{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:48:39Z","timestamp":1760402919847,"version":"build-2065373602"},"reference-count":72,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302677\/2019-4"],"award-info":[{"award-number":["302677\/2019-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/12944-9; 2017\/00021-9 and 2019\/21706-5)"],"award-info":[{"award-number":["2015\/12944-9; 2017\/00021-9 and 2019\/21706-5)"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Echoviruses (E) are a diverse group of viruses responsible for various pathological conditions in humans including aseptic meningitis, myocarditis, and acute flaccid paralysis. The detection and identification of echovirus genotypes in clinical samples is challenging due to its high genetic diversity. Here, we report the complete genome sequences of nine echoviruses, obtained by next-generation sequencing of 238 fecal samples from individuals with gastroenteritis in regions of Brazil. Detected viruses were classified into six genotypes: Three E1 sequences (BRA\/TO-028, BRA\/TO-069 and BRA\/TO-236), one E3 (BRA\/TO-018), one E11 (BRA\/TO-086), one E20 (BRA\/TO-016), two E29 (BRA\/TO-030 and BRA\/TO-193), and one E30 sequence (BRA\/TO-032). Phylogenetic analysis indicated that the echoviruses E1 and E29 circulating in Brazil are divergent from strains circulating worldwide. The genotype diversity identified in our study may under-represent the total echovirus diversity in Brazil because of the small sample size and the restricted geographical distribution covered by the survey.<\/jats:p>","DOI":"10.3390\/v13040595","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T10:24:33Z","timestamp":1617186273000},"page":"595","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["High Heterogeneity of Echoviruses in Brazilian Children with Acute Gastroenteritis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-896X","authenticated-orcid":false,"given":"Endrya","family":"do Socorro F\u00f4ro Ramos","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Diversidade Viral, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Par\u00e1, Belem 66075-000, Par\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulisses Alves","family":"Rosa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diversidade Viral, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Par\u00e1, Belem 66075-000, Par\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-7803","authenticated-orcid":false,"given":"Geovani","family":"de Oliveira Ribeiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diversidade Viral, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Par\u00e1, Belem 66075-000, Par\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4442-5855","authenticated-orcid":false,"given":"Fabiola","family":"Villanova","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diversidade Viral, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Par\u00e1, Belem 66075-000, Par\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio Augusto","family":"de P\u00e1dua Milagres","sequence":"additional","affiliation":[{"name":"Secretaria de Sa\u00fade do Tocantins, Palmas 77453-000, Tocantins, Brazil"},{"name":"Laborat\u00f3rio Central de Sa\u00fade P\u00fablica do Tocantins (LACEN\/TO), Palmas 77016-330, Tocantins, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Brustulin","sequence":"additional","affiliation":[{"name":"Secretaria de Sa\u00fade do Tocantins, Palmas 77453-000, Tocantins, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3813-3154","authenticated-orcid":false,"given":"Vanessa","family":"dos Santos Morais","sequence":"additional","affiliation":[{"name":"Departamento de Mol\u00e9stias Infecciosas e Parasit\u00e1rias, Instituto de Medicina Tropical, Faculdade de 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Lima","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"General Coordination of Public Health Laboratories of the Strategic Articulation, Department of the Health Surveillance Secretariat of the Ministry of Health (CGLAB\/DAEVS\/SVS-MS), Bras\u00edlia 70719-040, Federal District, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Witkin","sequence":"additional","affiliation":[{"name":"Departamento de Mol\u00e9stias Infecciosas e Parasit\u00e1rias, Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Department of Obstetrics and Gynecology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-4484","authenticated-orcid":false,"given":"Eric","family":"Delwart","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute, 270 Masonic Avenue, San Francisco, CA 94143, USA"},{"name":"Department Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Luchs","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Doen\u00e7as Ent\u00e9ricas, Centro de Virologia, Instituto Adolfo Lutz, S\u00e3o Paulo 01246-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-5177","authenticated-orcid":false,"given":"Antonio Charlys","family":"da Costa","sequence":"additional","affiliation":[{"name":"Departamento de Mol\u00e9stias Infecciosas e Parasit\u00e1rias, Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-0492","authenticated-orcid":false,"given":"\u00c9lcio","family":"Leal","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diversidade Viral, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Par\u00e1, Belem 66075-000, Par\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"ref_1","unstructured":"(2020, November 10). 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