{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:10:55Z","timestamp":1790507455870,"version":"4.1.0"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U01AI151801-01"],"award-info":[{"award-number":["1U01AI151801-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001125","name":"GAVI Alliance","doi-asserted-by":"publisher","award":["CP 9035 08 20"],"award-info":[{"award-number":["CP 9035 08 20"]}],"id":[{"id":"10.13039\/100001125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Yellow fever virus remains a major threat in low resource countries in South America and Africa despite the existence of an effective vaccine. In Senegal and particularly in the eastern part of the country, periodic sylvatic circulation has been demonstrated with varying degrees of impact on populations in perpetual renewal. We report an outbreak that occurred from October 2020 to February 2021 in eastern Senegal, notified and managed through the synergistic effort yellow fever national surveillance implemented by the Senegalese Ministry of Health in collaboration with the World Health Organization, the countrywide 4S network set up by the Ministry of Health, the Institut Pasteur de Dakar, and the surveillance of arboviruses and hemorrhagic fever viruses in human and vector populations implemented since mid 2020 in eastern Senegal. Virological analyses highlighted the implication of sylvatic mosquito species in virus transmission. Genomic analysis showed a close relationship between the circulating strain in eastern Senegal, 2020, and another one from the West African lineage previously detected and sequenced two years ago from an unvaccinated Dutch traveler who visited the Gambia and Senegal before developing signs after returning to Europe. Moreover, genome analysis identified a 6-nucleotide deletion in the variable domain of the 3\u2032UTR with potential impact on the biology of the viral strain that merits further investigations. Integrated surveillance of yellow fever virus but also of other arboviruses of public health interest is crucial in an ecosystem such as eastern Senegal.<\/jats:p>","DOI":"10.3390\/v13081475","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T21:21:04Z","timestamp":1627507264000},"page":"1475","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Yellow Fever Outbreak in Eastern Senegal, 2020\u20132021"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5461-5623","authenticated-orcid":false,"given":"Moussa Mo\u00efse","family":"Diagne","sequence":"first","affiliation":[{"name":"Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Henriette Dior","family":"Ndione","sequence":"additional","affiliation":[{"name":"Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alioune","family":"Gaye","sequence":"additional","affiliation":[{"name":"Zoology Medical Department, Institut Pasteur de Dakar, Dakar 220, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou Aliou","family":"Barry","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-5248","authenticated-orcid":false,"given":"Diawo","family":"Diallo","sequence":"additional","affiliation":[{"name":"Zoology Medical Department, Institut Pasteur de Dakar, Dakar 220, 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Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9582-4197","authenticated-orcid":false,"given":"Cheikh","family":"Loucoubar","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-1325","authenticated-orcid":false,"given":"Gamou","family":"Fall","sequence":"additional","affiliation":[{"name":"Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina M.","family":"Tato","sequence":"additional","affiliation":[{"name":"Chan Zuckerberg Biohub, San Francisco, CA 94158, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou Alpha","family":"Sall","sequence":"additional","affiliation":[{"name":"Virology Department, Institut Pasteur de 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