{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:50:04Z","timestamp":1793908204451,"version":"4.8.0"},"reference-count":145,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one of the prominent public health problems in tropical and subtropical regions with no effective vaccines. Every year around 400 million people get infected by the Dengue virus, with a mortality rate of about 20% among the patients with severe dengue. The Dengue virus belongs to the Flaviviridae family, and it is an enveloped virus with positive-sense single-stranded RNA as the genetic material. Studies of the infection cycle of this virus revealed potential host targets important for the virus replication cycle. Here in this review article, we will be discussing different stages of the Dengue virus infection cycle inside mammalian host cells and how host proteins are exploited by the virus in the course of infection as well as how the host counteracts the virus by eliciting different antiviral responses.<\/jats:p>","DOI":"10.3390\/v13101967","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:59:47Z","timestamp":1633917587000},"page":"1967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":156,"title":["Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses"],"prefix":"10.3390","volume":"13","author":[{"given":"Nikita","family":"Nanaware","sequence":"first","affiliation":[{"name":"Division of Virology, ICMR-National AIDS Research Institute, Pune 411026, MH, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwesha","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Virology, ICMR-National AIDS Research Institute, Pune 411026, MH, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satarupa","family":"Mullick Bagchi","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-4966","authenticated-orcid":false,"given":"Parikshit","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0612-2258","authenticated-orcid":false,"given":"Anupam","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Division of Virology, ICMR-National AIDS Research Institute, Pune 411026, MH, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"ref_1","unstructured":"WHO (2021). Dengue and Severe Dengue, WHO."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Roy, S.K., and Bhattacharjee, S. (2021). Dengue virus: Epidemiology, biology, and disease aetiology. Can. J. Microbiol., 1\u201316.","DOI":"10.1139\/cjm-2020-0572"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11122","DOI":"10.1128\/JVI.01096-16","article-title":"Protective Capacity of the Human Anamnestic Antibody Response during Acute Dengue Virus Infection","volume":"90","author":"Xu","year":"2016","journal-title":"J. Virol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mjafi.2014.09.011","article-title":"Discovery of fifth serotype of dengue virus (DENV-5): A new public health dilemma in dengue control","volume":"71","author":"Mustafa","year":"2015","journal-title":"Med. J. Armed Forces India"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Harapan, H., Michie, A., Sasmono, R.T., and Imrie, A. (2020). Dengue: A Minireview. Viruses, 12.","DOI":"10.3390\/v12080829"},{"key":"ref_6","unstructured":"Murugesan, A., and Manoharan, M. (2020). Emerging and Reemerging Viral Pathogens, Elsevier."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1080\/22221751.2021.1944789","article-title":"Potential role of vector-mediated natural selection in dengue virus genotype\/lineage replacements in two epidemiologically contrasted settings","volume":"10","author":"Ou","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-385034-8.00001-6","article-title":"Recent Developments in Understanding Dengue Virus Replication","volume":"77","author":"Torres","year":"2010","journal-title":"Adv. Virus Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/femsre\/fuu004","article-title":"Receptors and routes of dengue virus entry into the host cells","volume":"39","author":"Freire","year":"2015","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Begum, F., Das, S., Mukherjee, D., and Ray, U. (2019). Hijacking the Host Immune Cells by Dengue Virus: Molecular Interplay of Receptors and Dengue Virus Envelope. Microorganisms, 7.","DOI":"10.20944\/preprints201908.0057.v1"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-800098-4.00001-5","article-title":"Revisiting Dengue Virus\u2013Host Cell Interaction: New insights into molecular and cellular virology","volume":"88","author":"Acosta","year":"2014","journal-title":"Adv. Virus Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Carro, S.D., and Cherry, S. (2020). Beyond the Surface: Endocytosis of Mosquito-Borne Flaviviruses. Viruses, 13.","DOI":"10.3390\/v13010013"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1126\/science.1153263","article-title":"The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and Maturation","volume":"319","author":"Li","year":"2008","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zaitseva, E., Yang, S.