Electron cryo-microscopy and image reconstruction of adeno-associated virus type 2 empty capsids","volume":"2","author":"Kronenberg","year":"2001","journal-title":"Embo Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1128\/jvi.45.2.555-564.1983","article-title":"Nucleotide sequence and organization of the adeno-associated virus 2 genome","volume":"45","author":"Srivastava","year":"1983","journal-title":"J. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1073\/pnas.76.11.5567","article-title":"Spliced adenovirus-associated virus RNA","volume":"76","author":"Laughlin","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1128\/jvi.36.1.79-92.1980","article-title":"Transcripts of the adeno-associated virus genome: Mapping of the major RNAs","volume":"36","author":"Green","year":"1980","journal-title":"J. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0092-8674(80)90171-3","article-title":"Definition of a novel promoter for the major adenovirus-associated virus mRNA","volume":"22","author":"Green","year":"1980","journal-title":"Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/jvi.41.2.518-526.1982","article-title":"Mapping of the 5\u2019 termini of two adeno-associated virus 2 RNAs in the left half of the genome","volume":"41","author":"Lusby","year":"1982","journal-title":"J. Virol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1128\/jvi.60.3.823-832.1986","article-title":"Identification of the trans-acting Rep proteins of adeno-associated virus by antibodies to a synthetic oligopeptide","volume":"60","author":"Mendelson","year":"1986","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1128\/jvi.62.9.3356-3363.1988","article-title":"Alternate mRNA splicing is required for synthesis of adeno-associated virus VP1 capsid protein","volume":"62","author":"Trempe","year":"1988","journal-title":"J. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10220","DOI":"10.1073\/pnas.1001673107","article-title":"A viral assembly factor promotes AAV2 capsid formation in the nucleolus","volume":"107","author":"Sonntag","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/jvi.34.2.402-409.1980","article-title":"Nucleotide Sequence of the Inverted Terminal Repetition in Adeno-Associated Virus DNA","volume":"34","author":"Lusby","year":"1980","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1073\/pnas.79.6.2077","article-title":"Cloning of adeno-associated virus into pBR322: Rescue of intact virus from the recombinant plasmid in human cells","volume":"79","author":"Samulski","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0092-8674(83)90342-2","article-title":"Rescue of adeno-associated virus from recombinant plasmids: Gene correction within the terminal repeats of AAV","volume":"33","author":"Samulski","year":"1983","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Senapathy, P., Tratschin, J.-D., and Carter, B.J. (1984). Replication of Adeno-associated virus DNA. J. Mol. Biol.","DOI":"10.1016\/0022-2836(84)90303-6"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Berns, K.I. (2020). The Unusual Properties of the AAV Inverted Terminal Repeat. Hum. Gene Ther.","DOI":"10.1089\/hum.2020.017"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1128\/jvi.9.2.394-396.1972","article-title":"Separation of Two Types of Adeno-Associated Virus Particles Containing Complementary Polynucleotide Chains","volume":"9","author":"Berns","year":"1972","journal-title":"J. Virol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1128\/jvi.61.10.3096-3101.1987","article-title":"A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication","volume":"61","author":"Samulski","year":"1987","journal-title":"J. Virol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/sj.mt.6300397","article-title":"Adeno-associated Virus of a Single-polarity DNA Genome Is Capable of Transduction In Vivo","volume":"16","author":"Zhou","year":"2008","journal-title":"Mol. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/gt.2012.6","article-title":"Intracellular transport of recombinant adeno-associated virus vectors","volume":"19","author":"Nonnenmacher","year":"2012","journal-title":"Gene Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/4768","article-title":"\u03b1V\u03b25 integrin: A co-receptor for adeno-associated virus type 2 infection","volume":"5","author":"Summerford","year":"1999","journal-title":"Nat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1006\/viro.1999.0010","article-title":"Integrin alphaVbeta5 is not involved in adeno-associated virus type 2 (AAV2) infection","volume":"264","author":"Qiu","year":"1999","journal-title":"Virology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/sj.mt.6300053","article-title":"A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2 and 8","volume":"15","author":"Akache","year":"2007","journal-title":"Mol. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/mt.2011.4","article-title":"Enhancers of Adeno-associated Virus AAV2 Transduction via High Throughput siRNA Screening","volume":"19","author":"Wallen","year":"2011","journal-title":"Mol. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature16465","article-title":"An essential receptor for adeno-associated virus infection","volume":"530","author":"Pillay","year":"2016","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"14781","DOI":"10.1128\/JVI.79.23.14781-14792.2005","article-title":"Molecular Characterization of Adeno-Associated Viruses Infecting Children","volume":"79","author":"Chen","year":"2005","journal-title":"J. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ymthe.2019.11.005","article-title":"GPR108 Is a Highly Conserved AAV Entry Factor","volume":"28","author":"Dudek","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1128\/JVI.74.6.2777-2785.2000","article-title":"Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors","volume":"74","author":"Bartlett","year":"2000","journal-title":"J. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.chom.2011.10.014","article-title":"Adeno-Associated Virus 2 Infection Requires Endocytosis through the CLIC\/GEEC Pathway","volume":"10","author":"Nonnenmacher","year":"2011","journal-title":"Cell Host Microbe."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1128\/JVI.02520-14","article-title":"Syntaxin 5-Dependent Retrograde Transport to the trans -Golgi Network Is Required for Adeno-Associated Virus Transduction","volume":"89","author":"Nonnenmacher","year":"2015","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11040","DOI":"10.1128\/JVI.01056-06","article-title":"Adeno-Associated Virus Type 2 Capsids with Externalized VP1\/VP2 Trafficking Domains Are Generated prior to Passage through the Cytoplasm and Are Maintained until Uncoating Occurs in the Nucleus","volume":"80","author":"Sonntag","year":"2006","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1534-5807(01)00031-4","article-title":"A Viral Phospholipase A2 Is Required for Parvovirus Infectivity","volume":"1","author":"Szelei","year":"2001","journal-title":"Dev. Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1128\/JVI.02723-05","article-title":"Separate Basic Region Motifs within the Adeno-Associated Virus Capsid Proteins Are Essential for Infectivity and Assembly","volume":"80","author":"Grieger","year":"2006","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1099\/0022-1317-83-5-973","article-title":"The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity","volume":"83","author":"Girod","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.virol.2010.09.025","article-title":"Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles","volume":"409","author":"Stahnke","year":"2011","journal-title":"Virology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1128\/JVI.02309-08","article-title":"Enhancement of Adeno-Associated Virus Infection by Mobilizing Capsids into and Out of the Nucleolus","volume":"83","author":"Johnson","year":"2009","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1128\/JVI.78.6.3110-3122.2004","article-title":"Rapid Uncoating of Vector Genomes Is the Key to Efficient Liver Transduction with Pseudotyped Adeno-Associated Virus Vectors","volume":"78","author":"Thomas","year":"2004","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1038\/s41598-019-40071-1","article-title":"Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity","volume":"9","author":"Rossi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/jvi.33.2.739-748.1980","article-title":"Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells","volume":"33","author":"Cheung","year":"1980","journal-title":"J. Virol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"12849","DOI":"10.1073\/pnas.96.22.12849","article-title":"Adeno-associated virus (AAV) site-specific integration: Formation of AAV-AAVS1 junctions in an in vitro system","volume":"96","author":"Dyall","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.1128\/JVI.76.15.7554-7559.2002","article-title":"Kinetics and Frequency of Adeno-Associated Virus Site-Specific Integration into Human Chromosome 19 Monitored by Quantitative Real-Time PCR","volume":"76","author":"Huser","year":"2002","journal-title":"J. