{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:36:18Z","timestamp":1790361378595,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>This is the first report of a successful treatment of a non-effusive feline infectious peritonitis (FIP) uveitis case using an oral adenosine nucleoside analogue drug and feline interferon omega, and alpha-1 acid glycoprotein (AGP) as an indicator of recovery. A 2-year-old male neutered Norwegian Forest Cat presented with uveitis, keratic precipitates, mesenteric lymphadenopathy and weight loss. The cat was hypergammaglobulinaemic and had a non-regenerative anaemia. Feline coronavirus (FCoV) RNA was detected in a mesenteric lymph node fine-needle aspirate by a reverse-transcriptase polymerase chain reaction\u2014non-effusive FIP was diagnosed. Prednisolone acetate eye drops were administered three times daily for 2 weeks. Oral adenosine nucleoside analogue (Mutian) treatment started. Within 50 days of Mutian treatment, the cat had gained over one kilogram in weight, his globulin level reduced from 77 to 51 g\/L and his haematocrit increased from 22 to 35%; his uveitis resolved and his sight improved. Serum AGP level reduced from 3100 to 400 \u03bcg\/mL (within normal limits). Symmetric dimethylarginine (SDMA) was above normal at 28 \u03bcg\/dL, reducing to 14 \u03bcg\/dL on the cessation of treatment; whether the SDMA increase was due to FIP lesions in the kidney or Mutian is unknown. Mutian treatment stopped and low-dose oral recombinant feline interferon omega begun\u2014the cat\u2019s recovery continued.<\/jats:p>","DOI":"10.3390\/v12111216","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T09:22:45Z","timestamp":1603790565000},"page":"1216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-2661","authenticated-orcid":false,"given":"Diane","family":"Addie","sequence":"first","affiliation":[{"name":"Feline Infectious Peritonitis and Coronavirus Website, 64470 Etchebar, Pyrenees, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Covell-Ritchie","sequence":"additional","affiliation":[{"name":"Independent Researcher, Maidstone ME14 5BF, Kent, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswald","family":"Jarrett","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fosbery","sequence":"additional","affiliation":[{"name":"Newnham Court Veterinary Hospital, Bearsted Road, Weavering, Maidstone ME14 5E, Kent, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2460\/ajvr.1995.56.04.429","article-title":"The risk of feline infectious peritonitis in cats naturally infected with feline coronavirus","volume":"56","author":"Addie","year":"1995","journal-title":"Am. 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