{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:57:52Z","timestamp":1777478272456,"version":"3.51.4"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Disease Control and Prevention Agency","award":["4800-4859-300"],"award-info":[{"award-number":["4800-4859-300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The risk of polio importation and re-emergence persists since epidemic polio still occurs in some countries, and the resurgence of polio occurring almost 20 years after polio eradication was declared in Asia has been reported. We analyzed the results of acute flaccid paralysis (AFP) surveillance in Korea to assess the quality of AFP surveillance and understand the etiology of non-polio enterovirus (NPEV)-associated central nervous system diseases in a polio-free area. We investigated 637 AFP patients under 15 years of age whose cases were confirmed during 2012\u20132019 by virus isolation, real-time reverse transcription polymerase chain reaction, and VP1 gene sequencing. Among the 637 AFP cases, NPEV was detected in 213 (33.4%) patients, with the majority observed in EV-A71, with 54.9% of NPEV positives. EV-A71 has been shown to play a role as a major causative agent in most neurological diseases except for Guillain-Barr\u00e9 syndrome (GBS), acute disseminated encephalomyelitis (ADEM), and meningitis. This study provides information on the AFP surveillance situation in Korea and highlights the polio eradication stage in the monitoring and characterization of NPEV against the outbreak of neurological infectious diseases such as polio.<\/jats:p>","DOI":"10.3390\/v13030411","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T01:59:28Z","timestamp":1614909568000},"page":"411","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Non-Polio Enteroviruses from Acute Flaccid Paralysis Surveillance in Korea, 2012\u20132019"],"prefix":"10.3390","volume":"13","author":[{"given":"Youngsil","family":"Yoon","sequence":"first","affiliation":[{"name":"Division of Viral Diseases, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Pyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Diagnosis Control, Regional Centers for Disease Control and Prevention, Korea~Disease Control and Prevention Agency, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deog-Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Vaccine Clinical Research, National Institute of Health, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wooyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Diagnosis Control, Regional Centers for Disease Control and Prevention, Korea~Disease Control and Prevention Agency, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong Hyun","family":"Bin","sequence":"additional","affiliation":[{"name":"College of Medicine, Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-6911","authenticated-orcid":false,"given":"Young Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Medicine, Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung-Guk","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae Ji","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18295\/squmj.2020.20.01.001","article-title":"Wild Poliovirus Type 1 in Oman: A re-emerging threat that requires urgent, targeted and strategic preparedness","volume":"20","author":"Khamis","year":"2020","journal-title":"Sultan Qaboos Univ. 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