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1146\/annurev.genet.37.110801.143717","article-title":"Integration of Adeno-Associated Virus (AAV) and Recombinant AAV Vectors","volume":"38","author":"McCarty","year":"2004","journal-title":"Annu. Rev. Genet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1128\/jvi.71.2.1079-1088.1997","article-title":"The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection","volume":"71","author":"Pereira","year":"1997","journal-title":"J. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5777","DOI":"10.1128\/JVI.02651-06","article-title":"Purification of Host Cell Enzymes Involved in Adeno-Associated Virus DNA Replication","volume":"81","author":"Nash","year":"2007","journal-title":"J. Virol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1128\/JVI.01968-07","article-title":"Complete In Vitro Reconstitution of Adeno-Associated Virus DNA Replication Requires the Minichromosome Maintenance Complex Proteins","volume":"82","author":"Nash","year":"2008","journal-title":"J. Virol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1128\/JVI.72.4.2777-2787.1998","article-title":"Cellular Proteins Required for Adeno-Associated Virus DNA Replication in the Absence of Adenovirus Coinfection","volume":"72","author":"Ni","year":"1998","journal-title":"J. Virol."},{"key":"ref_66","unstructured":"Fields, B.N., Knipe, D.M., and Howley, P.M. (2007). Fields\u2019 Virology, Wolters Kluwer Health\/Lippincott Williams & Wilkins."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Im, D.-S., and Muzyczka, N. (1990). The AAV Origin Binding Protein Rep68 Is an ATP-Dependent Site-Specific Endonuclease with DNA Helicase Activity. Cell, 447\u2013457.","DOI":"10.1016\/0092-8674(90)90526-K"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.celrep.2018.04.026","article-title":"The Assembly-Activating Protein Promotes Stability and Interactions between AAV\u2019s Viral Proteins to Nucleate Capsid Assembly","volume":"23","author":"Maurer","year":"2018","journal-title":"Cell Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1128\/JVI.79.4.2528-2540.2005","article-title":"Mutational Analysis of Narrow Pores at the Fivefold Symmetry Axes of Adeno-Associated Virus Type 2 Capsids Reveals a Dual Role in Genome Packaging and Activation of Phospholipase A2 Activity","volume":"79","author":"Bleker","year":"2005","journal-title":"J. Virol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1093\/emboj\/20.12.3282","article-title":"DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids","volume":"20","author":"King","year":"2001","journal-title":"Embo J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1128\/JVI.77.1.776-781.2003","article-title":"Evidence for Packaging of rep-cap Sequences into Adeno-Associated Virus (AAV) Type 2 Capsids in the Absence of Inverted Terminal Repeats: A Model for Generation of rep-Positive AAV Particles","volume":"77","author":"Nony","year":"2003","journal-title":"J. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/jvi.40.1.241-247.1981","article-title":"Herpes Simplex Virus Types 1 and 2 Completely Help Adenovirus-Associated Virus Replication","volume":"40","author":"Buller","year":"1981","journal-title":"J. Virol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/jnci\/54.1.241","article-title":"Brief Communication: Potentiation of an Adenovirus-Associated Virus by Herpes Simplex Virus Type-2-Transformed Cells2","volume":"54","author":"Blacklow","year":"1975","journal-title":"Jnci J. Natl. Cancer Inst."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1006\/viro.1994.1535","article-title":"Human Herpesvirus 6 (HHV-6) Is a Helper Virus for Adeno-Associated Virus Type 2 (AAV-2) and the AAV-2 rep Gene Homologue in HHV-6 Can Mediate AAV-2 DNA Replication and Regulate Gene Expression","volume":"204","author":"Thomson","year":"1994","journal-title":"Virology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1089\/10430340260355347","article-title":"Insect Cells as a Factory to Produce Adeno-Associated Virus Type 2 Vectors","volume":"13","author":"Urabe","year":"2002","journal-title":"Hum. Gene Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1126\/science.1090284","article-title":"Three-Dimensional Structure of Herpes Simplex Virus from Cryo-Electron Tomography","volume":"302","author":"Desai","year":"2003","journal-title":"Science"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"d752","DOI":"10.2741\/taylor","article-title":"Herpes simplex virus","volume":"7","author":"Taylor","year":"2002","journal-title":"Front. Biosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1126\/science.288.5467.877","article-title":"Seeing the Herpesvirus Capsid at 8.5 A","volume":"288","author":"Zhou","year":"2000","journal-title":"Science"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"11216","DOI":"10.1021\/ja404008r","article-title":"Herpes Virus Genome, The Pressure Is On","volume":"135","author":"Bauer","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1073\/pnas.72.11.4243","article-title":"Anatomy of herpes simplex virus DNA: Evidence for four populations of molecules that differ in the relative orientations of their long and short components","volume":"72","author":"Hayward","year":"1975","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Mocarski, E.S., and Roizman, B. (1982). Structure and Role of the Herpes Simplex Virus DNA Termini in Inversion, Circularization and Generation of Virion DNA. Cell, 31.","DOI":"10.1016\/0092-8674(82)90408-1"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1128\/jvi.14.1.8-19.1974","article-title":"Regulation of herpesvirus macromolecular synthesis I. Cascade regulation of the synthesis of three groups of viral proteins","volume":"14","author":"Honess","year":"1974","journal-title":"J. Virol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0166-3542(95)00038-N","article-title":"Susceptibility to herpes labialis following multiple experimental exposures to ultraviolet radiation","volume":"28","author":"Spruance","year":"1995","journal-title":"Antivir. Res."},{"key":"ref_84","unstructured":"Smith, M.G., Lennette, E.H., and Reames, H.R. (1941). Isolation of the virus of herpes simplex and the demonstration of intranuclear inclusions in a case of acute encephalitis. Am. J. Pathol., 15."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/j.spid.2004.09.007","article-title":"Herpes simplex: Encephalitis children and adolescents","volume":"16","author":"Whitley","year":"2005","journal-title":"Semin. Pediatric Infect. Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.survophthal.2012.01.005","article-title":"Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update","volume":"57","author":"Farooq","year":"2012","journal-title":"Surv. Ophthalmol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1111\/j.1742-4658.2009.07402.x","article-title":"Viral entry mechanisms: Cellular and viral mediators of herpes simplex virus entry: Cellular and viral mediators of HSV entry","volume":"276","author":"Akhtar","year":"2009","journal-title":"Febs. