{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:59:03Z","timestamp":1776488343733,"version":"3.51.2"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Dengue manifestations range from a mild form, dengue fever (DF), to more severe forms such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The ability of the host to present one of these clinical forms could be related to polymorphisms located in genes of the Toll-like receptors (TLRs) which activate the pro-inflammatory response. Therefore, the genotyping of single nucleotide genetic polymorphisms (SNPs) in TLR3 (rs3775291 and rs6552950), TLR4 (rs2737190, rs10759932, rs4986790, rs4986791, rs11536865, and rs10983755), TLR7 (rs179008 and rs3853839), and TLR8 (rs3764880, rs5741883, rs4830805, and rs1548731) was carried out in non-genetically related DHF patients, DF patients, and general population (GP) subjects. The SNPs were analyzed by real-time PCR by genotyping assays from Applied Biosystems\u00ae. The codominance model showed that dengue patients had a lower probability of presenting the TLR4-rs2737190-G\/G genotype (odds ratio (OR) (95% CI) = 0.34 (0.14\u20130.8), p = 0.038). Dengue patients showed a lower probability of presenting TLR4-rs11536865-G\/C genotype (OR (95% CI) = 0.19 (0.05\u20130.73), p = 0.0092) and had a high probability of presenting the TACG haplotype, but lower probability of presenting the TGCG haplotype in the TLR4 compared to GP individuals (OR (95% CI) = 0.55 (0.35\u20130.86), p = 0.0084). In conclusion, the TLR4-rs2737190-G\/G and TLR4-rs11536865-G\/C genotypes and TGCG haplotype were associated with protection from dengue.<\/jats:p>","DOI":"10.3390\/v12111230","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T21:21:00Z","timestamp":1604006460000},"page":"1230","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-3257","authenticated-orcid":false,"given":"Araceli","family":"Posadas-Mondrag\u00f3n","sequence":"first","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis, Colonia Casco de Santo Tomas, Delegaci\u00f3n Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Leopoldo","family":"Aguilar-Faisal","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis, Colonia Casco de Santo Tomas, Delegaci\u00f3n Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Zu\u00f1iga","sequence":"additional","affiliation":[{"name":"Departamento de Zoolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Plan de Ayala, Colonia Casco de Santo Tomas, Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4399-4618","authenticated-orcid":false,"given":"Jonathan Javier","family":"Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica, Departamento de Gen\u00e9tica, Instituto Nacional de Rehabilitaci\u00f3n-LGII, Calzada M\u00e9xico Xochimilco No. 289, Colonia Arenal de Guadalupe, Ciudad de M\u00e9xico 14389, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Angel","family":"Santiago-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Plan de Ayala, Colonia Casco de Santo Tomas, Delegaci\u00f3n Miguel Hidalgo, Ciudad de Mexico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Guill\u00e9n-Salom\u00f3n","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Planeaci\u00f3n y Enlace Institucional, Delegaci\u00f3n Veracruz Norte, Instituto Mexicano del Seguro Social, Lomas del Estadio S\/N Xalapa, Veracruz 91090, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-3920","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Alc\u00e1ntara-Farf\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Plan de Ayala, Colonia Casco de Santo Tomas, Delegaci\u00f3n Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa","family":"Arellano-Flores","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Enfermedades Endocrinas, Hospital de Especialidades, Centro M\u00e9dico, Nacional siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores, Delegaci\u00f3n Cuauht\u00e9moc, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4096-0079","authenticated-orcid":false,"given":"Juan Santiago","family":"Salas-Benito","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomedicina Molecular III (Virolog\u00eda) de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Nacional de Medicina y Homeopat\u00eda, Instituto Polit\u00e9cnico Nacional, Guillermo Massieu Helguera 239, La Escalera, Gustavo A. Madero, Ciudad de M\u00e9xico 07320, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo M.","family":"Neri-Baz\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis, Colonia Casco de Santo Tomas, Delegaci\u00f3n Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucero","family":"Luna-Rojas","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis, Colonia Casco de Santo Tomas, Delegaci\u00f3n Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Marineth","family":"Avila-Trejo","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n de la Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis, Colonia Casco de Santo Tomas, Delegaci\u00f3n Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Ch\u00e1vez-Negrete","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Educaci\u00f3n M\u00e9dica Continua, Comit\u00e9 Normativo Nacional de Medicina General, Cuauht\u00e9moc 330, Colonia Doctores, Delegaci\u00f3n Cuauht\u00e9moc CDMX 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4269\/ajtmh.12-0023","article-title":"Determination of viremia and concentration of circulating nonstructural protein 1 in patients infected with dengue virus in Mexico","volume":"88","author":"Flores","year":"2013","journal-title":"Am. 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