{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T15:43:53Z","timestamp":1767109433729,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Health Industry Development Institute (KHIDI)","award":["HI18C1836"],"award-info":[{"award-number":["HI18C1836"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Equine parvovirus-hepatitis (EqPV-H) is a newly identified etiologic agent of Theiler\u2019s disease (TD). We present a case of EqPV-H-related fulminant hepatitis in a 14-year-old thoroughbred mare in Korea. The mare had acute hepatopathy and gastrointestinal symptoms, with abnormal liver-related blood parameters. The horse was born in the USA and imported to Korea in 2017, with no history of administration of equine biological products after entry into Korea. The horse was diagnosed with EqPV-H-associated hepatitis after abdominal ultrasonography, laparotomy, and nested polymerase chain reaction (PCR) and in situ hybridization (ISH) assays. The serum, nasal swab, oral swab, and liver biopsy were positive for EqPV-H according to the PCR assay. Genetic analysis of the partial NS1 gene of EqPV-H showed a unique nucleotide substitution, distinct from that in previously deposited strains. EqPV-H DNA was found not only in hepatocytes but also in bile duct epithelium and Kupffer cells, particularly via ISH. To the best of our knowledge, this is the first case of EqPV-H-associated TD in Asia, providing the first clinical evidence for viral shedding from the mouth and nose, and identification of EqPV-H in the liver. This study contributes to a better understanding of the pathological features of EqPV-H-associated TD.<\/jats:p>","DOI":"10.3390\/v13101917","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T23:08:31Z","timestamp":1632784111000},"page":"1917","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["First Clinical Case of Equine Parvovirus-Hepatitis-Related Theiler\u2019s Disease in Asia"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-3619","authenticated-orcid":false,"given":"Jungho","family":"Yoon","sequence":"first","affiliation":[{"name":"Equine Clinic, Jeju Stud Farm, Korea Racing Authority, Jeju 63346, Korea"},{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-6048","authenticated-orcid":false,"given":"Taemook","family":"Park","sequence":"additional","affiliation":[{"name":"Equine Clinic, Jeju Stud Farm, Korea Racing Authority, Jeju 63346, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahram","family":"Kim","sequence":"additional","affiliation":[{"name":"Equine Clinic, Jeju Stud Farm, Korea Racing Authority, Jeju 63346, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Equine Clinic, Jeju Stud Farm, Korea Racing Authority, Jeju 63346, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Seop","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon-Jeong","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-8559","authenticated-orcid":false,"given":"Dong-Hwi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7049-5510","authenticated-orcid":false,"given":"Soontag","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong 17546, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeeun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong 17546, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong-Bok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4158-6402","authenticated-orcid":false,"given":"Chang-Seon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"ref_1","unstructured":"Theiler, A. 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