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.coviro.2011.12.001","article-title":"Viral and cellular contributions to herpes simplex virus entry into the cell","volume":"2","author":"Menotti","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1128\/jvi.65.3.1090-1098.1991","article-title":"Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity","volume":"65","author":"Herold","year":"1991","journal-title":"J. Virol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1099\/0022-1317-75-6-1211","article-title":"Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B","volume":"75","author":"Herold","year":"1994","journal-title":"J. Gen. Virol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1126\/science.280.5369.1618","article-title":"Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor","volume":"280","author":"Geraghty","year":"1998","journal-title":"Science"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/viro.2000.0529","article-title":"Three Classes of Cell Surface Receptors for Alphaherpesvirus Entry","volume":"275","author":"Spear","year":"2000","journal-title":"Virology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.sbi.2019.12.004","article-title":"Herpesvirus membrane fusion \u2013 a team effort","volume":"62","author":"Vollmer","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1083\/jcb.136.5.1007","article-title":"Microtubule-mediated Transport of Incoming Herpes Simplex Virus 1 Capsids to the Nucleus","volume":"136","author":"Sodeik","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Radtke, K., Kieneke, D., Wolfstein, A., Michael, K., Steffen, W., Scholz, T., Karger, A., and Sodeik, B. (2010). Plus- and Minus-End Directed Microtubule Motors Bind Simultaneously to Herpes Simplex Virus Capsids Using Different Inner Tegument Structures. PloS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000991"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-2836(84)90427-3","article-title":"Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription","volume":"180","author":"Campbell","year":"1984","journal-title":"J. Mol. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Stern, S., and Herr, W. (1991). The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: Evidence for a homeo domain recognition subdomain. Genes Dev.","DOI":"10.1101\/gad.5.12b.2555"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/345783a0","article-title":"Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID","volume":"345","author":"Stringer","year":"1990","journal-title":"Nature"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1128\/JVI.74.4.1827-1839.2000","article-title":"Anterograde Transport of Herpes Simplex Virus Type 1 in Cultured, Dissociated Human and Rat Dorsal Root Ganglion Neurons","volume":"74","author":"Armati","year":"2000","journal-title":"J. Virol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Quinlan, M.P., Chen, L.B., and Knipe, D.M. (1984). The lntranuclear Location of a Herpes Simplex Virus DNA-Binding Protein Is Determined by the Status of Viral DNA Replication. Cell, 12.","DOI":"10.1016\/0092-8674(84)90035-7"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1128\/JVI.02476-06","article-title":"Live Covisualization of Competing Adeno-Associated Virus and Herpes Simplex Virus Type 1 DNA Replication: Molecular Mechanisms of Interaction","volume":"81","author":"Glauser","year":"2007","journal-title":"J. Virol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"a013011-a013011","DOI":"10.1101\/cshperspect.a013011","article-title":"Herpes Simplex Viruses: Mechanisms of DNA Replication","volume":"4","author":"Weller","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/j.1460-2075.1982.tb01261.x","article-title":"Localization of an origin of DNA replication within the TRS\/IRS repeated region of the herpes simplex virus type 1 genome","volume":"1","author":"Stow","year":"1982","journal-title":"Embo J."},{"key":"ref_104","first-page":"930","article-title":"Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis","volume":"5","author":"Weller","year":"1985","journal-title":"Mol. Cell. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/S0021-9258(18)52296-1","article-title":"The Herpes Simplex Virus 1 Origin Binding Protein: A DNA Helicase","volume":"266","author":"Bruckner","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Boehmer, P.E., Dodson, M.S., and Lehman, I.R. (1993). The Herpes Simplex Virus Type-1 Origin Binding Protein DNA Helicase Activity. J. Biol. Chem.","DOI":"10.1016\/S0021-9258(18)54063-1"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"8444","DOI":"10.1073\/pnas.90.18.8444","article-title":"Physical interaction between the herpes simplex virus 1 origin-binding protein and single-stranded DNA-binding protein ICP8","volume":"90","author":"Boehmer","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1128\/jvi.54.3.731-738.1985","article-title":"An immunoassay for the study of DNA-binding activities of herpes simplex virus protein ICP8","volume":"54","author":"Lee","year":"1985","journal-title":"J. Virol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1099\/0022-1317-75-10-2699","article-title":"The herpes simplex virus type 1 origin-binding protein interacts specifically with the viral UL8 protein","volume":"75","author":"McLean","year":"1994","journal-title":"J. Gen. Virol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/viro.1997.8953","article-title":"Interaction between the Herpes Simplex Virus Type 1 Origin-Binding and DNA Polymerase Accessory Proteins","volume":"241","author":"Monahan","year":"1998","journal-title":"Virology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"6585","DOI":"10.1093\/nar\/16.14.6585","article-title":"A DNA helicase induced by herpes simplex virus type 1","volume":"16","author":"Crute","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1073\/pnas.86.7.2186","article-title":"Herpes simplex virus 1 helicase-primase: A complex of three herpes-encoded gene products","volume":"86","author":"Crute","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/jvi.53.2.587-595.1985","article-title":"A noninverting genome of a viable herpes simplex virus 1: Presence of head-to-tail linkages in packaged genomes and requirements for circularization after infection","volume":"53","author":"Poffenberger","year":"1985","journal-title":"J. Virol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1073\/pnas.78.2.742","article-title":"Replication of herpes simplex virus DNA: Localization of replication recognition signals within defective virus genomes","volume":"78","author":"Vlazny","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jmb.2004.07.012","article-title":"Catalysis of Strand Exchange by the HSV-1 UL12 and ICP8 Proteins: Potent ICP8 Recombinase Activity is Revealed upon Resection of dsDNA Substrate by Nuclease","volume":"342","author":"Reuven","year":"2004","journal-title":"J. Mol. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Schumacher, A.J., Mohni, K.N., Kan, Y., Hendrickson, E.A., Stark, J.M., and Weller, S.K. (2012). The HSV-1 Exonuclease, UL12, Stimulates Recombination by a Single Strand Annealing Mechanism. PloS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002862"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1073\/pnas.1817642116","article-title":"Herpes simplex virus 1 ICP8 mutant lacking annealing activity is deficient for viral DNA replication","volume":"116","author":"Weerasooriya","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1006\/jmbi.1993.1406","article-title":"Structure of Herpes Simplex Virus Capsid Molecular Composition of the Pentons and the Triplexes","volume":"232","author":"Newcomb","year":"1993","journal-title":"J. Mol. