{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:49:34Z","timestamp":1776793774861,"version":"3.51.2"},"reference-count":86,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FOCEM-Fondo para la Convergencia Estructural del Mercosur","award":["COF03\/11"],"award-info":[{"award-number":["COF03\/11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November 2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic wave in Uruguay (December 2020\u2013February 2021) was a B.1.1.28 sublineage carrying Spike mutations Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around November 2020, in Montevideo, Uruguay\u2019s capital department, and rapidly spread to other departments, with evidence of further local transmission clusters; it also spread sporadically to the USA and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1\/S2 boundary suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of worldwide interest.<\/jats:p>","DOI":"10.3390\/v13091801","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T21:48:01Z","timestamp":1631483281000},"page":"1801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6944-2825","authenticated-orcid":false,"given":"Natalia","family":"Rego","sequence":"first","affiliation":[{"name":"Bioinformatics Unit, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Salazar","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica Microbiana, Institut Pasteur Montevideo, Montevideo 11400, Uruguay"},{"name":"Centro de Innovaci\u00f3n en Vigilancia Epidemiol\u00f3gica, Institut Pasteur Montevideo, Montevideo 11400, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Paz","sequence":"additional","affiliation":[{"name":"Centro de Innovaci\u00f3n en Vigilancia Epidemiol\u00f3gica, Institut Pasteur Montevideo, Montevideo 11400, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Cost\u00e1bile","sequence":"additional","affiliation":[{"name":"Centro de Innovaci\u00f3n en Vigilancia Epidemiol\u00f3gica, Institut Pasteur Montevideo, Montevideo 11400, Uruguay"},{"name":"Laboratorio de Virolog\u00eda Molecular, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"},{"name":"Laboratorio de Evoluci\u00f3n Experimental de Virus, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay"},{"name":"Secci\u00f3n Bioqu\u00edmica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Fajardo","sequence":"additional","affiliation":[{"name":"Laboratorio de Virolog\u00eda Molecular, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo 11400, Uruguay"},{"name":"Laboratorio de Evoluci\u00f3n Experimental de Virus, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-6568","authenticated-orcid":false,"given":"Ignacio","family":"Ferr\u00e9s","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica Microbiana, Institut Pasteur Montevideo, Montevideo 11400, Uruguay"},{"name":"Centro de 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