{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:30:57Z","timestamp":1783042257909,"version":"3.54.6"},"reference-count":153,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Influenza is a highly known contagious viral infection that has been responsible for the death of many people in history with pandemics. These pandemics have been occurring every 10 to 30 years in the last century. The most recent global pandemic prior to COVID-19 was the 2009 influenza A (H1N1) pandemic. A decade ago, the H1N1 virus caused 12,500 deaths in just 19 months globally. Now, again, the world has been challenged with another pandemic. Since December 2019, the first case of a novel coronavirus (COVID-19) infection was detected in Wuhan. This infection has risen rapidly throughout the world; even the World Health Organization (WHO) announced COVID-19 as a worldwide emergency to ensure human health and public safety. This review article aims to discuss important issues relating to COVID-19, including clinical, epidemiological, and pathological features of COVID-19 and recent progress in diagnosis and treatment approaches for the COVID-19 infection. We also highlight key similarities and differences between COVID-19 and influenza A to ensure the theoretical and practical details of COVID-19.<\/jats:p>","DOI":"10.3390\/v13061145","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T21:24:29Z","timestamp":1623792269000},"page":"1145","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Progression and Trends in Virus from Influenza A to COVID-19: An Overview of Recent Studies"],"prefix":"10.3390","volume":"13","author":[{"given":"Hakimeh","family":"Daemi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9512-5230","authenticated-orcid":false,"given":"Muhammad","family":"Kulyar","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlin","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-3968","authenticated-orcid":false,"given":"Morteza","family":"Karimpour","sequence":"additional","affiliation":[{"name":"Department of Biology, Azad University of Rasht, Rasht 4147654919, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4332-4083","authenticated-orcid":false,"given":"Meilin","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.34172\/jrcm.2020.005","article-title":"Novel coronavirus (COVID-19): A new emerging pandemic threat","volume":"8","author":"Rezabakhsh","year":"2020","journal-title":"J. Res. Clin. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/1075547020953603","article-title":"Framing the Origins of COVID-19","volume":"42","author":"Bolsen","year":"2020","journal-title":"Sci. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bj.2020.04.007","article-title":"COVID-19: The first documented coronavirus pandemic in history","volume":"43","author":"Liu","year":"2020","journal-title":"Biomed. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.1073\/pnas.2004999117","article-title":"Phylogenetic network analysis of SARS-CoV-2 genomes","volume":"117","author":"Forster","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","first-page":"400","article-title":"Swine influenza A (H1N1) infection in two children\u2014Southern California, March\u2013April 2009","volume":"58","author":"Patient","year":"2009","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/S0140-6736(09)61638-X","article-title":"Infection and death from influenza A H1N1 virus in Mexico: A retrospective analysis","volume":"374","year":"2009","journal-title":"Lancet"},{"key":"ref_7","unstructured":"World Health Organization (2017). World Health Organization Weekly Epidemiological Record, World Health Organization."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Shao, W., Li, X., Goraya, M.U., Wang, S., and Chen, J.-L. (2017). Evolution of influenza a virus by mutation and re-assortment. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081650"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Huang, S.S.H., Banner, D., Fang, Y., Ng, D.C.K., Kanagasabai, T., Kelvin, D.J., and Kelvin, A.A. (2011). Comparative analyses of pandemic H1N1 and seasonal H1N1, H3N2, and influenza B infections depict distinct clinical pictures in ferrets. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027512"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.virusres.2018.10.001","article-title":"Molecular epidemiology of the hemagglutinin gene of prevalent influenza virus A\/H1N1\/pdm09 among patient in Iran","volume":"259","author":"Mohebbi","year":"2019","journal-title":"Virus Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.12968\/jpar.2020.12.4.136","article-title":"Distinguishing the novel coronavirus from influenza","volume":"12","author":"Higginson","year":"2020","journal-title":"J. Paramed. