{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:00:33Z","timestamp":1790841633815,"version":"4.1.0"},"reference-count":183,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Southwest Minzu University Research Startup Fund","award":["125900\/16011211013"],"award-info":[{"award-number":["125900\/16011211013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia would provide valuable information into the pathogenesis of viral infections and potential therapeutic targeting. In this review, the current progress of viruses-induced lymphopenia is summarized and the potential mechanisms and factors involved are discussed.<\/jats:p>","DOI":"10.3390\/v13091876","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T22:35:20Z","timestamp":1632263720000},"page":"1876","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Lymphopenia Caused by Virus Infections and the Mechanisms Beyond"],"prefix":"10.3390","volume":"13","author":[{"given":"Zijing","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory on Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730030, China"},{"name":"College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-9172","authenticated-orcid":false,"given":"Meera","family":"Prajapati","sequence":"additional","affiliation":[{"name":"College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China"},{"name":"National Animal Health Research Centre, Nepal Agricultural Research Council, Lalitpur 44700, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.5114\/ceji.2018.77390","article-title":"Immunological memory cells","volume":"43","author":"Ratajczak","year":"2018","journal-title":"Cent. 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