{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:45:26Z","timestamp":1793191526762,"version":"4.5.0"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 under ZikaPLAN","award":["734584"],"award-info":[{"award-number":["734584"]}]},{"name":"Wellcome Trust &amp; the UK Department for International Development","award":["201870\/Z\/16\/Z"],"award-info":[{"award-number":["201870\/Z\/16\/Z"]}]},{"name":"Wellcome Trust &amp; the UK Department for International Development","award":["205377\/Z\/16\/Z"],"award-info":[{"award-number":["205377\/Z\/16\/Z"]}]},{"name":"Wellcome Trust - Research Enrichment in Epidemic Situations","award":["107779\/Z\/15\/Z, with ER1505 & ER1601"],"award-info":[{"award-number":["107779\/Z\/15\/Z, with ER1505 & ER1601"]}]},{"name":"Medical Research Council on behalf of the Newton Fund and Wellcome Trust","award":["MC_PC_15088"],"award-info":[{"award-number":["MC_PC_15088"]}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["APQ-0192-4.01\/17"],"award-info":[{"award-number":["APQ-0192-4.01\/17"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["APQ-0172-4.01\/16"],"award-info":[{"award-number":["APQ-0172-4.01\/16"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["309722\/2017-9"],"award-info":[{"award-number":["309722\/2017-9"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["306708\/2014-0"],"award-info":[{"award-number":["306708\/2014-0"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Minist\u00e9rio da Sa\u00fade do Brasil","award":["837058\/2016"],"award-info":[{"award-number":["837058\/2016"]}]},{"name":"Departamento de Ci\u00eancia e Tecnologia","award":["440839\/2016-5"],"award-info":[{"award-number":["440839\/2016-5"]}]},{"name":"National Institute of Child Health and Human Development (NICHD), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Environmental Health Sciences (NIEHS) and Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz","award":["HHSN275201800001I"],"award-info":[{"award-number":["HHSN275201800001I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>This cohort profile aims to describe the ongoing follow-up of children in the Microcephaly Epidemic Research Group Paediatric Cohort (MERG\u2013PC). The profile details the context and aims of the study, study population, methodology including assessments, and key results and publications to date. The children that make up MERG\u2013PC were born in Recife or within 120 km of the city, in Pernambuco\/Brazil, the epicentre of the microcephaly epidemic. MERG\u2013PC includes children from four groups recruited at different stages of the ZIKV microcephaly epidemic in Pernambuco, i.e., the Outpatient Group (OG\/n = 195), the Microcephaly Case\u2013Control Study (MCCS\/n = 80), the MERG Pregnant Women Cohort (MERG-PWC\/n = 336), and the Control Group (CG\/n = 100). We developed a comprehensive array of clinical, laboratory, and imaging assessments that were undertaken by a \u2018task force\u2019 of clinical specialists in a single day at 3, 6, 12, 18 months of age, and annually from 24 months. Children from MCCS and CG had their baseline assessment at birth and children from the other groups, at the first evaluation by the task force. The baseline cohort includes 711 children born between February 2015 and February 2019. Children\u2019s characteristics at baseline, excluding CG, were as follows: 32.6% (184\/565) had microcephaly, 47% (263\/559) had at least one physical abnormality, 29.5% (160\/543) had at least one neurological abnormality, and 46.2% (257\/556) had at least one ophthalmological abnormality. This ongoing cohort has contributed to the understanding of the congenital Zika syndrome (CZS) spectrum. The cohort has provided descriptions of paediatric neurodevelopment and early epilepsy, including EEG patterns and treatment response, and information on the frequency and characteristics of oropharyngeal dysphagia; cryptorchidism and its surgical findings; endocrine dysfunction; and adenoid hypertrophy in children with Zika-related microcephaly. The study protocols and questionnaires were shared across Brazilian states to enable harmonization across the different studies investigating microcephaly and CZS, providing the opportunity for the Zika Brazilian Cohorts Consortium to be formed, uniting all the ZIKV clinical cohorts in Brazil.