{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:06:15Z","timestamp":1765713975972,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>There are some reports and case series addressing Coronavirus Disease 2019 (COVID-19) infections during pregnancy in upper income countries, but there are few data on pregnant women with comorbid conditions in low and middle income Countries. This study evaluated the proportion and the maternal and neonatal outcomes associated with SARS-CoV-2 infection among pregnant women with comorbidities. Participants were recruited consecutively in order of admission to a maternity for pregnant women with comorbidities. Sociodemographic, clinical, and laboratory data were prospectively collected during hospitalization. Pregnant women were screened at entry: nasopharyngeal swabs were tested by RT-PCR; serum samples were tested for IgG antibodies against spike protein by ELISA. From April to June 2020, 115 eligible women were included in the study. The proportion of SARS-CoV-2 infection was 28.7%. The rate of obesity was 60.9%, vascular hypertension 40.0%, and HIV 21.7%. The most common clinical presentations were ageusia (21.2%), anosmia (18.2%), and fever (18.2%). Prematurity was higher among mothers who had a SARS-CoV-2 infection based on RT-PCR. There were two cases of fetal demise. We found a high proportion of COVID-19 among pregnant women with comorbidities. This underscores the importance of antenatal care during the pandemic to implement universal SARS-CoV-2 screening, precautionary measures, and the rollout of vaccination programs for pregnant women.<\/jats:p>","DOI":"10.3390\/v13071277","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T02:44:39Z","timestamp":1625107479000},"page":"1277","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Maternal and Neonatal Outcomes of SARS-CoV-2 Infection in a Cohort of Pregnant Women with Comorbid Disorders"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6896-0089","authenticated-orcid":false,"given":"Maria de Lourdes Benamor","family":"Teixeira","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Anexo IV 4\u00b0 Andar, Rio de Janeiro 20221-161, RJ, Brazil"},{"name":"Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz, Av. Brasil, 4365\u2014Manguinhos, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando da","family":"Costa Ferreira J\u00fanior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Departamento de Gen\u00e9tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373\u2014Sala A1-050\u2014Cidade Universit\u00e1ria da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0627","authenticated-orcid":false,"given":"Esa\u00fa","family":"Jo\u00e3o","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Anexo IV 4\u00b0 Andar, Rio de Janeiro 20221-161, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevon","family":"Fuller","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Anexo IV 4\u00b0 Andar, Rio de Janeiro 20221-161, RJ, Brazil"},{"name":"Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz, Av. Brasil, 4365\u2014Manguinhos, Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Silva Esteves","sequence":"additional","affiliation":[{"name":"Maternal Fetal Department and Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Rio de Janeiro 20221-161, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wallace","family":"Mendes-Silva","sequence":"additional","affiliation":[{"name":"Maternal Fetal Department and Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Rio de Janeiro 20221-161, RJ, Brazil"},{"name":"Perinatal Health Program, Maternidade Escola, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373\u2014Sala A1-050\u2014Cidade Universit\u00e1ria da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Carvalho Mocarzel","sequence":"additional","affiliation":[{"name":"Maternal Fetal Department and Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Rio de Janeiro 20221-161, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Ara\u00fajo Maia","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Departamento de Gen\u00e9tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373\u2014Sala A1-050\u2014Cidade Universit\u00e1ria da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00eddia","family":"Theodoro Boullosa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Departamento de Gen\u00e9tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373\u2014Sala A1-050\u2014Cidade Universit\u00e1ria da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1ssia Cristina Alves","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Departamento de Gen\u00e9tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373\u2014Sala A1-050\u2014Cidade Universit\u00e1ria da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Pontes","family":"Frankel","sequence":"additional","affiliation":[{"name":"Maternal Fetal Department and Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Rio de Janeiro 20221-161, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Fragoso da Silveira Gouv\u00eaa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Anexo IV 4\u00b0 Andar, Rio de Janeiro 20221-161, RJ, Brazil"},{"name":"Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz, Av. 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