{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:26:59Z","timestamp":1790303219380,"version":"4.1.0"},"reference-count":13,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nacional Council for Scientiic and Technological Development (CNPq)","award":["400911\/2018-3n"],"award-info":[{"award-number":["400911\/2018-3n"]}]},{"name":"Ministry of Health of Brazil DECIT","award":["TED 51\/2019"],"award-info":[{"award-number":["TED 51\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The epidemic transmission of Zika virus (ZIKV) in Brazil has been identified as a cause of microcephaly and other neurological malformations in the babies of ZIKV-infected women. The frequency of adverse outcomes of Zika virus infection (ZIKVi) in pregnancy differs depending on the characteristics of exposure to infection, the time of recruitment of research participants, and the outcomes to be observed. This study provides a descriptive analysis\u2014from the onset of symptoms to delivery\u2014of a cohort registered as having maternal ZIKVi in pregnancy, from November 2015 to December 2016. Suspected cases were registered at a referral center for infectious and tropical diseases in Manaus, in the Amazonian region of Brazil. Of 834 women notified, 762 women with confirmed pregnancies were enrolled. Reverse-transcriptase polymerase chain reaction (RT-PCR) confirmed ZIKVi in 42.3% of the cohort. In 35.2% of the cohort, ZIKV was the sole infection identified. Severe adverse pregnancy outcomes (miscarriage, stillbirth, or microcephaly) were observed in both RT-PCR ZIKV-positive (5.0%) and ZIKV-negative (1.8%) cases (RR 3.1; 95% IC 1.4\u20137.3; p &lt; 0.05), especially during the first trimester of pregnancy (RR 6.2, 95% IC 2.3\u201316.5; p &lt; 0.001). Although other infectious rash diseases were observed in the pregnant women in the study, having confirmed maternal ZIKVi was the most important risk factor for serious adverse pregnancy events.<\/jats:p>","DOI":"10.3390\/v12121362","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T21:00:57Z","timestamp":1606683657000},"page":"1362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-1032","authenticated-orcid":false,"given":"Elijane de F\u00e1tima","family":"Redivo","sequence":"first","affiliation":[{"name":"Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-4931","authenticated-orcid":false,"given":"Camila","family":"B\u00f4tto Menezes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil"},{"name":"Department of Medicine, School of Health Sciences, University of Amazonas State, Manaus 69065-000, Brazil"},{"name":"Department of Malaria, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia","family":"da Costa Castilho","sequence":"additional","affiliation":[{"name":"Department of Virology, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-116X","authenticated-orcid":false,"given":"Marianna","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Health Sciences, University of Amazonas State, Manaus 69065-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evela","family":"da Silva Magno","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria das Gra\u00e7as","family":"Gomes Saraiva","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salete Sara","family":"Alvarez Fernandes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7041-620X","authenticated-orcid":false,"given":"Anny Beatriz","family":"Costa Antony de Andrade","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Living Conditions and Health Situations in the Amazon PPGVIDA, Le\u00f4nidas &amp; Maria Deane Institute, Manaus 69057-070, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria das Gra\u00e7as","family":"Costa Alecrim","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil"},{"name":"Department of Malaria, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor Ernestina","family":"Martinez-Espinosa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil"},{"name":"Department of Malaria, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil"},{"name":"Postgraduate Program in Living Conditions and Health Situations in the Amazon PPGVIDA, Le\u00f4nidas &amp; Maria Deane Institute, Manaus 69057-070, Amazonas, Brazil"},{"name":"Laboratory of Territory, Environment, Health and Sustainability, Le\u00f4nidas &amp; Maria Deane Institute, Manaus 69057-070, Fiocruz Amazonia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3201\/eid2110.150847","article-title":"Zika Virus Outbreak, Bahia, Brazil","volume":"21","author":"Campos","year":"2015","journal-title":"Emerg. 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