{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:52:10Z","timestamp":1790070730911,"version":"4.0.1"},"reference-count":24,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003107","name":"Bundesministerium f\u00fcr Gesundheit","doi-asserted-by":"publisher","award":["ZMV I1-2517GHP-704"],"award-info":[{"award-number":["ZMV I1-2517GHP-704"]}],"id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002329","name":"Bundesamt f\u00fcr Gesundheit","doi-asserted-by":"publisher","award":["ZMV I1-2517WHO005"],"award-info":[{"award-number":["ZMV I1-2517WHO005"]}],"id":[{"id":"10.13039\/501100002329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002329","name":"Bundesamt f\u00fcr Gesundheit","doi-asserted-by":"publisher","award":["ZMVI1-2519GHP704"],"award-info":[{"award-number":["ZMVI1-2519GHP704"]}],"id":[{"id":"10.13039\/501100002329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FI 1781\/2-1"],"award-info":[{"award-number":["FI 1781\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GU 883\/4-1"],"award-info":[{"award-number":["GU 883\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["883\/5-1"],"award-info":[{"award-number":["883\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["RIA2016E-1609"],"award-info":[{"award-number":["RIA2016E-1609"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Lassa fever is a rodent-borne disease caused by Lassa virus (LASV). It causes fever, dizziness, vertigo, fatigue, coughing, diarrhea, internal bleeding and facial edema. The disease has been known in Guinea since 1960 but only anectodical acute cases have been reported to date. In January 2019, a 35-year-old man, a wood merchant from Kissidougou, Forest Guinea, presented himself at several health centers with persistent fever, frequent vomiting and joint pain. He was repeatedly treated for severe malaria, and died three weeks later in Mamou regional hospital. Differential diagnosis identified LASV as the cause of death. No secondary cases were reported. The complete LASV genome was obtained using next-generation sequencing. Phylogenetic analysis showed that this strain, namely the Kissidougou strain, belongs to the clade IV circulating in Guinea and Sierra Leone, and is thought to have emerged some 150 years ago. Due to the similarity of symptoms with malaria, Lassa fever is still a disease that is difficult to recognize and that may remain undiagnosed in health centers in Guinea.<\/jats:p>","DOI":"10.3390\/v12101062","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T09:28:08Z","timestamp":1600853288000},"page":"1062","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019"],"prefix":"10.3390","volume":"12","author":[{"given":"N\u2019Faly","family":"Magassouba","sequence":"first","affiliation":[{"name":"Laboratoire des Fi\u00e8vres H\u00e9morragiques en Guin\u00e9e, Conakry, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enogo","family":"Koivogui","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 Sanitaire, Ministry of Health, Conakry, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7223-244X","authenticated-orcid":false,"given":"Sory","family":"Conde","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 Sanitaire, Ministry of Health, Conakry, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Kone","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 Sanitaire, Ministry of Health, Conakry, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Koropogui","sequence":"additional","affiliation":[{"name":"Laboratoire des Fi\u00e8vres H\u00e9morragiques en Guin\u00e9e, Conakry, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barr\u00e8","family":"Soropogui","sequence":"additional","affiliation":[{"name":"Laboratoire des Fi\u00e8vres H\u00e9morragiques en Guin\u00e9e, Conakry, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifono","family":"Kekoura","sequence":"additional","affiliation":[{"name":"Laboratoire des Fi\u00e8vres H\u00e9morragiques en Guin\u00e9e, Conakry, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hinzmann","sequence":"additional","affiliation":[{"name":"Virology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany"},{"name":"Virology Department, German Center for Infection Research (DZIF), partner site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems, 20359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Virology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany"},{"name":"Virology Department, German Center for Infection Research (DZIF), partner site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems, 20359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakoba","family":"Keita","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 Sanitaire, Ministry of Health, Conakry, Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Duraffour","sequence":"additional","affiliation":[{"name":"Virology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany"},{"name":"Virology Department, German Center for Infection Research (DZIF), partner site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems, 20359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Fichet-Calvet","sequence":"additional","affiliation":[{"name":"Virology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany"},{"name":"Virology Department, German Center for Infection Research (DZIF), partner site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems, 20359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/227174a0","article-title":"Isolation and antigenic characterization of Lassa virus","volume":"227","author":"Buckley","year":"1970","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.4269\/ajtmh.1970.19.670","article-title":"Lassa