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s15010-020-01409-4","article-title":"Successful containment of COVID-19: The WHO-Report on the COVID-19 outbreak in China","volume":"48","author":"Salzberger","year":"2020","journal-title":"Infection"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Payne, S. (2017). Family Coronaviridae. Viruses, 149\u2013158.","DOI":"10.1016\/B978-0-12-803109-4.00017-9"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jmv.25681","article-title":"Emerging coronaviruses: Genome structure, replication, and pathogenesis","volume":"92","author":"Chen","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.molcel.2020.04.022","article-title":"A multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells","volume":"78","author":"Hoffmann","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.arcmed.2020.05.012","article-title":"Structural proteins in severe acute respiratory syndrome coronavirus-2","volume":"51","author":"Satarker","year":"2020","journal-title":"Arch. Med. Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mohammadi-Dehcheshmeh, M., Moghbeli, S.M., Rahimirad, S., Alanazi, I., Al Shehri, Z.S., and Ebrahimie, E. (2020). Achilles\u2019 heel of SARS-CoV-2: Transcription regulatory sequence and leader sequence in 5\u2019untranslated region have unique evolutionary patterns and are vital for virus replication in infected human cells. Preprints.","DOI":"10.20944\/preprints202009.0602.v1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.meegid.2011.02.021","article-title":"Pandemic (H1N1) 2009 virus revisited: An evolutionary retrospective","volume":"11","author":"Christman","year":"2011","journal-title":"Infect. Genet. Evol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316","article-title":"The pathology of influenza virus infections","volume":"3","author":"Taubenberger","year":"2008","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1128\/JVI.79.5.2814-2822.2005","article-title":"Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls","volume":"79","author":"Fouchier","year":"2005","journal-title":"J. Virol."},{"key":"ref_21","first-page":"25","article-title":"Colds and influenza: A review of diagnosis and conventional, botanical, and nutritional considerations","volume":"12","author":"Roxas","year":"2007","journal-title":"Altern. Med. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3390\/v4071144","article-title":"Influenza virus-mediated membrane fusion: Determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion","volume":"4","author":"Hamilton","year":"2012","journal-title":"Viruses"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101630","DOI":"10.1016\/j.tmaid.2020.101630","article-title":"Mapping the incidence of the COVID-19 hotspot in Iran\u2013Implications for Travellers","volume":"34","author":"Sah","year":"2020","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.pulmoe.2020.04.008","article-title":"COVID-19 in Brazil","volume":"26","author":"Marson","year":"2020","journal-title":"Pulmonology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"146408","DOI":"10.1016\/j.scitotenv.2021.146408","article-title":"COVID-19 containment on a college campus via wastewater-based epidemiology, targeted clinical testing and an intervention","volume":"779","author":"Betancourt","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"105924","DOI":"10.1016\/j.ijantimicag.2020.105924","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges","volume":"55","author":"Lai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Gorbalenya, A.E., Baker, S.C., Baric, R., de Groot, R.J., Drosten, C., Gulyaeva, A.A., Haagmans, B.L., Lauber, C., Leontovich, A.M., and Neuman, B.W. (2020). Severe acute respiratory syndrome-related coronavirus: The species and its viruses\u2014A statement of the Coronavirus Study Group. bioRxiv.","DOI":"10.1101\/2020.02.07.937862"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1473-3099(20)30243-7","article-title":"Estimates of the severity of coronavirus disease 2019: A model-based analysis","volume":"20","author":"Verity","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40249-020-00785-1","article-title":"COVID-19 case fatality risk by age and gender in a high testing setting in Latin America: Chile, March\u2013August 2020","volume":"10","author":"Undurraga","year":"2021","journal-title":"Infect. Dis. Poverty"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0140-6736(20)31748-7","article-title":"Sex differential in COVID-19 mortality varies markedly by age","volume":"396","author":"Bhopal","year":"2020","journal-title":"Lancet"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Guilmoto, C.Z.Z. (2020). COVID-19 death rates by age and sex and the resulting mortality vulnerability of countries and regions in the world. medRxiv.","DOI":"10.1101\/2020.05.17.20097410"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Scully, E.P., Schumock, G., Fu, M., Massaccesi, G., Muschelli, J., Betz, J., Klein, E.Y., West, N.E., Robinson, M., and