{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:44:28Z","timestamp":1790502268195,"version":"4.1.0"},"reference-count":58,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa de Excel\u00eancia em Pesquisa (PROEP) - CNPq\/Instituto Aggeu Magalh\u00e3es-FIOCRUZ","award":["400757\/2019-2"],"award-info":[{"award-number":["400757\/2019-2"]}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["scholarship IBPG-1761-4.06\/16"],"award-info":[{"award-number":["scholarship IBPG-1761-4.06\/16"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The diagnostic of arbovirus-related obstetric complications in high-risk pregnancy and childbirth care is challenging, especially in endemic areas. We conducted a prospective study to track active or recent Zika (ZIKV), dengue (DENV), or chikungunya (CHIKV) virus infection among hospitalized pregnant women (PW) with obstetric complications in a hospital at the epicenter of Zika outbreak and ZIKV-related microcephaly in Brazil. Clinical data and blood samples were collected at enrollment and 10 days after the admission of study participants, between October 2018 and May 2019. Further clinical data were extracted from medical records. Samples were screened by molecular and serological tests. Out of 780 participants, 93.1% (95% CI: 91.1\u201394.7%) presented previous DENV exposure (IgG). ZIKV, CHIKV, and\/or DENV laboratory markers of recent or active infection were detected in 130 PW, yielding a prevalence of 16.6% (95% CI: 14.2\u201319.5%); 9.4% (95% CI: 7.4\u201311.7%), 7.4% (95% CI: 5.7\u20139.7%), and 0.38% (95% CI: 0.1\u20131.2%) of CHIKV, ZIKV, and DENV infections, respectively. Most ZIKV infections were detected by molecular assays (89.6%), while CHIKV infections were detected by serology (95.9%). Our findings highlight the need for arbovirus infections screening in PW with obstetrical complications, potentially associated to these infections in endemic areas regardless of the signs or symptoms suggestive of arboviral disease.<\/jats:p>","DOI":"10.3390\/v13050744","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T02:12:57Z","timestamp":1619316777000},"page":"744","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["High Incidence of Zika or Chikungunya Infection among Pregnant Women Hospitalized Due to Obstetrical Complications in Northeastern Brazil\u2014Implications for Laboratory Screening in Arbovirus Endemic Area"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-2901","authenticated-orcid":false,"given":"Iracema J. A. A.","family":"Jacques","sequence":"first","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz Pernambuco, Recife CEP 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9854-7917","authenticated-orcid":false,"given":"Leila","family":"Katz","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernando Figueira, Recife CEP 50070-550, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-2140","authenticated-orcid":false,"given":"Mar\u00edlia A.","family":"Sena","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz Pernambuco, Recife CEP 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B. G.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz Pernambuco, Recife CEP 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmim L.","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz Pernambuco, Recife CEP 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-7851","authenticated-orcid":false,"given":"Gabriela D. M.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernando Figueira, Recife CEP 50070-550, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa O.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernando Figueira, Recife CEP 50070-550, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila A. M. C.","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernando Figueira, Recife CEP 50070-550, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Almerice L.","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz Pernambuco, Recife CEP 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A. S.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz Pernambuco, Recife CEP 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de F\u00e1tima P. M.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz Pernambuco, Recife CEP 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marli T.","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz Pernambuco, Recife CEP 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3826-9358","authenticated-orcid":false,"suffix":"Jr.","given":"Ernesto T. 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