<\/jats:p>","DOI":"10.3390\/v13040602","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T10:44:01Z","timestamp":1617273841000},"page":"602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Microcephaly Epidemic Research Group Paediatric Cohort (MERG\u2013PC): A Cohort Profile"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-1476","authenticated-orcid":false,"given":"Dem\u00f3crito","family":"de Barros Miranda-Filho","sequence":"first","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-2288","authenticated-orcid":false,"given":"Elizabeth","family":"Brickley","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ramond","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2491-0688","authenticated-orcid":false,"given":"Celina","family":"Martelli","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es\u2014Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Recife 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2048-5079","authenticated-orcid":false,"given":"Nuria","family":"Sanchez Clemente","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e1lia","family":"Velho Barreto de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Social, Universidade Federal de Pernambuco, Recife 50670-420, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-5693","authenticated-orcid":false,"given":"Ulisses","family":"Montarroyos","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-9332","authenticated-orcid":false,"given":"Wayner","family":"de Souza","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es\u2014Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Recife 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es\u2014Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Recife 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Ventura","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmologia, Funda\u00e7\u00e3o Altino Ventura, Recife 52171-011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Marques","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es\u2014Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Recife 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Leal","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia, Universidade Federal de Pernambuco, Recife 50670-420, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-2107","authenticated-orcid":false,"given":"Sophie","family":"Eickmann","sequence":"additional","affiliation":[{"name":"Departamento Materno-Infantil, Universidade Federal de Pernambuco, Recife 50670-420, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Wanderley Rocha","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Oswaldo Cruz, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-4732","authenticated-orcid":false,"given":"Paula","family":"Sobral da Silva","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-010, Brazil"},{"name":"Hospital Universit\u00e1rio Oswaldo Cruz, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gomes Carvalho","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-010, Brazil"},{"name":"Hospital Universit\u00e1rio Oswaldo Cruz, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Ramos","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Oswaldo Cruz, Recife 50100-130, Brazil"},{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3933-430X","authenticated-orcid":false,"given":"Danielle","family":"da Silva Oliveira","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-010, Brazil"},{"name":"Hospital Universit\u00e1rio Oswaldo Cruz, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgana","family":"Xavier","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es\u2014Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Recife 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-2099","authenticated-orcid":false,"given":"R\u00f4mulo","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-010, Brazil"},{"name":"Hospital Universit\u00e1rio Oswaldo Cruz, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia","family":"Veras Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Oswaldo Cruz, Recife 50100-130, Brazil"},{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Brainer","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-010, Brazil"},{"name":"Hospital Universit\u00e1rio Oswaldo Cruz, Recife 50100-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marli","family":"Ten\u00f3rio