Garibaldi, B.T. (2021). Sex and gender differences in COVID testing, hospital admission, presentation, and drivers of severe outcomes in the DC\/Maryland region. medRxiv.","DOI":"10.1101\/2021.04.05.21253827"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.abe7199","article-title":"Sex differences in immune responses: Biological sex differences in immunity potentially underlie male bias for severe COVID-19","volume":"371","author":"Takahashi","year":"2021","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-020-2521-4","article-title":"Factors associated with COVID-19-related death using OpenSAFELY","volume":"584","author":"Williamson","year":"2020","journal-title":"Nature"},{"key":"ref_35","first-page":"39","article-title":"High titers of hemagglutination inhibition antibodies against 2009 H1N1 influenza virus in Southern Iran","volume":"7","author":"Moghadami","year":"2010","journal-title":"Iran. J. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0042-6822(79)90189-2","article-title":"Analysis of antigenic drift in recently isolated influenza A (H1N1) viruses using monoclonal antibody preparations","volume":"96","author":"Webster","year":"1979","journal-title":"Virology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3201\/eid1201.051254","article-title":"Influenza pandemics of the 20th century","volume":"12","author":"Kilbourne","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature08157","article-title":"Emergence and pandemic potential of swine-origin H1N1 influenza virus","volume":"459","author":"Neumann","year":"2009","journal-title":"Nature"},{"key":"ref_39","first-page":"826","article-title":"Evaluation of rapid influenza diagnostic tests for detection of novel influenza A (H1N1) Virus-United States, 2009","volume":"58","author":"Balish","year":"2009","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1099\/vir.0.014480-0","article-title":"Pathogenesis and transmission of the novel swine-origin influenza virus A\/H1N1 after experimental infection of pigs","volume":"90","author":"Lange","year":"2009","journal-title":"J. Gen. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.rppneu.2012.01.006","article-title":"The 2009 pandemic influenza A (H1N1) virus infection: Experience of a paediatric service at a third-level hospital in Lisbon, Portugal","volume":"18","author":"Malveiro","year":"2012","journal-title":"Rev. Port. Pneumol. Engl. Ed."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jiph.2011.09.005","article-title":"Pandemic influenza A (2009 H1N1) in hospitalized patients in a Saudi Arabian hospital: Epidemiology and clinical comparison with H1N1-negative patients","volume":"4","author":"Abed","year":"2011","journal-title":"J. Infect. Public Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1750-2659.2009.00096.x","article-title":"Diversity of influenza viruses in swine and the emergence of a novel human pandemic influenza A (H1N1)","volume":"3","author":"Webster","year":"2009","journal-title":"Influenza Respir. Viruses"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1056\/NEJMoa0903810","article-title":"Novel swine-origin influenza A (H1N1) virus investigation team emergence of a novel swime origin-inf A (H1N1) virus in humans","volume":"360","author":"Hillyard","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Lemaitre, M., and Carrat, F. (2010). Comparative age distribution of influenza morbidity and mortality during seasonal influenza epidemics and the 2009 H1N1 pandemic. BMC Infect. Dis., 10.","DOI":"10.1186\/1471-2334-10-162"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1056\/NEJMoa051721","article-title":"Influenza-associated deaths among children in the United States, 2003\u20132004","volume":"353","author":"Bhat","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jcv.2013.09.004","article-title":"Age-specific and sex-specific morbidity and mortality from avian influenza A (H7N9)","volume":"58","author":"Dudley","year":"2013","journal-title":"J. Clin. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e23198","DOI":"10.1002\/ajhb.23198","article-title":"Sex-and age-based differences in mortality during the 1918 influenza pandemic on the island of Newfoundland","volume":"31","author":"Paskoff","year":"2019","journal-title":"Am. J. Hum. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1728-4457.2000.00565.x","article-title":"The 1918 influenza epidemic\u2019s effects on sex differentials in mortality in the United States","volume":"26","author":"Noymer","year":"2000","journal-title":"Popul. Dev. