{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:59:30Z","timestamp":1790517570590,"version":"4.1.0"},"reference-count":154,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Group-B enteroviruses (EV-B) are ubiquitous naked single-stranded positive RNA viral pathogens that are responsible for common acute or persistent human infections. Their genome is composed in the 5\u2032 end by a non-coding region, which is crucial for the initiation of the viral replication and translation processes. RNA domain-I secondary structures can interact with viral or cellular proteins to form viral ribonucleoprotein (RNP) complexes regulating viral genomic replication, whereas RNA domains-II to -VII (internal ribosome entry site, IRES) are known to interact with cellular ribosomal subunits to initiate the viral translation process. Natural 5\u2032 terminally deleted viral forms lacking some genomic RNA domain-I secondary structures have been described in EV-B induced murine or human infections. Recent in vitro studies have evidenced that the loss of some viral RNP complexes in the RNA domain-I can modulate the viral replication and infectivity levels in EV-B infections. Moreover, the disruption of secondary structures of RNA domain-I could impair viral RNA sensing by RIG-I (Retinoic acid inducible gene I) or MDA5 (melanoma differentiation-associated protein 5) receptors, a way to overcome antiviral innate immune response. Overall, natural 5\u2032 terminally deleted viral genomes resulting in the loss of various structures in the RNA domain-I could be major key players of host\u2013cell interactions driving the development of acute or persistent EV-B infections.<\/jats:p>","DOI":"10.3390\/v12090919","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T21:28:06Z","timestamp":1598218086000},"page":"919","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Structures and Functions of Viral 5\u2032 Non-Coding Genomic RNA Domain-I in Group-B Enterovirus Infections"],"prefix":"10.3390","volume":"12","author":[{"given":"Marie","family":"Glenet","sequence":"first","affiliation":[{"name":"EA-4684 CardioVir, Faculty of Medicine, University of Reims Champagne-Ardenne (URCA), 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Heng","sequence":"additional","affiliation":[{"name":"EA-4684 CardioVir, Faculty of Medicine, University of Reims Champagne-Ardenne (URCA), 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2443-1684","authenticated-orcid":false,"given":"Domitille","family":"Callon","sequence":"additional","affiliation":[{"name":"EA-4684 CardioVir, Faculty of Medicine, University of Reims Champagne-Ardenne (URCA), 51097 Reims, France"},{"name":"Laboratoire de Biopathologie, Centre Hospitalier Universitaire Reims, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Lebreil","sequence":"additional","affiliation":[{"name":"EA-4684 CardioVir, Faculty of Medicine, University of Reims Champagne-Ardenne (URCA), 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7250-9656","authenticated-orcid":false,"given":"Paul-Antoine","family":"Gretteau","sequence":"additional","affiliation":[{"name":"EA-4684 CardioVir, Faculty of Medicine, University of Reims Champagne-Ardenne (URCA), 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"EA-4684 CardioVir, Faculty of Medicine, University of Reims Champagne-Ardenne (URCA), 51097 Reims, France"},{"name":"Service de M\u00e9decine Interne, Immunologie clinique et maladies infectieuses, Centre Hospitalier Universitaire Reims, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Berri","sequence":"additional","affiliation":[{"name":"EA-4684 CardioVir, Faculty of Medicine, University of Reims Champagne-Ardenne (URCA), 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Andreoletti","sequence":"additional","affiliation":[{"name":"EA-4684 CardioVir, Faculty of Medicine, University of Reims Champagne-Ardenne (URCA), 51097 Reims, France"},{"name":"Laboratoire de Virologie M\u00e9dicale et Mol\u00e9culaire, Centre Hospitalier Universitaire Reims, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/jmv.23284","article-title":"Early human enterovirus infections in healthy Swedish children participating in the PRODIA pilot study","volume":"84","author":"Hiekka","year":"2012","journal-title":"J. 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