Cordeiro","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es\u2014Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Recife 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Arraes de Alencar Ximenes","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Recife 50100-010, Brazil"},{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Microcephaly Epidemic Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"ref_1","unstructured":"(2020, December 05). Minist\u00e9rio da Sa\u00fade Confirma Rela\u00e7\u00e3o Entre V\u00edrus Zika e Microcefalia, Available online: http:\/\/www.blog.saude.gov.br\/index.php\/combate-ao-aedes\/50399-ministerio-da-saude-confirma-relacao-entre-virus-zika-e-microcefalia."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2471\/BLT.16.178608","article-title":"Risk of Microcephaly after Zika Virus Infection in Brazil, 2015 to 2016","volume":"95","author":"Jaenisch","year":"2017","journal-title":"Bull. World Health Organ."},{"key":"ref_3","unstructured":"(2020, December 05). MERG\u2014Grupo de Pesquisa da Epidemia de Microcefalia. Available online: http:\/\/scf.cpqam.fiocruz.br\/merg\/index.php."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S1473-3099(16)30318-8","article-title":"Association between Zika Virus Infection and Microcephaly in Brazil, January to May, 2016: Preliminary Report of a Case-Control Study","volume":"16","author":"Rodrigues","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S1473-3099(17)30727-2","article-title":"Association between Microcephaly, Zika Virus Infection, and Other Risk Factors in Brazil: Final Report of a Case-Control Study","volume":"18","author":"Ximenes","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_6","unstructured":"(2020, December 05). Informa\u00e7\u00f5es de Sa\u00fade: Popula\u00e7\u00e3o Residente\u2014Pernambuco, Available online: http:\/\/tabnet.datasus.gov.br\/cgi\/deftohtm.exe?ibge\/cnv\/poppe.def."},{"key":"ref_7","unstructured":"(2020, December 05). Clima: Pernambuco. Available online: https:\/\/pt.climate-data.org\/america-do-sul\/brasil\/pernambuco-211\/."},{"key":"ref_8","unstructured":"(2020, December 05). Instituto Brasileiro de Geografia e Estat\u00edstica: IBGE Cidades, Available online: https:\/\/cidades.ibge.gov.br\/brasil\/pe\/recife\/panorama."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ximenes, R.A.A., Miranda-Filho, D.B., Brickley, E.B., Montarroyos, U.R., Martelli, C.M.T., Ara\u00fajo, T.V.B., Rodrigues, L.C., Albuquerque, M.D.F.P.M., Souza, W.V., and Castanha, P.M.D.S. (2019). Zika Virus Infection in Pregnancy: Establishing a Case Definition for Clinical Research on Pregnant Women with Rash in an Active Transmission Setting. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007763"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lebov, J.F., Arias, J.F., Balmaseda, A., Britt, W., Cordero, J.F., Galv\u00e3o, L.A., Garces, A.L., Hambidge, K.M., Harris, E., and Ko, A. (2019). International Prospective Observational Cohort Study of Zika in Infants and Pregnancy (ZIP Study): Study Protocol. BMC Pregnancy Childbirth, 19.","DOI":"10.1186\/s12884-019-2589-8"},{"key":"ref_11","unstructured":"(2020, December 05). World Health Organization: Child Growth Standards. Available online: https:\/\/www.who.int\/tools\/child-growth-standards."},{"key":"ref_12","unstructured":"(2020, December 05). INTERGROWTH-21st. Available online: http:\/\/intergrowth21.ndog.ox.ac.uk\/."},{"key":"ref_13","unstructured":"(2020, December 05). Protocolo de Vigil\u00e2ncia e Resposta \u00e0 Ocorr\u00eancia de Microcefalia e\/ou Altera\u00e7\u00f5es do Sistema Nervoso Central (SNC), Available online: http:\/\/portalarquivos.saude.gov.br\/images\/pdf\/2016\/marco\/24\/Microcefalia-Protocolo-vigil--ncia-resposta-versao2.1.pdf."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Fenton, T.R., and Kim, J.H. (2013). A Systematic Review and Meta-Analysis to Revise the Fenton Growth Chart for Preterm Infants. BMC Pediatr., 13.","DOI":"10.1186\/1471-2431-13-59"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(14)60932-6","article-title":"International Standards for Newborn Weight, Length, and Head Circumference by Gestational Age and Sex: The Newborn Cross-Sectional Study of the INTERGROWTH-21st Project","volume":"384","author":"Villar","year":"2014","journal-title":"Lancet"},{"key":"ref_16","unstructured":"(2020, December 05). INTERGROWTH-21st Newborn Size at Birth Chart. Available online: https:\/\/intergrowth21.tghn.org\/articles\/intergrowth-21st-newborn-size-birth-chart\/."