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4161\/hv.18911","article-title":"Pandemic influenza hospitalization in Spain (2009): Incidence, in-hospital mortality, comorbidities and costs","volume":"8","year":"2012","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Qian, Q., Fan, L., Liu, W., Li, J., Yue, J., Wang, M., Ke, X., Yin, Y., Chen, Q., and Jiang, C. (2020). Direct evidence of active SARS-CoV-2 replication in the intestine. Clin. Infect. Dis.","DOI":"10.1093\/cid\/ciaa925"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1001\/jama.2020.2565","article-title":"Presumed asymptomatic carrier transmission of COVID-19","volume":"323","author":"Bai","year":"2020","journal-title":"JAMA"},{"key":"ref_53","first-page":"668","article-title":"The epidemiological characteristics of infection in close contacts of COVID-19 in Ningbo city","volume":"41","author":"Chen","year":"2020","journal-title":"Chin. J. Epidemiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.devcel.2020.05.012","article-title":"Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract","volume":"53","author":"Smith","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_55","unstructured":"de Celles, M.D., Casalegno, J.-S., Lina, B., and Opatowski, L. (2020). Influenza may facilitate the spread of SARS-CoV-2. medRxiv."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Linton, N.M., Kobayashi, T., Yang, Y., Hayashi, K., Akhmetzhanov, A.R., Jung, S., Yuan, B., Kinoshita, R., and Nishiura, H. (2020). Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: A statistical analysis of publicly available case data. J. Clin. Med., 9.","DOI":"10.1101\/2020.01.26.20018754"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/s41594-020-0511-8","article-title":"SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation","volume":"27","author":"Schubert","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1089\/dna.2020.5703","article-title":"The Novel Insight of SARS-CoV-2 Molecular Biology and Pathogenesis and Therapeutic Options","volume":"39","author":"Asghari","year":"2020","journal-title":"DNA Cell Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e00003-17","DOI":"10.1128\/JVI.00003-17","article-title":"Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving STAT2","volume":"91","author":"Zhu","year":"2017","journal-title":"J. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhou, L., Zhang, J., Ge, X., Zhou, R., Zheng, H., Geng, G., Guo, X., and Yang, H. (2014). Nsp9 and Nsp10 contribute to the fatal virulence of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004216"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1038\/s41467-019-10280-3","article-title":"Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors","volume":"10","author":"Kirchdoerfer","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12250-020-00242-1","article-title":"SARS-Coronavirus-2 Nsp13 possesses NTPase and RNA helicase activities that can be inhibited by bismuth salts","volume":"35","author":"Shu","year":"2020","journal-title":"Virol. Sin."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1080\/22221751.2020.1780953","article-title":"SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists","volume":"9","author":"Yuen","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1126\/science.abd3629","article-title":"A molecular pore spans the double membrane of the coronavirus replication organelle","volume":"369","author":"Wolff","year":"2020","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.molcel.2020.07.027","article-title":"Coronavirus RNA proofreading: Molecular basis and therapeutic targeting","volume":"79","author":"Robson","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1038\/s41467-020-17888-w","article-title":"Influenza A virus is transmissible via aerosolized fomites","volume":"11","author":"Asadi","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e2171","DOI":"10.1002\/rmv.2171","article-title":"The unique features of SARS-CoV-2 transmission: Comparison with SARS-CoV, MERS-CoV and 2009 H1N1 pandemic influenza virus","volume":"31","author":"Wu","year":"2021","journal-title":"Rev. Med. Virol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"taaa021","DOI":"10.1093\/jtm\/taaa021","article-title":"The reproductive number of COVID-19 is higher compared to SARS coronavirus","volume":"27","author":"Liu","year":"2020","journal-title":"J. Travel Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1128\/JVI.03176-12","article-title":"Influenza A virus NS1 induces G0\/G1 cell cycle arrest by inhibiting the expression and activity of RhoA protein","volume":"87","author":"Jiang","year":"2013","journal-title":"J. Virol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.3389\/fimmu.2018.01581","article-title":"Influenza A virus cell entry, replication, virion assembly and movement","volume":"9","author":"Dou","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_71","first-page":"350","article-title":"hisT1h1c regulates interferon-$\u03b2$ and