{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:21:23Z","timestamp":1774362083966,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PROMIS ID P00144_20_N6_02, 2019-2020"],"award-info":[{"award-number":["PROMIS ID P00144_20_N6_02, 2019-2020"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>As demonstrated with the novel coronavirus pandemic, rapid and accurate diagnosis is key to determine the clinical characteristic of a disease and to improve vaccine development. Once the infected person is identified, hematological findings may be used to predict disease outcome and offer the correct treatment. Rapid and accurate diagnosis and clinical parameters are pivotal to track infections during clinical trials and set protection status. This is also applicable for re-emerging diseases like dengue fever, which causes outbreaks in Asia and Latin America every 4 to 5 years. Some areas in the US are also endemic for the transmission of dengue virus (DENV), the causal agent of dengue fever. However, significant number of DENV infections in rural areas are diagnosed solely by clinical and hematological findings because of the lack of availability of ELISA or PCR-based tests or the infrastructure to implement them in the near future. Rapid diagnostic tests (RDT) are a less sensitive, yet they represent a timely way of detecting DENV infections. The purpose of this study was to determine whether there is an association between hematological findings and the probability for an NS1-based DENV RDT to detect the DENV NS1 antigen. We also aimed to describe the hematological parameters that are associated with the diagnosis through each test.<\/jats:p>","DOI":"10.3390\/v13071401","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T10:07:37Z","timestamp":1626689257000},"page":"1401","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018"],"prefix":"10.3390","volume":"13","author":[{"given":"Jenny","family":"Cardenas","sequence":"first","affiliation":[{"name":"Vector Biology Laboratory, Department of Entomology, Kansas State University, Manhattan, KS 66505, USA"},{"name":"Clinical Laboratory, Los Patios Local Hospital, Los Patios, Norte de Santander 547079, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Giraldo-Parra","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Los Patios Local Hospital, Los Patios, Norte de Santander 547079, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Vector Biology Laboratory, Department of Entomology, Kansas State University, Manhattan, KS 66505, USA"},{"name":"Clinical Laboratory, Hospital Universitario Erasmo Meoz, Cucuta, Norte de Santander 547079, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lady","family":"Gutierrez-Silva","sequence":"additional","affiliation":[{"name":"Vector Biology Laboratory, Department of Entomology, Kansas State University, Manhattan, KS 66505, USA"},{"name":"Clinical Laboratory, Hospital Emiro Quintero Ca\u00f1izares, Ocana, Norte de Santander 547079, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Jaimes-Villamizar","sequence":"additional","affiliation":[{"name":"Vector Biology Laboratory, Department of Entomology, Kansas State University, Manhattan, KS 66505, USA"},{"name":"Clinical Laboratory, Hospital Jorge Cristo Sahium, Villa del Rosario, Norte de Santander 547079, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Roa-Parra","sequence":"additional","affiliation":[{"name":"Vector Biology Laboratory, Department of Entomology, Kansas State University, Manhattan, KS 66505, USA"},{"name":"Department of Microbiology, Universidad de Pamplona, Pamplona, Norte de Santander 547079, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Vector Biology Laboratory, Department of Entomology, Kansas State University, Manhattan, KS 66505, USA"},{"name":"Department of Microbiology, Universidad de Pamplona, Pamplona, Norte de Santander 547079, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Valdivia","sequence":"additional","affiliation":[{"name":"Department of Parasitology, U.S. Naval Medical Research Unit No. 6 (NAMRU-6), Callao 07001, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Parasitology, U.S. Naval Medical Research Unit No. 6 (NAMRU-6), Callao 07001, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonya","family":"Colpitts","sequence":"additional","affiliation":[{"name":"National Emerging Infectious Diseases Laboratories, Department of Microbiology, Boston University School of Medicine, Boston, MA 02128, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-5274","authenticated-orcid":false,"given":"Berlin","family":"Londono-Renteria","sequence":"additional","affiliation":[{"name":"Vector Biology Laboratory, Department of Entomology, Kansas State University, Manhattan, KS 66505, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref_1","unstructured":"WHO (2020). 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