{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:05:54Z","timestamp":1784552754219,"version":"3.55.0"},"reference-count":27,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>(1) Background: Thailand has made significant progress in reducing the number of human and animal rabies cases. However, control and elimination of the last remaining pockets of dog-mediated rabies have shown to be burdensome, predominantly as a result of the large numbers of free-roaming dogs without an owner that cannot be restrained without special efforts and therefore remain unvaccinated. To reach these dogs, the feasibility, and benefits of oral rabies vaccination (ORV) as a complementary tool has been examined under field conditions. (2) Methods: ORV of dogs was tested in five study areas of four provinces in Thailand. In these areas, sites with free-roaming dogs were identified with the support of local municipal workers and dog caretakers. ORV teams visited each of five study areas and distributed rabies vaccine (SPBN GASGAS) in three bait formats that were offered to the dogs using a hand-out and retrieval model. The three bait types tested included: egg-flavored baits, egg-flavored baits pasted with commercially available cat liquid snack, and boiled-intestine baits. A dog offered a vaccine bait was considered vaccinated when the discarded sachet was perforated or if a dog chewed vaccine bait at least 5 times before it swallowed the bait, including the sachet. (3) Results: A total of 2444 free-roaming dogs considered inaccessible for parenteral vaccination were identified at 338 sites. As not all dogs were approachable, 79.0% were offered a bait; of these dogs, 91.6% accepted the bait and subsequently 83.0% were considered successfully vaccinated. (4) Conclusion: Overall, 65.6% of the free-roaming dogs at these sites were successfully vaccinated by the oral route. Such a significant increase of the vaccination coverage of the free-roaming dog population could interrupt the rabies transmission cycle and offers a unique opportunity to reach the goal to eliminate dog-mediated human rabies in Thailand by 2030.<\/jats:p>","DOI":"10.3390\/v13040571","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T16:01:57Z","timestamp":1617033717000},"page":"571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Feasibility and Effectiveness Studies with Oral Vaccination of Free-Roaming Dogs against Rabies in Thailand"],"prefix":"10.3390","volume":"13","author":[{"given":"Karoon","family":"Chanachai","sequence":"first","affiliation":[{"name":"USAID Regional Development Mission Asia (Former at the Department of Livestock Development, Thailand), Athenee Tower, 25th Floor, 63 Wireless Road, Lumpini, Patumwan, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilaiporn","family":"Wongphruksasoong","sequence":"additional","affiliation":[{"name":"Department of Livestock Development, Ministry of Agriculture, Ratchathewi, Bangok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad","family":"Vos","sequence":"additional","affiliation":[{"name":"CEVA Innovation Center GmbH, Am Pharmapark, 06861 Dessau-Rosslau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6101-5191","authenticated-orcid":false,"given":"Kansuda","family":"Leelahapongsathon","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen 73140, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratanaporn","family":"Tangwangvivat","sequence":"additional","affiliation":[{"name":"Department of Disease Control, Ministry of Public Health, 88\/21 Tiwanon Rd., Talard-Kwan, Nonthaburi 11000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onpawee","family":"Sagarasaeranee","sequence":"additional","affiliation":[{"name":"Department of Livestock Development, Ministry of Agriculture, Ratchathewi, Bangok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3228-9542","authenticated-orcid":false,"given":"Paisin","family":"Lekcharoen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Chulalongkorn University, 39 Henri-Dunant Rd., Wangmai, Pathumwan, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Porathip","family":"Trinuson","sequence":"additional","affiliation":[{"name":"Department of Livestock Development, Ministry of Agriculture, Ratchathewi, Bangok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-6514","authenticated-orcid":false,"given":"Suwicha","family":"Kasemsuwan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen 73140, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2018). 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