inhibits influenza Virus replication by interacting with irF3","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1111\/febs.14867","article-title":"Evidence for a novel mechanism of influenza A virus host adaptation modulated by PB 2-627","volume":"286","author":"Liu","year":"2019","journal-title":"FEBS J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"8849","DOI":"10.1128\/JVI.00456-10","article-title":"Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells","volume":"84","author":"Song","year":"2010","journal-title":"J. Virol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41569-020-0360-5","article-title":"COVID-19 and the cardiovascular system","volume":"17","author":"Zheng","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"216","DOI":"10.14336\/AD.2020.0228","article-title":"Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia","volume":"11","author":"Leng","year":"2020","journal-title":"Aging Dis."},{"key":"ref_77","first-page":"908","article-title":"A novel influenza A H1N1 clinical manifestations in patients at Chiang Mai University Hospital","volume":"94","author":"Chaiwarith","year":"2011","journal-title":"J. Med. Assoc. Thail."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1136\/gut.2009.194746","article-title":"Gastrointestinal manifestations among Chilean patients infected with novel influenza A (H1N1) 2009 virus","volume":"58","author":"Riquelme","year":"2009","journal-title":"Gut"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1467-789X.2011.00864.x","article-title":"Obesity is associated with higher risk of intensive care unit admission and death in influenza A (H1N1) patients: A systematic review and meta-analysis","volume":"12","author":"Fezeu","year":"2011","journal-title":"Obes. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e13034","DOI":"10.1111\/obr.13034","article-title":"Risk of COVID-19 for patients with obesity","volume":"21","author":"Kassir","year":"2020","journal-title":"Obes. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"108961","DOI":"10.1016\/j.ejrad.2020.108961","article-title":"Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?","volume":"126","author":"Long","year":"2020","journal-title":"Eur. J. Radiol."},{"key":"ref_82","first-page":"201","article-title":"CRISPR\/Cas as a potential diagnosis technique for COVID-19","volume":"12","author":"Dara","year":"2020","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"19329","DOI":"10.2807\/ese.14.36.19329-en","article-title":"Detection of influenza A (H1N1) v virus by real-time RT-PCR","volume":"14","author":"Panning","year":"2009","journal-title":"Eurosurveillance"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40560-020-00453-4","article-title":"Lymphopenia in severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis","volume":"8","author":"Huang","year":"2020","journal-title":"J. Intensive Care"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jiph.2019.05.017","article-title":"Dynamic changes of lymphocyte counts in adult patients with severe pandemic H1N1 influenza A","volume":"12","author":"Cheng","year":"2019","journal-title":"J. Infect. Public Health"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1093\/cid\/ciaa709","article-title":"Alterations of the gut microbiota in patients with coronavirus disease 2019 or H1N1 influenza","volume":"71","author":"Gu","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Deriu, E., Boxx, G.M., He, X., Pan, C., Benavidez, S.D., Cen, L., Rozengurt, N., Shi, W., and Cheng, G. (2016). Influenza virus affects intestinal microbiota and secondary salmonella infection in the gut through type I interferons. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005572"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s10787-020-00745-z","article-title":"A narrative review of the potential pharmacological influence and safety of ibuprofen on coronavirus disease 19 (COVID-19), ACE2, and the immune system: A dichotomy of expectation and reality","volume":"28","author":"Smart","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijcard.2020.03.087","article-title":"Suspected myocardial injury in patients with COVID-19: Evidence from front-line clinical observation in Wuhan, China","volume":"311","author":"Deng","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41392-020-00373-7","article-title":"COVID-19-associated gastrointestinal and liver injury: Clinical features and potential mechanisms","volume":"5","author":"Zhong","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_91","first-page":"615","article-title":"Gastrointestinal predictors of severe COVID-19: Systematic review and meta-analysis","volume":"33","author":"Aziz","year":"2020","journal-title":"Ann. Gastroenterol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41392-020-00355-9","article-title":"Pathological