{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:20:41Z","timestamp":1773339641793,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["PPSUS and DECIT [TED 51\/2019]"],"award-info":[{"award-number":["PPSUS and DECIT [TED 51\/2019]"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["400911\/2018-3n"],"award-info":[{"award-number":["400911\/2018-3n"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The purpose of this paper is to describe the hematological profile of pregnant women with suspected Zika virus (ZIKV) infection followed up at a reference service for infectious diseases in Manaus, Brazil, through a clinical, epidemiological, cross-sectional study of pregnant women with an exanthematic manifestation who looked for care between 2015 and 2017. The participants were 499 pregnant women, classified into four subgroups, according to laboratory confirmation of infections: ZIKV-positive; ZIKV-positive and positive for another infection; positive for another infection but not ZIKV-positive; and not positive for any of the infections investigated. Hematological parameters were analyzed descriptively. The association between maternal infection and the hematological profile, along with the association between the maternal hematological profile and the gestational outcome, were tested. Similar hematic and platelet parameters were observed among pregnant women. However, a significant association was observed between low maternal lymphocyte count and a positive diagnosis for ZIKV (p &lt; 0.001). The increase in maternal platelet count and the occurrence of unfavorable gestational outcome were positively associated. A similar hematic and platelet profile was identified among pregnant women, differing only in the low lymphocyte count among ZIKV-positive pregnant women. Regarding gestational outcomes, in addition to the damage caused by ZIKV infection, altered maternal platelets may lead to unfavorable outcomes, with the need for adequate follow-up during prenatal care.<\/jats:p>","DOI":"10.3390\/v13040710","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T01:41:25Z","timestamp":1618882885000},"page":"710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hematological Profile of Pregnant Women with Suspected Zika Virus Infection Followed Up at a Referral Service in Manaus, Brazil"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7041-620X","authenticated-orcid":false,"given":"Anny Beatriz Costa Antony de","family":"Andrade","sequence":"first","affiliation":[{"name":"Oswaldo Cruz Foundation, Le\u00f4nidas &amp; Maria Deane Institute, Amazonas 69057-070, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jacirema Ferreira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Nursing College, Federal University of Amazonas, Amazonas 69057-070, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elijane de F\u00e1tima","family":"Redivo","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Amazonas 69040-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria das Gra\u00e7as Costa","family":"Alecrim","sequence":"additional","affiliation":[{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Amazonas 69040-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0325-3674","authenticated-orcid":false,"given":"Flor Ernestina","family":"Martinez-Espinosa","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation, Le\u00f4nidas &amp; Maria Deane Institute, Amazonas 69057-070, Brazil"},{"name":"Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Amazonas 69040-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"ref_1","unstructured":"WHO (2019, April 24). 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