{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:28:01Z","timestamp":1791599281883,"version":"4.3.4"},"reference-count":66,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR18-CE11-0001"],"award-info":[{"award-number":["ANR18-CE11-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R\u00e9gion Auvergne Rh\u00f4ne-Alpes","award":["Cov-Mime"],"award-info":[{"award-number":["Cov-Mime"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Many geometric forms are found in nature, some of them adhering to mathematical laws or amazing aesthetic rules. One of the best-known examples in microbiology is the icosahedral shape of certain viruses with 20 triangular facets and 12 edges. What is less known, however, is that a complementary object displaying 12 faces and 20 edges called a \u2018dodecahedron\u2019 can be produced in huge amounts during certain adenovirus replication cycles. The decahedron was first described more than 50 years ago in the human adenovirus (HAdV3) viral cycle. Later on, the expression of this recombinant scaffold, combined with improvements in cryo-electron microscopy, made it possible to decipher the structural determinants underlying their architecture. Recently, this particle, which mimics viral entry, was used to fish the long elusive adenovirus receptor, desmoglein-2, which serves as a cellular docking for some adenovirus serotypes. This breakthrough enabled the understanding of the physiological role played by the dodecahedral particles, showing that icosahedral and dodecahedral particles live more than a simple platonic story. All these points are developed in this review, and the potential use of the dodecahedron in therapeutic development is discussed.<\/jats:p>","DOI":"10.3390\/v12070718","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T06:51:20Z","timestamp":1593759080000},"page":"718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The Adenovirus Dodecahedron: Beyond the Platonic Story"],"prefix":"10.3390","volume":"12","author":[{"given":"Sol\u00e8ne","family":"Besson","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique, Universit\u00e9 Grenoble Alpes, Commissariat En\u00e9rgies Alternatives, Institut de Biologie Structurale, 41 rue des Martyrs, 38042 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Vragniau","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Universit\u00e9 Grenoble Alpes, Commissariat En\u00e9rgies Alternatives, Institut de Biologie Structurale, 41 rue des Martyrs, 38042 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, Universit\u00e9 Grenoble Alpes, Institut National Polytechnique Grenoble, Technique de l\u2019ing\u00e9nierie M\u00e9dicale et de la Complexit\u00e9, TIMC-IMAG B\u00e2t Jean Roget Facult\u00e9 de M\u00e9decine et Pharmacie, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Vassal-Stermann","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Universit\u00e9 Grenoble Alpes, Commissariat En\u00e9rgies Alternatives, Institut de Biologie Structurale, 41 rue des Martyrs, 38042 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Claire","family":"Dagher","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Universit\u00e9 Grenoble Alpes, Commissariat En\u00e9rgies Alternatives, Institut de Biologie Structurale, 41 rue des Martyrs, 38042 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-3367","authenticated-orcid":false,"given":"Pascal","family":"Fender","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Universit\u00e9 Grenoble Alpes, Commissariat En\u00e9rgies Alternatives, Institut de Biologie Structurale, 41 rue des Martyrs, 38042 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/CMR.00116-13","article-title":"Adenovirus infections in immunocompetent and immunocompromised patients","volume":"27","author":"Lion","year":"2014","journal-title":"Clin. 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