features of COVID-19-associated lung injury: A preliminary proteomics report based on clinical samples","volume":"5","author":"Leng","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1128\/JCM.00418-10","article-title":"Cardiac tamponade and heart failure due to myopericarditis as a presentation of infection with the pandemic H1N1 2009 influenza A virus","volume":"48","author":"Puzelli","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.1177238","article-title":"Transmission and pathogenesis of swine-origin 2009 A (H1N1) influenza viruses in ferrets and mice","volume":"325","author":"Maines","year":"2009","journal-title":"Science"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"17916","DOI":"10.1038\/srep17916","article-title":"Transcription factor Runx3 is induced by influenza A virus and double-strand RNA and mediates airway epithelial cell apoptosis","volume":"5","author":"Gan","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.orcp.2020.07.005","article-title":"Impact of obesity on hospitalizations and mortality, due to COVID-19: A systematic review","volume":"14","author":"Almeida","year":"2020","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref_97","first-page":"339","article-title":"Coronavirus COV-19\/SARS-CoV-2 affects women less than men: Clinical response to viral infection","volume":"34","author":"Conti","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1093\/eurheartj\/ehaa373","article-title":"Circulating plasma concentrations of ACE2 in men and women with heart failure and effects of renin-angiotensin-aldosterone-inhibitors","volume":"41","author":"Sama","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/14737159.2020.1757437","article-title":"Real-time RT-PCR in COVID-19 detection: Issues affecting the results","volume":"20","author":"Tahamtan","year":"2020","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_100","first-page":"201","article-title":"Who or what is SHERLOCK?","volume":"29","author":"Gronowski","year":"2018","journal-title":"Ejifcc"},{"key":"ref_101","first-page":"1023506","article-title":"Computed tomography (CT) imaging features of patients with COVID-19: Systematic review and meta-analysis","volume":"2020","author":"Awulachew","year":"2020","journal-title":"Radiol. Res. Pract."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6928368","DOI":"10.1155\/2020\/6928368","article-title":"Chest computed tomography findings in COVID-19 and influenza: A narrative review","volume":"2020","author":"Onigbinde","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.cll.2014.02.009","article-title":"Rapid diagnosis of influenza: State of the art","volume":"34","author":"Peaper","year":"2014","journal-title":"Clin. Lab. Med."},{"key":"ref_104","first-page":"1","article-title":"Comparative analysis of molecular methods for detection of influenza viruses","volume":"17","author":"Sharma","year":"2016","journal-title":"Microbiol. Res. J. Int."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.diagmicrobio.2010.11.007","article-title":"Comparison of real-time RT-PCR, shell vial culture, and conventional cell culture for the detection of the pandemic influenza A (H1N1) in hospitalized patients","volume":"69","author":"Roa","year":"2011","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/atm.ATM_147_20","article-title":"Amphotericin B as antiviral drug: Possible efficacy against COVID-19","volume":"15","year":"2020","journal-title":"Ann. Thorac. Med."},{"key":"ref_107","unstructured":"Wang, K.Y., Liu, F., Jiang, R., Yang, X., You, T., Liu, X., Xiao, C.Q., Shi, Z., Jiang, H., and Rao, Z. (2020). Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","article-title":"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Pizzini, A., Aichner, M., Sahanic, S., B\u00f6hm, A., Egger, A., Hoermann, G., Kurz, K., Widmann, G., Bellmann-Weiler, R., and Weiss, G. (2020). Impact of vitamin d deficiency on COVID-19\u2014A prospective analysis from the CovILD registry. Nutrients, 12.","DOI":"10.3390\/nu12092775"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"102554","DOI":"10.1016\/j.autrev.2020.102554","article-title":"Convalescent plasma in Covid-19: Possible mechanisms of action","volume":"19","author":"Rojas","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"9490","DOI":"10.1073\/pnas.2004168117","article-title":"Effectiveness of convalescent plasma therapy in severe COVID-19 patients","volume":"117","author":"Duan","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jinf.2020.03.037","article-title":"The pathogenesis and treatment of theCytokine Storm\u2019in COVID-19","volume":"80","author":"Ye","year":"2020","journal-title":"J. Infect."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41536-020-00105-z","article-title":"Insights into the use of mesenchymal stem cells in COVID-19 mediated acute respiratory failure","volume":"5","author":"Durand","year":"2020","journal-title":"NPJ Regen. Med."