{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:55:19Z","timestamp":1791352519270,"version":"4.3.1"},"reference-count":45,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["440573\/2016-5"],"award-info":[{"award-number":["440573\/2016-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.130813\/2016-01"],"award-info":[{"award-number":["88881.130813\/2016-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["008\/2016"],"award-info":[{"award-number":["008\/2016"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Departamento de Ci\u00eancia e Tecnologia do Minist\u00e9rio da Sa\u00fade","award":["440573\/2016-5"],"award-info":[{"award-number":["440573\/2016-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The short duration of viremia, low blood viral load, inaccessibility to timely specific diagnostic tests, and cross-reactions with other flaviviruses have hindered laboratory confirmation of Congenital Zika Syndrome (CZS). This study analyzes the positivity of the plaque reduction neutralization test (PRNT) in children with clinical or imaging characteristics of CZS and its association with laboratory, clinical, and imaging characteristics. The 94 clinical cases of CZS submitted to the ZIKV PRNT90 test were followed from 2016 to 2018. The mean age of children at PRNT90 collection was 22 \u00b1 6 months Standard Deviation. The ZIKV PRNT90 was positive (titer \u2265 10) in 40 (42.5%) children. ZIKV PRNT90 positivity was associated with severe microcephaly in newborns (p = 0.016), lower head circumference z-score at birth (p = 0.043) and 24 months of age (p = 0.031), and severe reduction of the cerebral parenchyma volume (p = 0.021), expressing greater disease severity. Negative PRNT90 in children with characteristic signs of CZS may be due to false-negative results, indicating that the diagnosis of CZS should be primarily syndromic.<\/jats:p>","DOI":"10.3390\/v12111244","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T21:39:56Z","timestamp":1604180396000},"page":"1244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Plaque Reduction Neutralization Test (PRNT) in the Congenital Zika Syndrome: Positivity and Associations with Laboratory, Clinical, and Imaging Characteristics"],"prefix":"10.3390","volume":"12","author":[{"given":"Mariz\u00e9lia R. C.","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Medicine III, Federal University of Maranh\u00e3o, Pra\u00e7a Gon\u00e7alves Dias, 21, Centro, S\u00e3o Lu\u00eds CEP 65020-240, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Khouri","sequence":"additional","affiliation":[{"name":"Laboratory of Vector-Borne Infectious Diseases, Gon\u00e7alo Moniz Institute, Fiocruz-Bahia, Rua Waldemar Falc\u00e3o, 121, Candeal, Salvador CEP 40296-710, BA, Brazil"},{"name":"Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Bahia, Pra\u00e7a XV de Novembro, s\/n\u2013Largo do Terreiro de Jesus, Salvador CEP 40026-010, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia S.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Reference Center on Neurodevelopment, Assistance and Rehabilitation of Children\/NINAR\u2013 Health Secretariat of the State of Maranh\u00e3o, Av. dos Holandeses, s\/n, S\u00e3o Lu\u00eds CEP 65077-357, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R. F. C.","family":"Branco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Federal University of Maranh\u00e3o, Pra\u00e7a Madre Deus, 2, Madre Deus, S\u00e3o Lu\u00eds CEP 65025-560, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ros\u00e2ngela F. L.","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federal University of Maranh\u00e3o, Rua Bar\u00e3o de Itapary, 155, Centro, S\u00e3o Lu\u00eds CEP 65020-070, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine P. F.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Federal University of Maranh\u00e3o, Pra\u00e7a Gon\u00e7alves Dias, 21, Centro, S\u00e3o Lu\u00eds CEP 65020-240, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4806-7752","authenticated-orcid":false,"given":"Maria T. S. S. B.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federal University of Maranh\u00e3o, Rua Bar\u00e3o de Itapary, 155, Centro, S\u00e3o Lu\u00eds CEP 65020-070, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-3186","authenticated-orcid":false,"given":"Gl\u00e1ucio A.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Sarah Network of Neurorehabilitation Hospitals, Av. Luis Rocha, s\/n, Monte Castelo, S\u00e3o Lu\u00eds CP 65035-270, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella C. R.","family":"Borges","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department, Federal University of S\u00e3o Paulo, Rua Napole\u00e3o de Barros, 800, S\u00e3o Paulo CEP 04024-002, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana H. M.","family":"Takahasi","sequence":"additional","affiliation":[{"name":"Sarah Network of Neurorehabilitation Hospitals, Av. Luis Rocha, s\/n, Monte Castelo, S\u00e3o Lu\u00eds CP 65035-270, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edllian N.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Human Immunology, Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1730, Cidade Universit\u00e1ria, S\u00e3o Paulo CEP 05508-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana K. T.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federal University of Maranh\u00e3o, Rua Bar\u00e3o de Itapary, 155, Centro, S\u00e3o Lu\u00eds CEP 65020-070, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-533X","authenticated-orcid":false,"given":"Tamires B.","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federal University of Maranh\u00e3o, Rua Bar\u00e3o de Itapary, 155, Centro, S\u00e3o Lu\u00eds CEP 65020-070, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-9380","authenticated-orcid":false,"given":"Luciana C.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federal University of Maranh\u00e3o, Rua Bar\u00e3o de Itapary, 155, Centro, S\u00e3o Lu\u00eds CEP 65020-070, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvina C.","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Tropical Medicine, University of S\u00e3o Paulo, Av. 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