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/(SICI)1099-1654(199707)7:2<107::AID-RMV191>3.0.CO;2-M","article-title":"Capsid assembly and DNA packaging in herpes simplex virus","volume":"7","author":"Homa","year":"1997","journal-title":"Rev. Med. Virol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1128\/JVI.73.5.4239-4250.1999","article-title":"Assembly of the Herpes Simplex Virus Procapsid from Purified Components and Identification of Small Complexes Containing the Major Capsid and Scaffolding Proteins","volume":"73","author":"Newcomb","year":"1999","journal-title":"J. Virol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"10923","DOI":"10.1128\/JVI.75.22.10923-10932.2001","article-title":"The UL6 Gene Product Forms the Portal for Entry of DNA into the Herpes Simplex Virus Capsid","volume":"75","author":"Newcomb","year":"2001","journal-title":"J. Virol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41586-019-1248-6","article-title":"Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome","volume":"570","author":"Liu","year":"2019","journal-title":"Nature"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/cmi.12044","article-title":"The way out: What we know and do not know about herpesvirus nuclear egress: Herpesvirus nuclear egress","volume":"15","author":"Mettenleiter","year":"2013","journal-title":"Cell. Microbiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1128\/JVI.00386-06","article-title":"The Egress of Herpesviruses from Cells: The Unanswered Questions","volume":"80","author":"Roizman","year":"2006","journal-title":"J. Virol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1128\/jvi.4.1.75-93.1969","article-title":"Herpes-Type Virus of the Frog Renal Adenocarcinoma","volume":"4","author":"Stackpole","year":"1969","journal-title":"J. Virol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1038\/s41467-018-05889-9","article-title":"ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity","volume":"9","author":"Arii","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1128\/JVI.75.12.5697-5702.2001","article-title":"Herpes Simplex Virus Nucleocapsids Mature to Progeny Virions by an Envelopment Deenvelopment Reenvelopment Pathway","volume":"75","author":"Skepper","year":"2001","journal-title":"J. Virol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nrmicro2559","article-title":"Herpesviruses remodel host membranes for virus egress","volume":"9","author":"Johnson","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1128\/JVI.79.2.1071-1083.2005","article-title":"Impairment of Nuclear Pores in Bovine Herpesvirus 1-Infected MDBK Cells","volume":"79","author":"Wild","year":"2005","journal-title":"J. Virol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"13047","DOI":"10.1128\/JVI.79.20.13047-13059.2005","article-title":"Herpes Simplex Virus 1 Envelopment Follows Two Diverse Pathways","volume":"79","author":"Leuzinger","year":"2005","journal-title":"J. Virol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1091\/mbc.01-06-0308","article-title":"Nuclear Pore Complex Is Able to Transport Macromolecules with Diameters of \u03f339 nm","volume":"13","author":"Pante","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1128\/jvi.65.5.2476-2483.1991","article-title":"A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication","volume":"65","author":"Weindler","year":"1991","journal-title":"J. Virol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1093\/nar\/gkg827","article-title":"ssDNA-dependent colocalization of adeno-associated virus Rep and herpes simplex virus ICP8 in nuclear replication domains","volume":"31","author":"Heilbronn","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"8871","DOI":"10.1128\/JVI.00725-10","article-title":"Identification of Rep-Associated Factors in Herpes Simplex Virus Type 1-Induced Adeno-Associated Virus Type 2 Replication Compartments","volume":"84","author":"Nicolas","year":"2010","journal-title":"J. Virol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1128\/JVI.02718-05","article-title":"Role of the Herpes Simplex Virus Helicase-Primase Complex during Adeno-Associated Virus DNA Replication","volume":"80","author":"Slanina","year":"2006","journal-title":"J. Virol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/jvi.66.2.1119-1128.1992","article-title":"Partial Purification of Adeno-Associated Virus Rep78, Rep52, and Rep4O and Their Biochemical Characterization","volume":"66","author":"Im","year":"1992","journal-title":"J. Virol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1128\/jvi.63.10.4450-4454.1989","article-title":"Expression from the adeno-associated virus p5 and p19 promoters is negatively regulated in trans by the rep protein","volume":"63","author":"Beaton","year":"1989","journal-title":"J. Virol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1128\/jvi.68.5.2947-2957.1994","article-title":"Analysis of Adeno-Associated Virus (AAV) Wild-Type and Mutant Rep Proteins for Their Abilities To Negatively Regulate AAV P5 and Plg mRNA Levels","volume":"68","author":"Kyostio","year":"1994","journal-title":"J. Virol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Alazard-Dany, N., Nicolas, A., Ploquin, A., Strasser, R., Greco, A., Epstein, A.L., Fraefel, C., and Salvetti, A. (2009). Definition of Herpes Simplex Virus Type 1 Helper Activities for Adeno-Associated Virus Early Replication Events. PloS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000340"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1002\/j.1460-2075.1987.tb02472.x","article-title":"A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1","volume":"6","author":"Everett","year":"1987","journal-title":"Embo J."},{"key":"ref_141","first-page":"957","article-title":"Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions","volume":"5","author":"Quinlan","year":"1985","journal-title":"Mol. Cell. Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1128\/JVI.76.2.841-850.2002","article-title":"Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 and Its Isolated RING Finger Domain Act as Ubiquitin E3 Ligases In Vitro","volume":"76","author":"Boutell","year":"2002","journal-title":"J. Virol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1073\/pnas.022531599","article-title":"Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes","volume":"99","author":"Hagglund","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"10977","DOI":"10.1128\/JVI.78.20.10977-10986.2004","article-title":"Herpes Simplex Virus Type 1 ICP0 Protein Mediates Activation of Adeno-Associated Virus Type 2 rep Gene Expression from a Latent Integrated Form","volume":"78","author":"Geoffroy","year":"2004","journal-title":"J. Virol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1128\/JVI.80.7.3650-3654.2006","article-title":"Impact of the Interaction between Herpes Simplex Virus Type 1 Regulatory Protein ICP0 and Ubiquitin-Specific Protease USP7 on Activation of Adeno-Associated Virus Type 2 rep Gene Expression","volume":"80","author":"Geoffroy","year":"2006","journal-title":"J. Virol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1016\/S0021-9258(18)50411-7","article-title":"Adeno-associated Virus DNA Replication Complexes in Herpes Simplex Virus or Adenovirus-infected Cells","volume":"254","author":"Handa","year":"1979","journal-title":"J. Biol. Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1021\/bi00696a015","article-title":"Mode of inhibition of Herpes simplex virus DNA polymerase by phosphonoacetate","volume":"14","author":"Mao","year":"1975","journal-title":"Biochemistry"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"10250","DOI":"10.1128\/JVI.75.21.10250-10258.2001","article-title":"Rep-Dependent Initiation of Adeno-Associated Virus Type 2 DNA Replication by a Herpes Simplex Virus Type 1 Replication Complex in a Reconstituted System","volume":"75","author":"Ward","year":"2001","journal-title":"J. Virol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"7425","DOI":"10.1128\/JVI.77.13.7425-7433.2003","article-title":"The Herpes Simplex Virus Type 1 Alkaline Nuclease and Single-Stranded DNA Binding Protein Mediate Strand Exchange In Vitro","volume":"77","author":"Reuven","year":"2003","journal-title":"J. Virol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1099\/vir.0.000034","article-title":"Definition of herpes simplex virus helper functions for the replication of adeno-associated virus type 5","volume":"96","author":"Stutika","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0042-6822(84)90271-X","article-title":"Characterization of the DNA of a defective human parvovirus isolated from a genital site","volume":"134","year":"1984","journal-title":"Virology"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.1128\/JVI.78.12.6381-6388.2004","article-title":"Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues","volume":"78","author":"Gao","year":"2004","journal-title":"J. Virol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"9976","DOI":"10.1128\/JVI.00630-07","article-title":"cis Effects in Adeno-Associated Virus Type 2 Replication","volume":"81","author":"Ward","year":"2007","journal-title":"J. Virol."