{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:28:34Z","timestamp":1785756514186,"version":"3.56.0"},"reference-count":43,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3\u20134 days after the appearance of the respiratory signs (caught and gasping breath). Microbiological analysis revealed absence of pathogenic bacteria whilst Real-time PCR identified the presence of RNA from Bovine Coronavirus (BCoV) in several organs: lungs, small intestine (jejunum), mediastinal lymph nodes, liver and placenta. BCoV was therefore hypothesized to play a role in the lethal pulmonary infection. Like the other CoVs, BCoV is able to cause different syndromes. Its role in calf diarrhea and in mild respiratory disease is well known: we report instead the involvement of this virus in a severe and fatal respiratory disorder, with symptoms and disease evolution resembling those of Severe Acute Respiratory Syndromes (SARS).<\/jats:p>","DOI":"10.3390\/v12111331","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T10:46:26Z","timestamp":1605782786000},"page":"1331","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fatal Interstitial Pneumonia Associated with Bovine Coronavirus in Cows from Southern Italy"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-7445","authenticated-orcid":false,"given":"Maria Grazia","family":"Amoroso","sequence":"first","affiliation":[{"name":"Unit of Virology, Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lucifora","sequence":"additional","affiliation":[{"name":"Section of Vibo Valentia, Experimental Zooprophylactic Institute of Southern Italy, Contrada Piano di Bruno, 89852 Mileto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Degli Uberti","sequence":"additional","affiliation":[{"name":"Unit of Virology, Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Serra","sequence":"additional","affiliation":[{"name":"Unit of Virology, Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"De Luca","sequence":"additional","affiliation":[{"name":"Unit of Virology, Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Borriello","sequence":"additional","affiliation":[{"name":"Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"De Domenico","sequence":"additional","affiliation":[{"name":"Freelance Veterinary, Ordine dei Veterinari di Vibo Valentia, 89900 Vibo Valentia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Brandi","sequence":"additional","affiliation":[{"name":"Unit of Virology, Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concetta","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bove","sequence":"additional","affiliation":[{"name":"Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita Georgia","family":"Riccardi","sequence":"additional","affiliation":[{"name":"Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Galiero","sequence":"additional","affiliation":[{"name":"Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Fusco","sequence":"additional","affiliation":[{"name":"Unit of Virology, Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108693","DOI":"10.1016\/j.vetmic.2020.108693","article-title":"Novel Human Coronavirus (SARS-CoV-2): A Lesson from Animal Coronaviruses","volume":"244","author":"Decaro","year":"2020","journal-title":"Vet. 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