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.acap.2013.07.001","article-title":"Evidence-Based Milestones for Surveillance of Cognitive, Language, and Motor Development","volume":"13","author":"Sheldrick","year":"2013","journal-title":"Acad. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Oliveira, D.M.S., Miranda-Filho, D.B., Ximenes, R.A.A., Montarroyos, U.R., Martelli, C.M.T., Brickley, E.B., Gouveia, M.C.L., Ramos, R.C., Rocha, M.A.W., and Araujo, T.V.B. (2020). Comparison of Oropharyngeal Dysphagia in Brazilian Children with Prenatal Exposure to Zika Virus, With and Without Microcephaly. Dysphagia, Online ahead of print.","DOI":"10.1007\/s00455-020-10173-4"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ximenes, R.A.A., Miranda-Filho, D.B., Montarroyos, U.R., Martelli, C.M.T., Ara\u00fajo, T.V.B., Brickley, E., Albuquerque, M.F.P.M., Souza, W.V., Ventura, L., and Ventura, C. (2021). Zika Related Adverse Outcomes in a Cohort of Pregnant Women with Rash in Pernambuco, Brazil. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009216"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Microcephaly Epidemic Research Group (2016). Microcephaly in Infants, Pernambuco State, Brazil, 2015. Emerg. Infect. Dis., 22, 1090\u20131093.","DOI":"10.3201\/eid2206.160062"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.clinph.2016.11.004","article-title":"Sleep EEG Patterns in Infants with Congenital Zika Virus Syndrome","volume":"128","author":"Carvalho","year":"2017","journal-title":"Clin. Neurophysiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/epi.16444","article-title":"Early Epilepsy in Children with Zika-Related Microcephaly in a Cohort in Recife, Brazil: Characteristics, Electroencephalographic Findings, and Treatment Response","volume":"61","author":"Carvalho","year":"2020","journal-title":"Epilepsia"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Silva, P.F.S., Eickmann, S.H., Ximenes, R.A.A., Montarroyos, U.R., Lima, M.C., Martelli, C.M.T., Ara\u00fajo, T.V.B., Brickley, E.B., Rodrigues, L.C., and Gon\u00e7alves, F.C.L.D.S.P. (2020). Pediatric Neurodevelopment by Prenatal Zika Virus Exposure: A Cross-Sectional Study of the Microcephaly Epidemic Research Group Cohort. BMC Pediatr., 20.","DOI":"10.1186\/s12887-020-02331-2"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"982","DOI":"10.4269\/ajtmh.19-0753","article-title":"Cryptorchidism in Children with Zika-Related Microcephaly","volume":"102","author":"Vasconcelos","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Vasconcelos, R.A.L., Ximenes, R.A.A., Calado, A.A., Martelli, C.M.T., Gon\u00e7alves, A.V., Brickley, E.B., Ara\u00fajo, T.V.B., Rocha, M.A.W., and Miranda-Filho, D.B. (2020). Surgical Findings in Cryptorchidism in Children with Zika-Related Microcephaly: A Case Series. BMC Urol., 20.","DOI":"10.1186\/s12894-020-00721-3"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves, A.V., Miranda-Filho, D.B., Vilela, L.C.R., Ramos, R.C.F., Ara\u00fajo, T.V.B., Vasconcelos, R.A.L., Rocha, M.A.W., Eickmann, S.H., Cordeiro, M.T., and Ventura, M.L.V.O. (2020). Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil. Viruses, 13.","DOI":"10.3390\/v13010001"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Leal, M.C., Ramos, D.S., Bezerra, T.P., Vilela, A.E.S.C., de Maciel, R.J.F., Rodrigues, M., Lira, M., de Cavalcanti, K.P.S., Van der Linden, V., and Cordeiro, M.T. (2021). The Prevalence of Adenoid Hypertrophy among Children with Zika Related Microcephaly. Viruses, 13.","DOI":"10.3390\/v13010062"},{"key":"ref_28","unstructured":"Zika Brazilian Cohorts Consortium Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an individual participant data meta-analysis of Congenital Zika Syndrome after maternal exposure during pregnancy. Viruses, Accepted work."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/4\/602\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:10:55Z","timestamp":1760364655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/4\/602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["v13040602"],"URL":"https:\/\/doi.org\/10.3390\/v13040602","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]}}}