fever, a new virus disease of man from West Africa","volume":"19","author":"Frame","year":"1970","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Fichet-Calvet, E., and Rogers, D.J. (2009). Risk maps of Lassa fever in West Africa. PLoS Negl. Trop. Dis., 3.","DOI":"10.1371\/journal.pntd.0000388"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/10408360490497456","article-title":"Lassa virus","volume":"41","author":"Gunther","year":"2004","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1126\/science.aau9343","article-title":"Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak","volume":"363","author":"Kafetzopoulou","year":"2019","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/jmv.1890400308","article-title":"Lassa virus activity in Guinea: Distribution of human antiviral antibody defined using enzyme-linked immunosorbent assay with recombinant antigen","volume":"40","author":"Lukashevich","year":"1993","journal-title":"J. Med. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/vbz.2006.0581","article-title":"Lassa virus-infected rodents in refugee camps in Guinea: A looming threat to public health in a politically unstable region","volume":"7","author":"Fair","year":"2007","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/vbz.2006.0520","article-title":"Fluctuation of abundance and Lassa virus prevalence in Mastomys natalensis in Guinea, West Africa","volume":"7","author":"Lecompte","year":"2007","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"21977","DOI":"10.1038\/srep21977","article-title":"Spatial and temporal evolution of Lassa virus in the natural host population in Upper Guinea","volume":"6","author":"Olschlager","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.3201\/eid1212.060812","article-title":"Mastomys natalensis and Lassa fever, West Africa","volume":"12","author":"Lecompte","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"25280","DOI":"10.1038\/srep25280","article-title":"New Hosts of The Lassa Virus","volume":"6","author":"Olayemi","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/15303660160025903","article-title":"Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations","volume":"1","author":"Bausch","year":"2001","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_13","first-page":"607","article-title":"El\u00e9ments de recherches clinico-\u00e9pid\u00e9miologiques et de laboratoire sur les fi\u00e8vres h\u00e9morragiques en Guin\u00e9e","volume":"80","author":"Boiro","year":"1987","journal-title":"B. Soc. Pathol. Exot."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6992","DOI":"10.1128\/JVI.74.15.6992-7004.2000","article-title":"Genetic diversity among Lassa virus strains","volume":"74","author":"Bowen","year":"2000","journal-title":"J. Virol."},{"key":"ref_15","unstructured":"ProMED-mail (2018, February 10). Lassa fever-West Africa (09): Liberia ex Guinea. Available online: https:\/\/promedmail.org\/promed-post\/?id=20180210.5620420."},{"key":"ref_16","unstructured":"ProMED-mail (2019, February 03). Lassa fever-West Africa (08): Guinea (MM). Available online: https:\/\/promedmail.org\/promed-post\/?id=6292809."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0035-9203(72)90272-6","article-title":"Lassa fever virological and serological studies","volume":"66","author":"Henderson","year":"1972","journal-title":"Trans. Roy. Soc. Trop. Med. Hyg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1128\/JCM.02351-09","article-title":"Improved detection of Lassa virus by reverse transcription-PCR targeting the 5\u2019 region of S RNA","volume":"48","author":"Olschlager","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/molbev\/mss075","article-title":"Bayesian phylogenetics with BEAUti and the BEAST 1.7","volume":"29","author":"Drummond","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/22221751.2020.1766381","article-title":"Households as hotspots of Lassa fever? Assessing the spatial distribution of Lassa virus-infected rodents in rural villages of Guinea","volume":"9","author":"Marien","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Olayemi, A., Adesina, A.S., Strecker, T., Magassouba, N., and Fichet-Calvet, E. (2020). Determining Ancestry between Rodent- and Human-Derived Virus Sequences in Endemic Foci: Towards a More Integral Molecular Epidemiology of Lassa Fever within West Africa. Biology, 9.","DOI":"10.3390\/biology9020026"},{"key":"ref_22","unstructured":"Jahrling, P.B., Geisbert, J., and Ibrahim, M.S. (2004, May 18). Direct Submission Lassa mammarenavirus, Available online: https:\/\/www.ncbi.nlm.nih.gov\/nuccore\/AY628201."},{"key":"ref_23","unstructured":"Rossi, S.L., Guerbois, M., Forrester, N.L., Ksiazek, T., Lin, D., Hari, K., and Weaver, S.C. (2016, March 24). Direct Submission Lassa mammarenavirus, Available online: https:\/\/www.ncbi.nlm.nih.gov\/nuccore\/KU978807."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S1473-3099(19)30486-4","article-title":"Lassa virus circulating in Liberia: A retrospective genomic characterisation","volume":"19","author":"Wiley","year":"2019","journal-title":"Lancet Infect. Dis."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/12\/10\/1062\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:12:55Z","timestamp":1760177575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/12\/10\/1062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,23]]},"references-count":24,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["v12101062"],"URL":"https:\/\/doi.org\/10.3390\/v12101062","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,23]]}}}