{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T18:51:55Z","timestamp":1792867915186,"version":"4.5.0"},"reference-count":66,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006512","name":"School of Medicine, Duke University","doi-asserted-by":"publisher","award":["Duke\/Duke-NUS Pilot Grant"],"award-info":[{"award-number":["Duke\/Duke-NUS Pilot Grant"]}],"id":[{"id":"10.13039\/100006512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Epstein\u2013Barr-virus-associated Gastric Cancer (EBVaGC) comprises approximately 10% of global gastric cancers and is known to be the most hypermethylated of all tumor types. EBV infection has been shown to directly induce the hypermethylation of both the host and viral genome following initial infection of gastric epithelial cells. Many studies have been completed in an attempt to identify genes that frequently become hypermethylated and therefore significant pathways that become silenced to promote tumorigenesis. It is clear that EBV-induced hypermethylation silences key tumor suppressor genes, cell cycle genes and cellular differentiation factors to promote a highly proliferative and poorly differentiated cell population. EBV infection has been shown to induce methylation in additional malignancies including Nasopharyngeal Carcinoma and Burkitt\u2019s Lymphoma though not to the same level as in EBVaGC. Lastly, some genes silenced in EBVaGC are common to other heavily methylated tumors such as colorectal and breast tumors; however, some genes are unique to EBVaGC and can provide insights into the major pathways involved in tumorigenesis.<\/jats:p>","DOI":"10.3390\/v12111222","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T11:43:06Z","timestamp":1603885386000},"page":"1222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis"],"prefix":"10.3390","volume":"12","author":[{"given":"Lyla J.","family":"Stanland","sequence":"first","affiliation":[{"name":"Center for Virology, Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-1907","authenticated-orcid":false,"given":"Micah A.","family":"Luftig","sequence":"additional","affiliation":[{"name":"Center for Virology, Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc.2016.92","article-title":"Epstein-Barr virus: More than 50 years old and still providing surprises","volume":"16","author":"Young","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_2","first-page":"377","article-title":"Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction","volume":"3","author":"Burke","year":"1990","journal-title":"Mod. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1756-9966-28-14","article-title":"Characteristics of Epstein-Barr virus-associated gastric cancer: A study of 235 cases at a comprehensive cancer center in U.S.A","volume":"28","author":"Truong","year":"2009","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0002-9440(10)64901-2","article-title":"Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma","volume":"160","author":"Kang","year":"2002","journal-title":"Am. J. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1349-7006.2003.tb01355.x","article-title":"Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virus","volume":"94","author":"Chong","year":"2003","journal-title":"Cancer Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1750-9378-5-27","article-title":"Epstein-Barr virus-specific methylation of human genes in gastric cancer cells","volume":"5","author":"Ryan","year":"2010","journal-title":"Infect. Agents Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1053\/j.gastro.2014.08.036","article-title":"Integrative identification of Epstein-Barr virus-associated mutations and epigenetic alterations in gastric cancer","volume":"147","author":"Liang","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/cam4.451","article-title":"Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma","volume":"4","author":"Dai","year":"2015","journal-title":"Cancer Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Research Network (2014). Comprehensive molecular characterization of gastric adenocarcinoma. Nature, 513, 202\u2013209.","DOI":"10.1038\/nature13480"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/path.4909","article-title":"Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells","volume":"242","author":"Matsusaka","year":"2017","journal-title":"J. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"81512","DOI":"10.18632\/oncotarget.13130","article-title":"TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection","volume":"7","author":"Funata","year":"2016","journal-title":"Oncotarget"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7924","DOI":"10.1038\/s41598-017-08370-7","article-title":"Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus","volume":"7","author":"Okabe","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ccell.2017.11.018","article-title":"Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer","volume":"33","author":"Huang","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ccell.2018.03.010","article-title":"Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas","volume":"33","author":"Liu","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e01332-19","DOI":"10.1128\/mBio.01332-19","article-title":"Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from the Cell Cycle","volume":"10","author":"Eichelberg","year":"2019","journal-title":"mBio"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11442","DOI":"10.1128\/JVI.00972-14","article-title":"Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes","volume":"88","author":"Birdwell","year":"2014","journal-title":"J. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Edwards, R.H., Dekroon, R., and Raab-Traub, N. (2019). Alterations in cellular expression in EBV infected epithelial cell lines and tumors. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1008071"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/cncr.27724","article-title":"Genome-wide identification of Epstein-Barr virus-driven promoter methylation profiles of human genes in gastric cancer cells","volume":"119","author":"Zhao","year":"2013","journal-title":"Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7187","DOI":"10.1158\/0008-5472.CAN-11-1349","article-title":"Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes","volume":"71","author":"Matsusaka","year":"2011","journal-title":"Cancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"55265","DOI":"10.18632\/oncotarget.19423","article-title":"Histone modification alteration coordinated with acquisition of promoter DNA methylation during Epstein-Barr virus infection","volume":"8","author":"Funata","year":"2017","journal-title":"Oncotarget"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1002\/ijc.27893","article-title":"Epstein-Barr virus-induced epigenetic alterations following transient infection","volume":"132","author":"Queen","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1158\/0008-5472.CAN-08-3070","article-title":"Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma","volume":"69","author":"Hino","year":"2009","journal-title":"Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature12750","article-title":"TET enzymes, TDG and the dynamics of DNA demethylation","volume":"502","author":"Kohli","year":"2013","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"40025","DOI":"10.18632\/oncotarget.9474","article-title":"Higher methylation intensity induced by EBV LMP1 via NF-kappaB\/DNMT3b signaling contributes to silencing of PTEN gene","volume":"7","author":"Peng","year":"2016","journal-title":"Oncotarget"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11668","DOI":"10.1158\/0008-5472.CAN-06-2194","article-title":"Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH(2)-terminal kinase signaling","volume":"66","author":"Tsai","year":"2006","journal-title":"Cancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"E5199","DOI":"10.1073\/pnas.1503806112","article-title":"Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection","volume":"112","author":"Saha","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"14144","DOI":"10.1073\/pnas.1821752116","article-title":"EBV infection is associated with histone bivalent switch modifications in squamous epithelial cells","volume":"116","author":"Leong","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/nar\/gkt886","article-title":"Epstein-Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation","volume":"42","author":"Hernando","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12276","DOI":"10.1128\/JVI.77.22.12276-12284.2003","article-title":"Epstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells","volume":"77","author":"Morrison","year":"2003","journal-title":"J. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"154","DOI":"10.5501\/wjv.v1.i6.154","article-title":"Roles of the PI3K\/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implications","volume":"1","author":"Chen","year":"2012","journal-title":"World J. Virol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1038\/s41467-019-11011-4","article-title":"Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia","volume":"10","author":"Soutto","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8619","DOI":"10.1038\/sj.onc.1207905","article-title":"Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras\/PI3K\/Akt pathway","volume":"23","author":"Portis","year":"2004","journal-title":"Oncogene"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1158\/0008-5472.CAN-07-3027","article-title":"Survival advantage of EBV-associated gastric carcinoma: Survivin up-regulation by viral latent membrane protein 2A","volume":"68","author":"Hino","year":"2008","journal-title":"Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.3390\/v4123420","article-title":"Epstein-Barr Virus (EBV)-associated gastric carcinoma","volume":"4","author":"Iizasa","year":"2012","journal-title":"Viruses"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1007\/s11033-020-05341-6","article-title":"Alterations of cell cycle genes in cancer: Unmasking the role of cancer stem cells","volume":"47","author":"Caglar","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5230\/jgc.2016.16.1.1","article-title":"Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response","volume":"16","author":"Cho","year":"2016","journal-title":"J. Gastric Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1073\/pnas.88.19.8332","article-title":"Expression of proteins encoded by Epstein-Barr virus trans-activator genes depends on the differentiation of epithelial cells in oral hairy leukoplakia","volume":"88","author":"Becker","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1128\/jvi.65.6.2868-2874.1991","article-title":"Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia","volume":"65","author":"Young","year":"1991","journal-title":"J. Virol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","article-title":"Epstein-Barr virus: 40 years on","volume":"4","author":"Young","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e22509","DOI":"10.7554\/eLife.22509","article-title":"Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection","volume":"6","author":"Price","year":"2017","journal-title":"eLife"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"E86","DOI":"10.1111\/j.1749-6632.2010.05711.x","article-title":"Gut-associated lymphoid tissue, T cell trafficking, and chronic intestinal inflammation","volume":"1207","author":"Koboziev","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature13863","article-title":"Modelling human development and disease in pluripotent stem-cell-derived gastric organoids","volume":"516","author":"McCracken","year":"2014","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jcmgh.2016.05.006","article-title":"Stomach Organ and Cell Lineage Differentiation: From Embryogenesis to Adult Homeostasis","volume":"2","author":"Willet","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"dmm033373","DOI":"10.1242\/dmm.033373","article-title":"Plasticity of differentiated cells in wound repair and tumorigenesis, part I: Stomach and pancreas","volume":"11","author":"Burclaff","year":"2018","journal-title":"Dis. Models Mech."