{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:15:27Z","timestamp":1787030127164,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/08578-0"],"award-info":[{"award-number":["2016\/08578-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Congenital Zika virus (ZIKV) infection may present with a broad spectrum of clinical manifestations. Some sequelae, particularly neurodevelopmental problems, may have a later onset. We conducted a prospective cohort study of 799 high-risk pregnant women who were followed up until delivery. Eighty-three women and\/or newborns were considered ZIKV exposed and\/or infected. Laboratory diagnosis was made by polymerase chain reaction in the pregnant mothers and their respective newborns, as well as Dengue virus, Chikungunya virus, and ZIKV serology. Serology for toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, and syphilis infections were also performed in microcephalic newborns. The newborns included in the study were followed up until their third birthday. Developmental delay was observed in nine patients (13.2%): mild cognitive delay in three patients, speech delay in three patients, autism spectrum disorder in two patients, and severe neurological abnormalities in one microcephalic patient; sensorineural hearing loss, three patients and dysphagia, six patients. Microcephaly due to ZIKV occurred in three patients (3.6%). Clinical manifestations can appear after the first year of life in children infected\/exposed to ZIKV, emphasizing the need for long-term follow-up.<\/jats:p>","DOI":"10.3390\/v13030523","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T12:55:07Z","timestamp":1616417707000},"page":"523","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2527-9880","authenticated-orcid":false,"given":"Rosa Estela","family":"Gazeta","sequence":"first","affiliation":[{"name":"Pediatrics Department, Jundia\u00ed Medical School, Jundia\u00ed 13202-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Antunes Pascalicchio","family":"Bertozzi","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Jundia\u00ed Medical School, Jundia\u00ed 13202-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9096-6308","authenticated-orcid":false,"given":"Rita de C\u00e1ssia de Aguirre Bernardes","family":"Dezena","sequence":"additional","affiliation":[{"name":"University Center Campo Limpo Paulista-UNIFACCAMP, Campo Limpo Paulista, S\u00e3o Paulo 13231-230, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Cristina Botelho","family":"Silva","sequence":"additional","affiliation":[{"name":"Pediatric Infectology Laboratory, Jundia\u00ed Medical School, Jundia\u00ed 13202-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamirys Cosmo Gillo","family":"Fajardo","sequence":"additional","affiliation":[{"name":"Pediatric Infectology Laboratory, Jundia\u00ed Medical School, Jundia\u00ed 13202-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1898-8339","authenticated-orcid":false,"given":"Daniel T.","family":"Catalan","sequence":"additional","affiliation":[{"name":"Pediatric Infectology Laboratory, Jundia\u00ed Medical School, Jundia\u00ed 13202-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de F\u00e1tima Valente","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Jundia\u00ed Medical School, Jundia\u00ed 13202-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Fernandes","family":"Moron","sequence":"additional","affiliation":[{"name":"Tropical Medicine Institute, Campus S\u00e3o Paulo, University of S\u00e3o Paulo (USP), S\u00e3o Paulo 05403-000, 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Emergency Department, Pediatrics Department -Pontif\u00edcia Universidade Cat\u00f3lica de Campinas, Campinas 13086900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7616-4031","authenticated-orcid":false,"given":"Dora Fix","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology, Institute of Psychology, Campus S\u00e3o Paulo, University of S\u00e3o Paulo, S\u00e3o Paulo 05588-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Max","family":"Damico","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology, Institute of Psychology, Campus S\u00e3o Paulo, University of S\u00e3o Paulo, S\u00e3o Paulo 05588-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valtenice de Cassia Rodrigues de Matos","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Experimental 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