},{"key":"ref_154","first-page":"1","article-title":"Adeno-associated virus biology","volume":"807","author":"Weitzman","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1073\/pnas.74.10.4508","article-title":"Helper factor(s) for growth of adeno-associated virus in cells transformed by adenovirus 12","volume":"74","author":"Handa","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Khanal, S., Ghimire, P., and Dhamoon, A.S. (2018). The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly. Biomedicines, 6.","DOI":"10.20944\/preprints201801.0267.v1"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Doerfler, W., and B\u00f6hm, P. (2003). Adenoviruses: Model. and Vectors in Virus-Host Interactions, Springer.","DOI":"10.1007\/978-3-662-05597-7"},{"key":"ref_158","first-page":"53","article-title":"The mechanism of adenovirus DNA replication and the characterization of replication proteins","volume":"109","author":"Sussenbach","year":"1984","journal-title":"Curr Top. Microbiol. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"a013003","DOI":"10.1101\/cshperspect.a013003","article-title":"Adenovirus DNA replication","volume":"5","author":"Hoeben","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1101\/gad.4.1.137","article-title":"General repression of enhanson activity by the adenovirus-2 E1A proteins","volume":"4","author":"Fromental","year":"1990","journal-title":"Genes Dev."},{"key":"ref_161","first-page":"425","article-title":"Adenovirus e1a proteins and transformation (review)","volume":"5","author":"Bayley","year":"1994","journal-title":"Int. J. Oncol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0955-0674(99)00085-X","article-title":"A-kinase anchoring proteins: Protein kinase A and beyond","volume":"12","author":"Edwards","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_163","first-page":"4852","article-title":"Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A","volume":"13","author":"Hagiwara","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/365855a0","article-title":"Phosphorylated CREB binds specifically to the nuclear protein CBP","volume":"365","author":"Chrivia","year":"1993","journal-title":"Nature"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"40554","DOI":"10.1074\/jbc.M004626200","article-title":"E1A12S-mediated activation of the adenovirus type 12 E2 promoter depends on the histone acetyltransferase activity of p300\/CBP","volume":"275","author":"Fax","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"8911","DOI":"10.1074\/jbc.275.12.8911","article-title":"cAMP-independent activation of the adenovirus type 12 E2 promoter correlates with the recruitment of CREB-1\/ATF-1, E1A(12S), and CBP to the E2-CRE","volume":"275","author":"Fax","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1128\/MCB.18.2.967","article-title":"A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos","volume":"18","author":"Ahn","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"ref_168","unstructured":"Van der Vliet PC, H.R. (2006). Adenovirus. DNA Replication and Human Disease, Cold Spring Harbor Laboratory Press."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1101\/gad.10.4.461","article-title":"The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein","volume":"10","author":"Han","year":"1996","journal-title":"Genes Dev."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.virusres.2009.10.008","article-title":"Adenovirus E1A and E1B-19K proteins protect human hepatoma cells from transforming growth factor beta1-induced apoptosis","volume":"147","author":"Tarakanova","year":"2010","journal-title":"Virus Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1128\/JVI.76.9.4547-4558.2002","article-title":"Bak and Bax function to limit adenovirus replication through apoptosis induction","volume":"76","author":"Cuconati","year":"2002","journal-title":"J. Virol."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Piya, S., White, E.J., Klein, S.R., Jiang, H., McDonnell, T.J., Gomez-Manzano, C., and Fueyo, J. (2011). The E1B19K oncoprotein complexes with Beclin 1 to regulate autophagy in adenovirus-infected cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0029467"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1038\/sj.onc.1204861","article-title":"Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus","volume":"20","author":"White","year":"2001","journal-title":"Oncogene"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1128\/jvi.71.5.3788-3798.1997","article-title":"Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells","volume":"71","author":"Querido","year":"1997","journal-title":"J. Virol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/sj.onc.1201540","article-title":"The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells","volume":"16","author":"Steegenga","year":"1998","journal-title":"Oncogene"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1128\/JVI.02417-08","article-title":"Adenovirus E1B 55-kilodalton protein: Multiple roles in viral infection and cell transformation","volume":"83","author":"Blackford","year":"2009","journal-title":"J. Virol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1002\/1873-3468.13694","article-title":"The biology of the adenovirus E1B 55K protein","volume":"593","author":"Hidalgo","year":"2019","journal-title":"Febs. Lett."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2741\/1604","article-title":"Functions of the adenovirus E4 proteins and their impact on viral vectors","volume":"10","author":"Weitzman","year":"2005","journal-title":"Front. Biosci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1128\/jvi.61.12.3759-3768.1987","article-title":"Adenovirus early region 4 is required for efficient virus particle assembly","volume":"61","author":"Falgout","year":"1987","journal-title":"J. Virol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/jvi.63.2.631-638.1989","article-title":"Redundant control of adenovirus late gene expression by early region 4","volume":"63","author":"Bridge","year":"1989","journal-title":"J. Virol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1128\/jvi.49.3.692-700.1984","article-title":"Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells","volume":"49","author":"Sarnow","year":"1984","journal-title":"J. Virol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1073\/pnas.91.1.153","article-title":"Deletion of the E4 region of the genome produces adenovirus DNA concatemers","volume":"91","author":"Weiden","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nature00863","article-title":"Adenovirus oncoproteins inactivate the Mre11\u2013Rad50\u2013NBS1 DNA repair complex","volume":"418","author":"Stracker","year":"2002","journal-title":"Nature"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.virusres.2015.06.018","article-title":"Adenovirus VA RNA: An essential pro-viral non-coding RNA","volume":"212","author":"Vachon","year":"2016","journal-title":"Virus Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1128\/jvi.65.11.5657-5662.1991","article-title":"Adenovirus virus-associated RNA and translation control","volume":"65","author":"Mathews","year":"1991","journal-title":"J. Virol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0092-8674(86)90383-1","article-title":"Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase","volume":"45","author":"Kitajewski","year":"1986","journal-title":"Cell"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0092-8674(86)90460-5","article-title":"A mechanism for the control of protein synthesis by adenovirus VA RNAI","volume":"44","author":"Mariano","year":"1986","journal-title":"Cell"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1128\/jvi.70.7.4495-4501.1996","article-title":"In vitro replication