},{"key":"ref_114","unstructured":"Raza, S.S., and Khan, M.A. (2020). Mesenchymal Stem Cells: A new front emerge in COVID19 treatment: Mesenchymal Stem Cells therapy for SARS-CoV2 viral infection. Cytotherapy, in press."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Barik, S. (2012). New treatments for influenza. BMC Med., 10.","DOI":"10.1186\/1741-7015-10-104"},{"key":"ref_116","first-page":"1","article-title":"Influenza viruses\u2013antiviral therapy and resistance","volume":"5","author":"Duwe","year":"2017","journal-title":"GMS Infect. Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"17261","DOI":"10.1074\/jbc.M112.438515","article-title":"Interferon-inducible transmembrane protein 3 (IFITM3) restricts reovirus cell entry","volume":"288","author":"Anafu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_118","first-page":"19","article-title":"Serum vitamin D concentration in pandemic 2009 H1N1 influenza infected patients","volume":"9","author":"Khalili","year":"2010","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/cid\/ciq106","article-title":"Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection","volume":"52","author":"Hung","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Di Gennaro, F., Pizzol, D., Marotta, C., Antunes, M., Racalbuto, V., Veronese, N., and Smith, L. (2020). Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17082690"},{"key":"ref_121","first-page":"116","article-title":"A review of COVID-19 (Coronavirus Disease-2019) diagnosis, treatments and prevention","volume":"4","author":"Hafeez","year":"2020","journal-title":"EJMO"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40123-020-00255-9","article-title":"Ophthalmology practice during the coronavirus disease 2019 pandemic: The University of Pittsburgh experience in promoting clinic safety and embracing video visits","volume":"9","author":"Williams","year":"2020","journal-title":"Ophthalmol. Ther."},{"key":"ref_123","first-page":"2019","article-title":"Coronavirus disease 2019 (COVID-19): Epidemiology, virology, and prevention","volume":"1","author":"McIntosh","year":"2020","journal-title":"Lancet. Infect. Dis"},{"key":"ref_124","first-page":"e7","article-title":"Assessing fever frequency after pediatric live attenuated versus inactivated influenza vaccination","volume":"6","author":"Stockwell","year":"2017","journal-title":"J. Pediat. Infect. Dis. Soc."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41591-018-0340-z","article-title":"Current and future influenza vaccines","volume":"25","author":"Yamayoshi","year":"2019","journal-title":"Nat. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"9823","DOI":"10.1128\/JVI.77.18.9823-9830.2003","article-title":"Mucosal immunization with virus-like particles of simian immunodeficiency virus conjugated with cholera toxin subunit B","volume":"77","author":"Kang","year":"2003","journal-title":"J. Virol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-065X.2010.00974.x","article-title":"Influenza vaccine immunology","volume":"239","author":"Dormitzer","year":"2011","journal-title":"Immunol. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJMoa065368","article-title":"Live attenuated versus inactivated influenza vaccine in infants and young children","volume":"356","author":"Belshe","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1080\/21645515.2017.1415684","article-title":"Adjuvanted influenza vaccines","volume":"14","author":"Tregoning","year":"2018","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., Zhu, H., Zhao, W., Han, Y., and Qin, C. (2019). From SARS to MERS, thrusting coronaviruses into the spotlight. Viruses, 11.","DOI":"10.3390\/v11010059"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/bs.aivir.2016.08.003","article-title":"Molecular basis of coronavirus virulence and vaccine development","volume":"96","author":"Enjuanes","year":"2016","journal-title":"Adv. Virus Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41565-020-0737-y","article-title":"COVID-19 vaccine development and a potential nanomaterial path forward","volume":"15","author":"Shin","year":"2020","journal-title":"Nat. Nanotechnol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.cell.2020.03.045","article-title":"Structural and functional basis of SARS-CoV-2 entry by using human ACE2","volume":"181","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"vev005","DOI":"10.1093\/ve\/vev005","article-title":"Evolutionary reversion of live viral vaccines: Can genetic engineering subdue it?","volume":"1","author":"Bull","year":"2015","journal-title":"Virus Evol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1126\/science.aah5869","article-title":"Generation of influenza A viruses as live but replication-incompetent virus vaccines","volume":"354","author":"Si","year":"2016","journal-title":"Science"},{"key":"ref_136","unstructured":"Cheung, E. (2021, June 07). China Coronavirus: Hong Kong Researchers have Already Developed Vaccine but Need Time to Test it, Expert Reveals: South China Morning Post. Available online: https:\/\/www.scmp.com\/news\/hong-kong\/health-environment\/article\/3047956\/china-coronavirus-hong-kong-researchers-have."