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The YF17DD induces polyvalent responses, with a TH1\/TH2 CD4+ profile, robust T CD8+ responses, and synthesis of interferon-gamma (IFN-\u03b3), culminating in high titers of neutralizing antibodies. Furthermore, C-type lectin domain containing 5A (CLEC5A) has been implicated in innate outcomes in other flaviviral infections. Here, we conducted a follow-up study in volunteers immunized with YF17DD, investigating the humoral response, cellular phenotypes, gene expression, and single nucleotide polymorphisms (SNPs) of IFNG and CLEC5A, to clarify the role of these factors in early response after vaccination. Activation of CLEC5A+ monocytes occurred five days after vaccination (DAV). Following, seven DAV data showed activation of CD4+ and CD8+T cells together with early positive correlations between type II IFN and genes of innate antiviral response (STAT1, STAT2, IRF7, IRF9, OAS1, and RNASEL) as well as antibody levels. Furthermore, individuals with genotypes rs2430561 AT\/AA, rs2069718 AG\/AA (IFNG), and rs13237944 AC\/AA (CLEC5A), exhibited higher expression of IFNG and CLEC5A, respectively. Together, we demonstrated that early IFN-\u03b3 and CLEC5A responses, associated with rs2430561, rs2069718, and rs13237944 genotypes, may be key mechanisms in the long-lasting immunity elicited by YF17DD.<\/jats:p>","DOI":"10.3390\/v13010096","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T20:11:31Z","timestamp":1610482291000},"page":"96","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-\u03b3 and CLEC5A"],"prefix":"10.3390","volume":"13","author":[{"given":"Tamiris","family":"Azamor","sequence":"first","affiliation":[{"name":"Bio-Manguinhos\/Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"},{"name":"Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a Marques Vieira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Bio-Manguinhos\/Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0087-6531","authenticated-orcid":false,"given":"Juliana Gil","family":"Melga\u00e7o","sequence":"additional","affiliation":[{"name":"Bio-Manguinhos\/Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Bio-Manguinhos\/Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Xavier-Carvalho","sequence":"additional","affiliation":[{"name":"Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Elena","family":"Alvarado-Arnez","sequence":"additional","affiliation":[{"name":"National Research Coordination, Universidad Privada Franz Tamayo, Cochabamba 4780, Bolivia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Ribeiro","family":"Batista-Silva","sequence":"additional","affiliation":[{"name":"Molecular Carcinogenesis Program\u2014Research Coordination, Instituto Nacional do C\u00e2ncer, Rio de Janeiro 20231-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-5776","authenticated-orcid":false,"given":"Denise Cristina","family":"de Souza Matos","sequence":"additional","affiliation":[{"name":"Bio-Manguinhos\/Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Bayma","sequence":"additional","affiliation":[{"name":"Bio-Manguinhos\/Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotiris","family":"Missailidis","sequence":"additional","affiliation":[{"name":"Bio-Manguinhos\/Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Dinis","family":"Ano Bom","sequence":"additional","affiliation":[{"name":"Bio-Manguinhos\/Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton Ozorio","family":"Moraes","sequence":"additional","affiliation":[{"name":"Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-9354","authenticated-orcid":false,"given":"Patr\u00edcia Cristina","family":"da Costa Neves","sequence":"additional","affiliation":[{"name":"Bio-Manguinhos\/Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40794-020-0101-0","article-title":"Yellow Fever Control: Current Epidemiology and Vaccination Strategies","volume":"6","author":"Chen","year":"2020","journal-title":"Trop. 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