of adeno-associated virus DNA: Enhancement by extracts from adenovirus-infected HeLa cells","volume":"70","author":"Ward","year":"1996","journal-title":"J Virol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1128\/JVI.02312-06","article-title":"Positive and negative effects of adenovirus type 5 helper functions on adeno-associated virus type 5 (AAV5) protein accumulation govern AAV5 virus production","volume":"81","author":"Nayak","year":"2007","journal-title":"J. Virol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1128\/jvi.41.3.868-876.1982","article-title":"Effect of deletions in adenovirus early region 1 genes upon replication of adeno-associated virus","volume":"41","author":"Laughlin","year":"1982","journal-title":"J. Virol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1128\/jvi.51.3.611-619.1984","article-title":"Genetic analysis of adeno-associated virus: Properties of deletion mutants constructed in vitro and evidence for an adeno-associated virus replication function","volume":"51","author":"Tratschin","year":"1984","journal-title":"J. Virol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1128\/jvi.63.8.3479-3488.1989","article-title":"Adeno-associated virus P5 promoter contains an adenovirus E1A-inducible element and a binding site for the major late transcription factor","volume":"63","author":"Chang","year":"1989","journal-title":"J. Virol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1128\/JVI.72.3.2224-2232.1998","article-title":"Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus","volume":"72","author":"Xiao","year":"1998","journal-title":"J. Virol."},{"key":"ref_194","first-page":"2072","article-title":"A human parvovirus, adeno-associated virus, as a eucaryotic vector: Transient expression and encapsidation of the procaryotic gene for chloramphenicol acetyltransferase","volume":"4","author":"Tratschin","year":"1984","journal-title":"Mol. Cell Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1128\/jvi.51.2.404-410.1984","article-title":"Requirement for either early region 1a or early region 1b adenovirus gene products in the helper effect for adeno-associated virus","volume":"51","author":"Richardson","year":"1984","journal-title":"J. Virol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0092-8674(91)90189-6","article-title":"Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein","volume":"67","author":"Shi","year":"1991","journal-title":"Cell"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1128\/jvi.62.1.206-210.1988","article-title":"Adenovirus E1B 55-Mr polypeptide facilitates timely cytoplasmic accumulation of adeno-associated virus mRNAs","volume":"62","author":"Samulski","year":"1988","journal-title":"J. Virol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1128\/jvi.70.1.520-532.1996","article-title":"Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis","volume":"70","author":"Fisher","year":"1996","journal-title":"J. Virol."},{"key":"ref_199","first-page":"470","article-title":"The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs","volume":"6","author":"Pilder","year":"1986","journal-title":"Mol. Cell Biol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1128\/JVI.72.1.420-427.1998","article-title":"Role of the adenovirus DNA-binding protein in in vitro adeno-associated virus DNA replication","volume":"72","author":"Ward","year":"1998","journal-title":"J. Virol."},{"key":"ref_201","first-page":"938","article-title":"Adeno-associated virus vectors can be efficiently produced without helper virus","volume":"5","author":"Matsushita","year":"1998","journal-title":"Gene"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/JVI.78.1.441-453.2004","article-title":"The Rep Protein of Adeno-Associated Virus Type 2 Interacts with Single-Stranded DNA-Binding Proteins That Enhance Viral Replication","volume":"78","author":"Stracker","year":"2004","journal-title":"J. Virol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0042-6822(92)90213-9","article-title":"Adenovirus containing a deletion of the early region 2A gene allows growth of adeno-associated virus with decreased efficiency","volume":"191","author":"Carter","year":"1992","journal-title":"Virology"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1128\/jvi.64.5.2103-2109.1990","article-title":"The adenovirus DNA-binding protein stimulates the rate of transcription directed by adenovirus and adeno-associated virus promoters","volume":"64","author":"Chang","year":"1990","journal-title":"J. Virol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1128\/jvi.70.5.3227-3234.1996","article-title":"Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors","volume":"70","author":"Ferrari","year":"1996","journal-title":"J. Virol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"12936","DOI":"10.1128\/JVI.01523-07","article-title":"The Mre11\/Rad50\/Nbs1 complex limits adeno-associated virus transduction and replication","volume":"81","author":"Schwartz","year":"2007","journal-title":"J. Virol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1128\/JVI.01990-14","article-title":"Insight into the mechanism of inhibition of adeno-associated virus by the Mre11\/Rad50\/Nbs1 complex","volume":"89","author":"Lentz","year":"2015","journal-title":"J. Virol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/mthe.1999.0010","article-title":"Improved adeno-associated virus vector production with transfection of a single helper adenovirus gene, E4orf6","volume":"1","author":"Allen","year":"2000","journal-title":"Mol. Ther. 1"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.1128\/JVI.01132-07","article-title":"Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA","volume":"81","author":"Nayak","year":"2007","journal-title":"J. Virol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0042-6822(89)90272-9","article-title":"Efficient synthesis of adeno-associated virus structural proteins requires both adenovirus DNA binding protein and VA I RNA","volume":"168","author":"Janik","year":"1989","journal-title":"Virology"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1099\/vir.0.79940-0","article-title":"The adenovirus E1A and E1B19K genes provide a helper function for transfection-based adeno-associated virus vector production","volume":"85","author":"Matsushita","year":"2004","journal-title":"J. Gen. Virol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0042-6822(80)90354-2","article-title":"Adenovirus early region 1b gene function required for rescue of latent adeno-associated virus","volume":"104","author":"Ostrove","year":"1980","journal-title":"Virology"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1128\/jvi.70.3.1845-1854.1996","article-title":"Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers","volume":"70","author":"Weitzman","year":"1996","journal-title":"J. Virol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/351078a0","article-title":"Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6","volume":"351","author":"Thomson","year":"1991","journal-title":"Nature"},{"key":"ref_215","first-page":"2278","article-title":"Adeno-associated virus inhibits human papillomavirus type 16: A viral interaction implicated in cervical cancer","volume":"54","author":"Hermonat","year":"1994","journal-title":"Cancer Res."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/viro.2001.0968","article-title":"Altered biology of adeno-associated virus type 2 and human papillomavirus during dual infection of natural host tissue","volume":"287","author":"Meyers","year":"2001","journal-title":"Virology"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/exmp.2000.2347","article-title":"Adeno-associated virus is associated with a lower risk of high-grade cervical neoplasia","volume":"70","author":"Coker","year":"2001","journal-title":"Exp. Mol. Pathol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ijc.1496","article-title":"Adeno-associated virus seropositivity and HPV-induced cervical cancer in Spain and Colombia","volume":"94","author":"Smith","year":"2001","journal-title":"Int. J. Cancer"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1099\/0022-1317-78-6-1441","article-title":"Interaction of human papillomavirus type 16 and adeno-associated virus type 2 co-infecting human cervical epithelium","volume":"78","author":"Walz","year":"1997","journal-title":"J. Gen. Virol."