{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:10:29Z","timestamp":1792131029587,"version":"4.4.0"},"reference-count":48,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/H009175\/1, BB\/N012682\/1, BB\/F009186\/1; BBS\/E\/I\/00007030, BBS\/E\/I\/00007031, BBS\/E\/I\/00007036 and BBS\/E\/I\/00007037"],"award-info":[{"award-number":["BB\/H009175\/1, BB\/N012682\/1, BB\/F009186\/1; BBS\/E\/I\/00007030, BBS\/E\/I\/00007031, BBS\/E\/I\/00007036 and BBS\/E\/I\/00007037"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals with serious economic consequences. FMD is endemic in Southeast Asia (SEA) and East Asia (EA) with the circulation of multiple serotypes, posing a threat to Australia and other FMD-free countries. Although vaccination is one of the most important control measures to prevent FMD outbreaks, the available vaccines may not be able to provide enough cross-protection against the FMD viruses (FMDVs) circulating in these countries due to the incursion of new lineages and sub-lineages as experienced in South Korea during 2010, a FMD-free country, when a new lineage of serotype O FMDV (Mya-98) spread to the country, resulting in devastating economic consequences. In this study, a total of 62 serotype O (2013\u20132018) viruses selected from SEA and EA countries were antigenically characterized by virus neutralization tests using three existing (O\/HKN\/6\/83, O\/IND\/R2\/75 and O\/PanAsia-2) and one putative (O\/MYA\/2009) vaccine strains and full capsid sequencing. The Capsid sequence analysis revealed three topotypes, Cathay, SEA and Middle East-South Asia (ME-SA) of FMDVs circulating in the region. The vaccines used in this study showed a good match with the SEA and ME-SA viruses. However, none of the recently circulating Cathay topotype viruses were protected by any of the vaccine strains, including the existing Cathay topotype vaccine (O\/HKN\/6\/83), indicating an antigenic drift and, also the urgency to monitor this topotype in the region and develop a new vaccine strain if necessary, although currently the presence of this topotype is mainly restricted to China, Hong Kong, Taiwan and Vietnam. Further, the capsid sequences of these viruses were analyzed that identified several capsid amino acid substitutions involving neutralizing antigenic sites 1, 2 and 5, which either individually or together could underpin the observed antigenic drift.<\/jats:p>","DOI":"10.3390\/v13091886","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T22:35:20Z","timestamp":1632263720000},"page":"1886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Molecular Basis of Antigenic Drift in Serotype O Foot-and-Mouth Disease Viruses (2013\u20132018) from Southeast Asia"],"prefix":"10.3390","volume":"13","author":[{"given":"Sasmita","family":"Upadhyaya","sequence":"first","affiliation":[{"name":"The Pirbright Institute, Ash Road, Pirbright GU24 ONF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3977-1465","authenticated-orcid":false,"given":"Mana","family":"Mahapatra","sequence":"additional","affiliation":[{"name":"The Pirbright Institute, Ash Road, Pirbright GU24 ONF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Mioulet","sequence":"additional","affiliation":[{"name":"The Pirbright Institute, Ash Road, Pirbright GU24 ONF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-9461","authenticated-orcid":false,"given":"Satya","family":"Parida","sequence":"additional","affiliation":[{"name":"The Pirbright Institute, Ash Road, Pirbright GU24 ONF, UK"},{"name":"Food and Agriculture Organization of the United Nations (FAO), 00153 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1865-1682.2007.01013.x","article-title":"Epidemiological Patterns of Foot-and-Mouth Disease Worldwide","volume":"55","author":"Rweyemamu","year":"2008","journal-title":"Transbound. 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