{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:06:49Z","timestamp":1790262409385,"version":"4.1.0"},"reference-count":94,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["170170 and 180599"],"award-info":[{"award-number":["170170 and 180599"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","award":["XXXXX"],"award-info":[{"award-number":["XXXXX"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The zinc finger proteins make up a significant part of the proteome and perform a huge variety of functions in the cell. The CCCH-type zinc finger proteins have gained attention due to their unusual ability to interact with RNA and thereby control different steps of RNA metabolism. Since virus infections interfere with RNA metabolism, dynamic changes in the CCCH-type zinc finger proteins and virus replication are expected to happen. In the present review, we will discuss how three CCCH-type zinc finger proteins, ZC3H11A, MKRN1, and U2AF1, interfere with human adenovirus replication. We will summarize the functions of these three cellular proteins and focus on their potential pro- or anti-viral activities during a lytic human adenovirus infection.<\/jats:p>","DOI":"10.3390\/v12111322","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T07:41:00Z","timestamp":1605685260000},"page":"1322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections"],"prefix":"10.3390","volume":"12","author":[{"given":"Zamaneh","family":"Hajikhezri","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Darweesh","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden"},{"name":"Department of Microbiology and Immunology, Al-Azhr University, Assiut 11651, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Akusj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-367X","authenticated-orcid":false,"given":"Tanel","family":"Punga","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1039\/C7MT00256D","article-title":"Metal binding properties of zinc fingers with a naturally altered metal binding site","volume":"10","author":"Kluska","year":"2018","journal-title":"Metallomics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/j.1460-2075.1985.tb03825.x","article-title":"Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes","volume":"4","author":"Miller","year":"1985","journal-title":"EMBO J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0014-5793(85)80723-7","article-title":"The primary structure of transcription factor TFIIIA has 12 consecutive repeats","volume":"186","author":"Brown","year":"1985","journal-title":"FEBS Lett."},{"key":"ref_4","first-page":"4776","article-title":"Role of TFIIIA zinc fingers in vivo: Analysis of single-finger function in developing Xenopus embryos","volume":"13","author":"Rollins","year":"1993","journal-title":"Mol. 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