},{"key":"ref_220","first-page":"418","article-title":"HPV-16 E1, E2 and E6 each complement the Ad5 helper gene set, increasing rAAV2 and wt AAV2 production","volume":"19","author":"Cao","year":"2012","journal-title":"Gene"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000495137","article-title":"The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication","volume":"61","author":"Cao","year":"2018","journal-title":"Intervirology"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.virol.2005.08.039","article-title":"Multiple human papillomavirus genes affect the adeno-associated virus life cycle","volume":"344","author":"You","year":"2006","journal-title":"Virology"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.virusres.2016.11.002","article-title":"The interaction between human papillomavirus and other viruses","volume":"231","author":"Guidry","year":"2017","journal-title":"Virus Res."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.virol.2010.03.001","article-title":"HPV E1 up-regulates replication-related biochemistries of AAV Rep78","volume":"402","author":"Bandyopadhyay","year":"2010","journal-title":"Virology"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1021\/bi701579v","article-title":"AAV-2 Rep78 and HPV-16 E1 interact in vitro, modulating their ATPase activity","volume":"47","author":"Bandyopadhyay","year":"2008","journal-title":"Biochemistry"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.omtm.2018.09.005","article-title":"Development of a Novel Recombinant Adeno-Associated Virus Production System Using Human Bocavirus 1 Helper Genes","volume":"11","author":"Wang","year":"2018","journal-title":"Mol. Methods Clin. Dev."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.omtm.2019.01.003","article-title":"Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses","volume":"12","author":"Fakhiri","year":"2019","journal-title":"Mol. Methods Clin. Dev."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0042-6822(88)90620-4","article-title":"Adeno-associated viruses inhibit SV40 DNA amplification and replication of herpes simplex virus in SV40-transformed hamster cells","volume":"164","year":"1988","journal-title":"Virology"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1128\/JVI.01503-09","article-title":"Inhibition of Herpes Simplex Virus Type 1 Replication by Adeno-Associated Virus Rep Proteins Depends on Their Combined DNA-Binding and ATPase\/Helicase Activities","volume":"84","author":"Glauser","year":"2010","journal-title":"J. Virol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/jvi.64.6.3012-3018.1990","article-title":"The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification","volume":"64","author":"Heilbronn","year":"1990","journal-title":"J. Virol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"11150","DOI":"10.1128\/JVI.01370-15","article-title":"Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome","volume":"89","author":"Seyffert","year":"2015","journal-title":"J. Virol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"e00357-00317","DOI":"10.1128\/JVI.00357-17","article-title":"Cell Cycle-Dependent Expression of Adeno-Associated Virus 2 (AAV2) Rep in Coinfections with Herpes Simplex Virus 1 (HSV-1) Gives Rise to a Mosaic of Cells Replicating either AAV2 or HSV-1","volume":"91","author":"Franzoso","year":"2017","journal-title":"J. Virol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/jvi.7.6.783-791.1971","article-title":"Deoxyribonucleic Acid Synthesis in Synchronized Mammalian KB Cells Infected with Herpes Simplex Virus","volume":"7","author":"Cohen","year":"1971","journal-title":"J. Virol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1128\/JVI.73.10.8245-8255.1999","article-title":"Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0","volume":"73","author":"Hobbs","year":"1999","journal-title":"J. Virol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"9456","DOI":"10.1128\/JVI.73.11.9456-9467.1999","article-title":"Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Inhibits Progression of Cells through Mitosis and from G1 into S Phase of the Cell Cycle","volume":"73","author":"Lomonte","year":"1999","journal-title":"J. Virol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1006\/viro.1999.0146","article-title":"Herpes Simplex Virus Infection Blocks Events in the G1 Phase of the Cell Cycle","volume":"267","author":"Song","year":"2000","journal-title":"Virology"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/JVI.05694-11","article-title":"Adeno-Associated Virus Type 2 Modulates the Host DNA Damage Response Induced by Herpes Simplex Virus 1 during Coinfection","volume":"86","author":"Vogel","year":"2012","journal-title":"J. Virol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1128\/JVI.79.1.28-38.2005","article-title":"Identification of an adeno-associated virus Rep protein binding site in the adenovirus E2a promoter","volume":"79","author":"Casper","year":"2005","journal-title":"J. Virol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1128\/JVI.00183-06","article-title":"Adeno-associated virus rep protein-mediated inhibition of transcription of the adenovirus major late promoter in vitro","volume":"80","author":"Needham","year":"2006","journal-title":"J. Virol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"7807","DOI":"10.1128\/JVI.00198-06","article-title":"Effects of adeno-associated virus on adenovirus replication and gene expression during coinfection","volume":"80","author":"Timpe","year":"2006","journal-title":"J. Virol."},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Seyffert, M., Glauser, D.L., Schraner, E.M., de Oliveira, A.-P., Mansilla-Soto, J., Vogt, B., B\u00fcning, H., Linden, R.M., Ackermann, M., and Fraefel, C. (2017). Novel Mutant AAV2 Rep Proteins Support AAV2 Replication without Blocking HSV-1 Helpervirus Replication. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170908"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/emboj\/cdg153","article-title":"PKA\/PrKX activity is a modulator of AAV\/adenovirus interaction","volume":"22","author":"Chiorini","year":"2003","journal-title":"Embo J."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1128\/JVI.03120-15","article-title":"A Regulatory Element Near the 3\u2019 End of the Adeno-Associated Virus rep Gene Inhibits Adenovirus Replication in cis by Means of p40 Promoter-Associated Short Transcripts","volume":"90","author":"Weger","year":"2016","journal-title":"J. Virol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1006\/gyno.1997.4789","article-title":"Adeno-associated virus Rep78 inhibits oncogenic transformation of primary human keratinocytes by a human papillomavirus type 16-ras chimeric","volume":"66","author":"Hermonat","year":"1997","journal-title":"Gynecol. Oncol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"31619","DOI":"10.1074\/jbc.274.44.31619","article-title":"Binding of the human papillomavirus type 16 p97 promoter by the adeno-associated virus Rep78 major regulatory protein correlates with inhibition","volume":"274","author":"Zhan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/viro.2001.1256","article-title":"Adenoassociated virus type 2-induced inhibition of the human papillomavirus type 18 promoter in transgenic mice","volume":"293","author":"Walz","year":"2002","journal-title":"Virology"},{"key":"ref_247","first-page":"373","article-title":"Detection of physical status of human papillomavirus 16 in cervical cancer tissue and SiHa cell line by multiplex real-time polymerase chain reaction","volume":"25","author":"Zheng","year":"2006","journal-title":"Ai Zheng"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1128\/jvi.65.1.396-404.1991","article-title":"Adeno-associated virus Rep protein inhibits human immunodeficiency virus type 1 production in human cells","volume":"65","author":"Antoni","year":"1991","journal-title":"J. Virol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.coviro.2016.08.003","article-title":"In vivo tissue-tropism of adeno-associated viral vectors","volume":"21","author":"Srivastava","year":"2016","journal-title":"Curr. Opin. Virol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1073\/pnas.87.6.2211","article-title":"Site-specific integration by adeno-associated virus","volume":"87","author":"Kotin","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"7951","DOI":"10.1128\/jvi.71.10.7951-7959.1997","article-title":"Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome","volume":"71","author":"Surosky","year":"1997","journal-title":"J. Virol."