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"E3473","DOI":"10.1073\/pnas.1202637109","article-title":"Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells","volume":"109","author":"Tsang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1002\/ijc.25173","article-title":"Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: Regulation of infection and phenotypic characterization","volume":"127","author":"Tsang","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Yoon, J.H., Min, K., and Lee, S.K. (2020). Epstein-Barr Virus miR-BART17-5p Promotes Migration and Anchorage-Independent Growth by Targeting Kruppel-Like Factor 2 in Gastric Cancer. Microorganisms, 8.","DOI":"10.3390\/microorganisms8020258"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9593","DOI":"10.1073\/pnas.1202910109","article-title":"Infection of Epstein-Barr virus in a gastric carcinoma cell line induces anchorage independence and global changes in gene expression","volume":"109","author":"Marquitz","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1128\/JVI.73.2.1286-1292.1999","article-title":"Epstein-Barr virus promotes epithelial cell growth in the absence of EBNA2 and LMP1 expression","volume":"73","author":"Nishikawa","year":"1999","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Nawandar, D.M., Wang, A., Makielski, K., Lee, D., Ma, S., Barlow, E., Reusch, J., Jiang, R., Wille, C.K., and Greenspan, D. (2015). Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1005195"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"E7257","DOI":"10.1073\/pnas.1513432112","article-title":"5-hydroxymethylation of the EBV genome regulates the latent to lytic switch","volume":"112","author":"Wille","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Fukayama, M., Abe, H., Kunita, A., Shinozaki-Ushiku, A., Matsusaka, K., Ushiku, T., and Kaneda, A. (2019). Thirty years of Epstein-Barr virus-associated gastric carcinoma. Virchows Arch.","DOI":"10.1007\/s00428-019-02724-4"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.semcancer.2014.01.003","article-title":"Epigenetic regulation of EBV persistence and oncogenesis","volume":"26","author":"Tempera","year":"2014","journal-title":"Semin. Cancer Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.coviro.2017.07.017","article-title":"Epstein-Barr virus: A master epigenetic manipulator","volume":"26","author":"Scott","year":"2017","journal-title":"Curr. Opin. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1128\/JVI.72.9.7075-7083.1998","article-title":"The Epstein-Barr virus major latent promoter Qp is constitutively active, hypomethylated, and methylation sensitive","volume":"72","author":"Tao","year":"1998","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.micinf.2009.12.001","article-title":"Immune responses to Epstein-Barr virus: Molecular interactions in the virus evasion of CD8+ T cell immunity","volume":"12","author":"Rowe","year":"2010","journal-title":"Microbes Infect."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1128\/jvi.63.7.3135-3141.1989","article-title":"5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt\u2019s lymphoma line rael","volume":"63","author":"Masucci","year":"1989","journal-title":"J. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-3-319-24738-0_3","article-title":"Epigenetic Alterations in Epstein-Barr Virus-Associated Diseases","volume":"879","author":"Niller","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.1038\/s41598-017-05713-2","article-title":"Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines","volume":"7","author":"Gruffat","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/ng.3413","article-title":"DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control","volume":"47","author":"Kretzmer","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40246-017-0106-6","article-title":"Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines","volume":"11","author":"Taniguchi","year":"2017","journal-title":"Hum. Genom."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/j.febslet.2010.12.001","article-title":"Dissecting DNA hypermethylation in cancer","volume":"585","author":"Estecio","year":"2011","journal-title":"FEBS Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/gr.117523.110","article-title":"Genome-scale analysis of aberrant DNA methylation in colorectal cancer","volume":"22","author":"Hinoue","year":"2012","journal-title":"Genome Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2013.09.034","article-title":"The somatic genomic landscape of glioblastoma","volume":"155","author":"Brennan","year":"2013","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Network (2012). Comprehensive molecular portraits of human breast tumours. Nature, 490, 61\u201370.","DOI":"10.1038\/nature11412"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Network (2012). Comprehensive molecular characterization of human colon and rectal cancer. Nature, 487, 330\u2013337.","DOI":"10.1038\/nature11252"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/12\/11\/1222\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:30:10Z","timestamp":1760178610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/12\/11\/1222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":66,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["v12111222"],"URL":"https:\/\/doi.org\/10.3390\/v12111222","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]}}}