{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T03:48:50Z","timestamp":1785728930309,"version":"3.56.0"},"reference-count":16,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Agency Poland","award":["2020\/ABM\/Covid-19\/0005"],"award-info":[{"award-number":["2020\/ABM\/Covid-19\/0005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The use of convalescent plasma in the treatment of COVID-19 may lead to a milder course of infection and has been associated with improved outcomes. Determining optimal treatments in high risk populations is crucial, as is the case in those with hematological malignancies. We analyzed a cohort of 23 patients with hematological malignancies and COVID-19 who had received plasma 48\u201372 h after the diagnosis of infection and compared it with a historical group of 22 patients who received other therapy. Overall survival in those who received convalescent plasma was significantly higher than in the historical group (p = 0.03460). The plasma\u2013treated group also showed a significantly milder course of infection (p = 0.03807), characterized by less severe symptoms and faster recovery (p = 0.00001). In conclusion, we have demonstrated that convalescent plasma is an effective treatment and its early administration leads to clinical improvement, increased viral clearance and longer overall survival in patients with hematological malignancies and COVID-19. To our knowledge, this is the first report to analyze the efficacy of convalescent plasma in a cohort of patients with hematological malignancies.<\/jats:p>","DOI":"10.3390\/v13030436","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T23:04:39Z","timestamp":1615244679000},"page":"436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Early Administration of Convalescent Plasma Improves Survival in Patients with Hematological Malignancies and COVID-19"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-3398","authenticated-orcid":false,"given":"Monika Maria","family":"Biernat","sequence":"first","affiliation":[{"name":"Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kolasi\u0144ska","sequence":"additional","affiliation":[{"name":"Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-4251","authenticated-orcid":false,"given":"Jacek","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donata","family":"Urbaniak-Kujda","sequence":"additional","affiliation":[{"name":"Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Biernat","sequence":"additional","affiliation":[{"name":"Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-4559","authenticated-orcid":false,"given":"Justyna","family":"Janocha-Litwin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology, Wroclaw Medical University, Koszarowa Street 5, 51-149 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Szymczyk-Nu\u017cka","sequence":"additional","affiliation":[{"name":"Regional Centre of Transfusion Medicine and Blood Bank (RCTMBB-W), Czerwonego Krzy\u017ca Street 5\/9, 50-345 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawid","family":"Bursy","sequence":"additional","affiliation":[{"name":"Department of Drugs Form Technology, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Kalici\u0144ska","sequence":"additional","affiliation":[{"name":"Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-0412","authenticated-orcid":false,"given":"Krzysztof","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology, Wroclaw Medical University, Koszarowa Street 5, 51-149 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6610-2008","authenticated-orcid":false,"given":"Grzegorz","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department and Clinic of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-3535","authenticated-orcid":false,"given":"Tomasz","family":"Wr\u00f3bel","sequence":"additional","affiliation":[{"name":"Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Pasteura Street 4, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104574","DOI":"10.1016\/j.jcv.2020.104574","article-title":"Nosocomial outbreak of SARS-CoV-2 infection in a haematological unit-High mortality rate in infected patients with haematologic malignancies","volume":"130","author":"Biernat","year":"2020","journal-title":"J. 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