{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:34:36Z","timestamp":1783103676323,"version":"3.54.6"},"reference-count":55,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["201870\/Z\/16\/Z"],"award-info":[{"award-number":["201870\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205377\/Z\/16\/Z"],"award-info":[{"award-number":["205377\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation programme","award":["734584"],"award-info":[{"award-number":["734584"]}]},{"name":"Wellcome Trust  - Research Enrichment in Epidemic Situations","award":["107779\/Z\/15\/Z"],"award-info":[{"award-number":["107779\/Z\/15\/Z"]}]},{"name":"Wellcome Trust  - Research Enrichment in Epidemic Situations","award":["ER1505 & ER1601"],"award-info":[{"award-number":["ER1505 & ER1601"]}]},{"name":"Medical Research Council on behalf of the Newton Fund and Wellcome Trust","award":["MC_PC_15088"],"award-info":[{"award-number":["MC_PC_15088"]}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["APQ-0192-4.01\/17"],"award-info":[{"award-number":["APQ-0192-4.01\/17"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["309722\/2017-9"],"award-info":[{"award-number":["309722\/2017-9"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306708\/2014-0"],"award-info":[{"award-number":["306708\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["440839\/2016-5"],"award-info":[{"award-number":["440839\/2016-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["837058\/2016"],"award-info":[{"award-number":["837058\/2016"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained the presence and describe endocrine dysfunction in 30 children with severe Zika-related microcephaly from the MERG Pediatric Cohort, referred for endocrinological evaluation between February and August 2019. Of the 30 children, 97% had severe microcephaly. The average age at the endocrinological consultation was 41 months and 53% were female. The most frequently observed endocrine dysfunctions comprised short stature, hypothyroidism, obesity and variants early puberty. These dysfunctions occurred alone 57% or in combination 43%. We found optic nerve hypoplasia (6\/21) and corpus callosum hypoplasia (20\/21). Seizure crises were reported in 86% of the children. The most common\u2014and clinically important\u2014endocrine dysfunctions were pubertal dysfunctions, thyroid disease, growth impairment, and obesity. These dysfunctions require careful monitoring and signal the need for endocrinological evaluation in children with Zika-related microcephaly, in order to make early diagnoses and implement appropriate treatment when necessary.<\/jats:p>","DOI":"10.3390\/v13010001","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T20:39:29Z","timestamp":1608669569000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil"],"prefix":"10.3390","volume":"13","author":[{"given":"Andr\u00e9ia","family":"Veras Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Tropical Medicine, Health Sciences Center, Federal University of Pernambuco, Recife 50670-901, Brazil"},{"name":"Unit Endocrinology, Oswaldo Cruz University Hospital, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dem\u00f3crito de B.","family":"Miranda-Filho","sequence":"additional","affiliation":[{"name":"Postgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edbia Cristina","family":"Rocha Vilela","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Health Sciences Center, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina Coeli Ferreira","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department Pediatric Infectious Disease, Oswaldo Cruz University Hospital, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalia V. B.","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-2099","authenticated-orcid":false,"given":"R\u00f4mulo A. L.","family":"de Vasconcelos","sequence":"additional","affiliation":[{"name":"Postgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angela","family":"Wanderley Rocha","sequence":"additional","affiliation":[{"name":"Department Pediatric Infectious Disease, Oswaldo Cruz University Hospital, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-2107","authenticated-orcid":false,"given":"Sophie Helena","family":"Eickmann","sequence":"additional","affiliation":[{"name":"Maternal and Child Department, Health Sciences Center, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marli Ten\u00f3rio","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Unit of Oswaldo Cruz Foundation (Fiocruz), Research Center Aggeu Magalh\u00e3es (CPqAM), Recife 50670-420, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana O.","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Altino Ventura Foundation, Recife 52171-011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-5693","authenticated-orcid":false,"given":"Ulisses Ramos","family":"Montarroyos","sequence":"additional","affiliation":[{"name":"Postgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Mertens Brainer","sequence":"additional","affiliation":[{"name":"Postgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Durce","family":"Costa Gomes","sequence":"additional","affiliation":[{"name":"Postgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-4732","authenticated-orcid":false,"given":"Paula Fabiana Sobral","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2491-0688","authenticated-orcid":false,"given":"Celina M. T.","family":"Martelli","sequence":"additional","affiliation":[{"name":"Unit of Oswaldo Cruz Foundation (Fiocruz), Research Center Aggeu Magalh\u00e3es (CPqAM), Recife 50670-420, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-2288","authenticated-orcid":false,"given":"Elizabeth B.","family":"Brickley","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A. A.","family":"Ximenes","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Health Sciences Center, Federal University of Pernambuco, Recife 50670-901, Brazil"},{"name":"Department of Internal Medicine, University of Pernambuco, Recife 50100-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2105\/AJPH.2016.303115","article-title":"Rodrigues Initial Description of the presumed congenital Zika Syndrome","volume":"106","author":"Martelli","year":"2016","journal-title":"Am. J. Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1056\/NEJMc1603617","article-title":"Computed Tomographic Findings in Microcephaly Associated with Zika Virus","volume":"374","author":"Hazin","year":"2016","journal-title":"N. Engl. J. 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