},{"key":"ref_252","first-page":"1248","article-title":"Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis","volume":"8","author":"McCarty","year":"2001","journal-title":"Gene"},{"key":"ref_253","first-page":"2745","article-title":"Novel tools for production and purification of recombinant adenoassociated virus vectors","volume":"9","author":"Grimm","year":"1998","journal-title":"Hum. Gene"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0378-1119(99)00347-9","article-title":"A helper virus-free packaging system for recombinant adeno-associated virus vectors","volume":"238","author":"Collaco","year":"1999","journal-title":"Gene"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/mt.2015.187","article-title":"Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector","volume":"24","author":"Grieger","year":"2016","journal-title":"Mol. Ther."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/hgtb.2013.046","article-title":"Generation and characterization of adeno-associated virus producer cell lines for research and preclinical vector production","volume":"24","author":"Martin","year":"2013","journal-title":"Hum. Gene Methods"},{"key":"ref_257","first-page":"2353","article-title":"High-titer adeno-associated viral vectors from a Rep\/Cap cell line and hybrid shuttle virus","volume":"9","author":"Gao","year":"1998","journal-title":"Hum. Gene"},{"key":"ref_258","first-page":"986","article-title":"High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap","volume":"6","author":"Conway","year":"1999","journal-title":"Gene"},{"key":"ref_259","first-page":"796","article-title":"Large-scale adeno-associated viral vector production using a herpesvirus-based system enables manufacturing for clinical studies","volume":"20","author":"Clement","year":"2009","journal-title":"Hum. Gene"},{"key":"ref_260","first-page":"861","article-title":"Scalable recombinant adeno-associated virus production using recombinant herpes simplex virus type 1 coinfection of suspension-adapted mammalian cells","volume":"20","author":"Thomas","year":"2009","journal-title":"Hum. Gene"},{"key":"ref_261","first-page":"1239","article-title":"Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing alpha1-antitrypsin: Interim results","volume":"22","author":"Flotte","year":"2011","journal-title":"Hum. Gene"},{"key":"ref_262","first-page":"807","article-title":"Producing recombinant adeno-associated virus in foster cells: Overcoming production limitations using a baculovirus-insect cell expression strategy","volume":"20","author":"Virag","year":"2009","journal-title":"Hum. Gene"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/mt.2009.128","article-title":"A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells","volume":"17","author":"Smith","year":"2009","journal-title":"Mol. Ther."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.ymthe.2005.08.018","article-title":"Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system","volume":"12","author":"Kohlbrenner","year":"2005","journal-title":"Mol. Ther."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Goncalves, M.A., Holkers, M., van Nierop, G.P., Wieringa, R., Pau, M.G., and de Vries, A.A. (2008). Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003084"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1128\/JVI.79.5.3146-3162.2005","article-title":"Transfer of the full-length dystrophin-coding sequence into muscle cells by a dual high-capacity hybrid viral vector with site-specific integration ability","volume":"79","author":"Goncalves","year":"2005","journal-title":"J. Virol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"7163","DOI":"10.1128\/JVI.76.14.7163-7173.2002","article-title":"Herpes simplex virus type 1\/adeno-associated virus hybrid vectors mediate site-specific integration at the adeno-associated virus preintegration site, AAVS1, on human chromosome 19","volume":"76","author":"Heister","year":"2002","journal-title":"J. Virol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ymthe.2004.07.003","article-title":"Site-specific integration of functional transgenes into the human genome by adeno\/AAV hybrid vectors","volume":"10","author":"Recchia","year":"2004","journal-title":"Mol. Ther."},{"key":"ref_269","first-page":"1078","article-title":"Integration of active human beta-galactosidase gene (100 kb) into genome using HSV\/AAV amplicon vector","volume":"14","author":"Oehmig","year":"2007","journal-title":"Gene"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1128\/JVI.78.1.389-398.2004","article-title":"Spatial and Temporal Organization of Adeno-Associated Virus DNA Replication in Live Cells","volume":"78","author":"Fraefel","year":"2004","journal-title":"J. Virol."},{"key":"ref_271","first-page":"681","article-title":"Alipogene tiparvovec, an adeno-associated virus encoding the Ser(447)X variant of the human lipoprotein lipase gene for the treatment of patients with lipoprotein lipase deficiency","volume":"11","author":"Burnett","year":"2009","journal-title":"Curr. Opin. Mol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd.2018.158","article-title":"Gene therapy for neurological disorders: Progress and prospects","volume":"17","author":"Deverman","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.hlc.2018.03.005","article-title":"Adeno-Associated Virus Gene Therapy: Translational Progress and Future Prospects in the Treatment of Heart Failure","volume":"27","author":"Bernardo","year":"2018","journal-title":"Heart Lung Circ."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1089\/hum.2017.172","article-title":"Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution","volume":"28","author":"Grimm","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/156652311796150354","article-title":"Immune responses to AAV in clinical trials","volume":"11","author":"Mingozzi","year":"2011","journal-title":"Curr. Gene"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fimmu.2014.00082","article-title":"Immune Responses to AAV-Vectors, the Glybera Example from Bench to Bedside","volume":"5","author":"Ferreira","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.89.15.7257","article-title":"Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector","volume":"89","author":"Walsh","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1128\/jvi.71.4.3299-3306.1997","article-title":"Adeno-associated virus Rep78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome","volume":"71","author":"Balague","year":"1997","journal-title":"J. Virol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1128\/jvi.69.4.2038-2046.1995","article-title":"Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein","volume":"69","author":"Urcelay","year":"1995","journal-title":"J. Virol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1073\/pnas.91.13.5808","article-title":"Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA","volume":"91","author":"Weitzman","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_281","first-page":"872","article-title":"Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors","volume":"17","author":"Zeltner","year":"2010","journal-title":"Gene"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/12\/6\/662\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:40:46Z","timestamp":1760175646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/12\/6\/662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":281,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["v12060662"],"URL":"https:\/\/doi.org\/10.3390\/v12060662","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}