},{"key":"ref_137","unstructured":"Shieber, J. (2021, June 07). Codagenix Raises $20 Million for a New Flu Vaccine and Other Therapies; Tech Crunch. Available online: https:\/\/techcrunch.com\/2020\/01\/13\/codagenix-raises-20-million-for-a-new-flu-vaccine-and-other-therapies\/."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.smim.2018.10.010","article-title":"Vaccination in the elderly: The challenge of immune changes with aging","volume":"40","author":"Ciabattini","year":"2018","journal-title":"Proc. Semin. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0140-6736(17)31665-3","article-title":"Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: An open-label, non-randomised, prospective, first-in-human phase 1 clinical trial","volume":"390","author":"Alberer","year":"2017","journal-title":"Lancet"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd.2017.243","article-title":"mRNA vaccines\u2014A new era in vaccinology","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nri3488","article-title":"Applications of nanotechnology for immunology","volume":"13","author":"Smith","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1056\/NEJMoa2024671","article-title":"Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates","volume":"383","author":"Corbett","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"m4826","DOI":"10.1136\/bmj.m4826","article-title":"Covid-19: Pfizer vaccine efficacy was 52% after first dose and 95% after second dose, paper shows","volume":"371","author":"Mahase","year":"2020","journal-title":"BMJ"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Mahase, E. (2020). Covid-19: Moderna applies for US and EU approval as vaccine trial reports 94.1% efficacy. BMJ Br. Med. J., 371.","DOI":"10.1136\/bmj.m4709"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Dicks, M.D.J., Spencer, A.J., Edwards, N.J., Wadell, G., Bojang, K., Gilbert, S.C., Hill, A.V.S., and Cottingham, M.G. (2012). A novel chimpanzee adenovirus vector with low human seroprevalence: Improved systems for vector derivation and comparative immunogenicity. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040385"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.4161\/hv.29594","article-title":"Pre-existing immunity against Ad vectors: Humoral, cellular, and innate response, what\u2019s important?","volume":"10","author":"Kobinger","year":"2014","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0140-6736(20)32623-4","article-title":"Oxford\u2013AstraZeneca COVID-19 vaccine efficacy","volume":"397","author":"Knoll","year":"2021","journal-title":"Lancet"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s40475-020-00201-6","article-title":"The SARS-CoV-2 vaccine pipeline: An overview","volume":"7","author":"Chen","year":"2020","journal-title":"Curr. Trop. Med. Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.xphs.2017.04.037","article-title":"Optimization of the production process and characterization of the yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1), a SARS vaccine candidate","volume":"106","author":"Chen","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jaci.2017.12.971","article-title":"Vaccine-associated hypersensitivity","volume":"141","author":"McNeil","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr6803a1","article-title":"Prevention and control of seasonal influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices\u2014United States, 2019\u20132020 influenza season","volume":"68","author":"Grohskopf","year":"2019","journal-title":"MMWR Recomm. Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1056\/NEJMoa0908535","article-title":"A novel influenza A (H1N1) vaccine in various age groups","volume":"361","author":"Zhu","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_153","first-page":"751","article-title":"Influenza: Diagnosis and treatment","volume":"100","author":"Gaitonde","year":"2019","journal-title":"Am. Fam. Physician"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/6\/1145\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:13:03Z","timestamp":1774944783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/6\/1145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":153,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["v13061145"],"URL":"https:\/\/doi.org\/10.3390\/v13061145","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]}}}