{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:12:38Z","timestamp":1792588358618,"version":"4.5.0"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19jm0210047h0004, JP20wm0125006, 19fk0108109h0001, 20fk0108109h0001, 20fk0108123h1101"],"award-info":[{"award-number":["19jm0210047h0004, JP20wm0125006, 19fk0108109h0001, 20fk0108109h0001, 20fk0108123h1101"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Dengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease severity is understood. In this study, we analyzed DENV-1, DENV-2, DENV-3, and DENV-4 serotypes in 1235 serum samples collected in Myanmar between 2017 and 2019. Whole-genome sequencing of DENV-1\u20134 demonstrated that most DENV-1\u20134 strains had been circulating in Myanmar for several years. We also identified the emergence of DENV-3 genotype-I in 2017 samples, which persisted through 2018 and 2019. The emergence of the strain coincided with a period of increased DENV-3 cases and marked changes in the serotype dynamics. Nevertheless, we detected no significant differences between serum viral loads, disease severity, and infection status of individuals infected with different DENV serotypes during the 3-year study. Our results not only identify the spread of a new DENV-3 genotype into Yangon, Myanmar, but also support the importance of DENV evolution in changing the epidemic dynamics in endemic regions.<\/jats:p>","DOI":"10.3390\/v13061152","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T21:58:32Z","timestamp":1623880712000},"page":"1152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-8420","authenticated-orcid":false,"given":"Aung Min","family":"Soe","sequence":"first","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"},{"name":"Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan"},{"name":"Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Nagasaki University, Nagasaki 852-8501, Japan"},{"name":"Department of Medical Research, Yangon 11191, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mya Myat","family":"Ngwe Tun","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nabeshima","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theingi Win","family":"Myat","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Yangon 11191, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moh Moh","family":"Htun","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Yangon 11191, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Htin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Yangon 11191, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nang Sarm","family":"Hom","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Yangon 11191, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"},{"name":"Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khine Mya","family":"Nwe","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"},{"name":"Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn Pa Pa","family":"Aye","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Yangon 11191, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Fukuta","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"},{"name":"Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyaw Zin","family":"Thant","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Yangon 11191, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futoshi","family":"Hasebe","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan"},{"name":"Research Center for Infectious Disease Research in Asia and Africa, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"},{"name":"Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-8474","authenticated-orcid":false,"given":"Sujan","family":"Shresta","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Immunology, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hlaing Myat","family":"Thu","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Yangon 11191, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-6659","authenticated-orcid":false,"given":"Meng Ling","family":"Moi","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"},{"name":"Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"ref_1","unstructured":"(2021, March 14). 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