-T., Melikov, K., Pourmal, S., and Chernomordik, L.V. (2010). Dengue Virus Ensures Its Fusion in Late Endosomes Using Compartment-Specific Lipids. PLOS Pathog., 6.","DOI":"10.1371\/journal.ppat.1001131"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/bs.aivir.2020.08.003","article-title":"Structure-guided paradigm shifts in flavivirus assembly and maturation mechanisms","volume":"Volume 108","author":"Nicholls","year":"2020","journal-title":"Advances in Virus Research"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1128\/jvi.71.4.3244-3249.1997","article-title":"Dengue virus replication in human hepatoma cells activates NF-kappaB which in turn induces apoptotic cell death","volume":"71","author":"Marianneau","year":"1997","journal-title":"J. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.celrep.2019.04.051","article-title":"The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection","volume":"27","author":"Lin","year":"2019","journal-title":"Cell Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e48469","DOI":"10.7554\/eLife.48469","article-title":"The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins","volume":"8","author":"Ngo","year":"2019","journal-title":"eLife"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9711","DOI":"10.1038\/s41598-019-45910-9","article-title":"Dual roles for the ER membrane protein complex in flavivirus infection: Viral entry and protein biogenesis","volume":"9","author":"Barrows","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e01766-17","DOI":"10.1128\/JVI.01766-17","article-title":"Dengue Virus Selectively Annexes Endoplasmic Reticulum-Associated Translation Machinery as a Strategy for Co-opting Host Cell Protein Synthesis","volume":"92","author":"Reid","year":"2018","journal-title":"J. Virol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1101\/gad.12.15.2293","article-title":"Switch from translation to RNA replication in a positive-stranded RNA virus","volume":"12","author":"Gamarnik","year":"1998","journal-title":"Genes Dev."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Van den Elsen, K., Quek, J., and Luo, D. (2021). Molecular Insights into the Flavivirus Replication Complex. Viruses, 13.","DOI":"10.3390\/v13060956"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.chom.2009.03.007","article-title":"Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites","volume":"5","author":"Welsch","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1038\/s41467-021-22846-1","article-title":"Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase","volume":"12","author":"Lee","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5745","DOI":"10.1128\/JVI.02343-10","article-title":"The F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis","volume":"85","author":"Iglesias","year":"2011","journal-title":"J. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1128\/JVI.79.11.6631-6643.2005","article-title":"Long-Range RNA-RNA Interactions Circularize the Dengue Virus Genome","volume":"79","author":"Alvarez","year":"2005","journal-title":"J. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Choi, K. (2021). The Role of the Stem-Loop A RNA Promoter in Flavivirus Replication. Viruses, 13.","DOI":"10.3390\/v13061107"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.tibs.2020.12.007","article-title":"Molecular Determinants of Flavivirus Virion Assembly","volume":"46","author":"Barnard","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.chom.2019.09.015","article-title":"Dengue NS2A Protein Orchestrates Virus Assembly","volume":"26","author":"Xie","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1128\/JVI.02447-07","article-title":"Yellow Fever Virus NS3 Plays an Essential Role in Virus Assembly Independent of Its Known Enzymatic Functions","volume":"82","author":"Patkar","year":"2008","journal-title":"J. Virol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1128\/JVI.03351-14","article-title":"A Basic Cluster in the N Terminus of Yellow Fever Virus NS2A Contributes to Infectious Particle Production","volume":"89","author":"Wieseler","year":"2015","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-virology-110615-042334","article-title":"Properties and Functions of the Dengue Virus Capsid Protein","volume":"3","author":"Byk","year":"2016","journal-title":"Annu. Rev. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/sj.emboj.7600064","article-title":"Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation","volume":"23","author":"Bressanelli","year":"2004","journal-title":"EMBO J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8475","DOI":"10.1128\/jvi.71.11.8475-8481.1997","article-title":"Proteolytic activation of tick-borne encephalitis virus by furin","volume":"71","author":"Stadler","year":"1997","journal-title":"J. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1128\/jvi.63.6.2521-2526.1989","article-title":"Cell-associated West Nile flavivirus is covered with E+pre-M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release","volume":"63","author":"Wengler","year":"1989","journal-title":"J. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"12101","DOI":"10.1128\/JVI.01637-09","article-title":"Association of the pr Peptides with Dengue Virus at Acidic pH Blocks Membrane Fusion","volume":"83","author":"Yu","year":"2009","journal-title":"J. Virol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2008.06.041","article-title":"Novel binding between pre-membrane protein and vacuolar ATPase is required for efficient dengue virus secretion","volume":"373","author":"Duan","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbrc.2008.12.070","article-title":"Interaction of dengue virus envelope protein with endoplasmic reticulum-resident chaperones facilitates dengue virus production","volume":"379","author":"Limjindaporn","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.mib.2008.06.004","article-title":"Structural proteomics of dengue virus","volume":"11","author":"Perera","year":"2008","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1126\/science.1153264","article-title":"Structure of the Immature Dengue Virus at Low pH Primes Proteolytic Maturation","volume":"319","author":"Yu","year":"2008","journal-title":"Science"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0042-6822(91)90034-9","article-title":"Japanese encephalitis virus-vaccinia recombinants produce particulate forms of the structural membrane proteins and induce high levels of protection against lethal JEV infection","volume":"180","author":"Mason","year":"1991","journal-title":"Virology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nrmicro3030","article-title":"Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis","volume":"11","author":"John","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/infdis\/128.1.23","article-title":"Studies on the Pathogenesis of Dengue Infection in Monkeys. III. Sequential Distribution of Virus in Primary and Heterologous Infections","volume":"128","author":"Marchette","year":"1973","journal-title":"J. Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.1016\/j.vaccine.2011.07.022","article-title":"The pathogenesis of dengue","volume":"29","author":"Whitehorn","year":"2011","journal-title":"Vaccine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(07)61687-0","article-title":"Dengue","volume":"370","author":"Halstead","year":"2007","journal-title":"Lancet"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev.micro.62.081307.163005","article-title":"Global Spread and Persistence of Dengue","volume":"62","author":"Kyle","year":"2008","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"509306","DOI":"10.1155\/2015\/509306","article-title":"Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs","volume":"2015","author":"Aloia","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9877","DOI":"10.1128\/JVI.76.19.9877-9887.2002","article-title":"Activation of Terminally Differentiated Human Monocytes\/Macrophages by Dengue Virus: Productive Infection, Hierarchical Production of Innate Cytokines and Chemokines, and the Synergistic Effect of Lipopolysaccharide","volume":"76","author":"Chen","year":"2002","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/jmv.10340","article-title":"Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers","volume":"69","author":"Carr","year":"2003","journal-title":"J. Med Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.166.3.1499","article-title":"Infection of Human Dendritic Cells by Dengue Virus Causes Cell Maturation and Cytokine Production","volume":"166","author":"Ho","year":"2001","journal-title":"J. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.embor.7400814","article-title":"Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction","volume":"7","author":"Luplerdlop","year":"2006","journal-title":"EMBO Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.virol.2012.09.038","article-title":"Essential role of RIG-I in the activation of endothelial cells by dengue virus","volume":"435","author":"Rust","year":"2013","journal-title":"Virology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1089\/jir.2014.0195","article-title":"Dengue Virus Infection of Primary Endothelial Cells Induces Innate Immune Responses, Changes in Endothelial Cells Function and Is Restricted by Interferon-Stimulated Responses","volume":"35","author":"Calvert","year":"2015","journal-title":"J. Interf. Cytokine Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1099\/vir.0.028159-0","article-title":"Tumour necrosis factor alpha (TNF-\u03b1) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-\u03b1 to activate nuclear factor B and reduced sphingosine kinase-1 activity","volume":"92","author":"Wati","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/jpri\/2021\/v33i631185","article-title":"Dengue Virus: Infection, Immunological Response, and Vaccine Development","volume":"33","author":"Sindi","year":"2021","journal-title":"J. Pharm. Res. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.3389\/fimmu.2018.03007","article-title":"Neutrophil Activation and Early Features of NET Formation Are Associated with Dengue Virus Infection in Human","volume":"9","author":"Opasawatchai","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jconrel.2019.10.007","article-title":"MicroRNA delivery through nanoparticles","volume":"313","author":"Lee","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3892\/mmr.2013.1288","article-title":"microRNA expression profiling and bioinformatic analysis of dengue virus-infected peripheral blood mononuclear cells","volume":"7","author":"Qi","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/0004563215604001","article-title":"microRNA expression in blood of dengue patients","volume":"53","author":"Tambyah","year":"2016","journal-title":"Ann. Clin. Biochem. Int. J. Lab. Med."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zhu, X., He, Z., Hu, Y., Wen, W., Lin, C., Yu, J., Pan, J., Li, R., Deng, H., and Liao, S. (2014). MicroRNA-30e* Suppresses Dengue Virus Replication by Promoting NF-\u03baB\u2013Dependent IFN Production. PLoS Neglected Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003088"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.devcel.2008.07.008","article-title":"miR-126 Regulates Angiogenic Signaling and Vascular Integrity","volume":"15","author":"Fish","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1161\/HYPERTENSIONAHA.112.197301","article-title":"Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase","volume":"60","author":"Sun","year":"2012","journal-title":"Hypertension"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1073\/pnas.0707493105","article-title":"MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1","volume":"105","author":"Harris","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.gene.2015.04.014","article-title":"MicroRNA-221 regulates endothelial nitric oxide production and inflammatory response by targeting adiponectin receptor 1","volume":"565","author":"Chen","year":"2015","journal-title":"Gene"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000501209","article-title":"The Involvement of Neuroinflammation in Dengue Viral Disease: Importance of Innate and Adaptive Immunity","volume":"26","author":"Niranjan","year":"2019","journal-title":"Neuroimmunomodulation"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"27670","DOI":"10.1038\/srep27670","article-title":"Microglia retard dengue virus-induced acute viral encephalitis","volume":"6","author":"Tsai","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Al-Shujairi, W.H., Clarke, J.N., Davies, L.T., Alsharifi, M., Pitson, S., and Carr, J. (2017). Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169814"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/path.5013","article-title":"Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis","volume":"244","author":"Singh","year":"2018","journal-title":"J. Pathol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3014","article-title":"Immunity to dengue virus: A tale of original antigenic sin and tropical cytokine storms","volume":"11","author":"Rothman","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0092-8674(01)00456-1","article-title":"Dendritic Cell Subsets and Lineages, and Their Functions in Innate and Adaptive Immunity","volume":"106","author":"Liu","year":"2001","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Cerny, D., Haniffa, M., Shin, A., Bigliardi, P.L., Tan, B.K., Lee, B., Poidinger, M., Tan, E.Y., Ginhoux, F., and Fink, K. (2014). Selective Susceptibility of Human Skin Antigen Presenting Cells to Productive Dengue Virus Infection. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004548"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1128\/JVI.78.6.2701-2710.2004","article-title":"Interferon-Dependent Immunity Is Essential for Resistance to Primary Dengue Virus Infection in Mice, Whereas T- and B-Cell-Dependent Immunity Are Less Critical","volume":"78","author":"Shresta","year":"2004","journal-title":"J. Virol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Nascimento, E.J.M., Silva, A.M., Cordeiro, M.T., Brito, C.A., Gil, L.H.V.G., Braga-Neto, U., and Marques, E.T.A. (2009). Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006782"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-Stimulated Genes: A Complex Web of Host Defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jmb.2013.11.023","article-title":"Innate Immunity to Dengue Virus Infection and Subversion of Antiviral Responses","volume":"426","author":"Green","year":"2014","journal-title":"J. Mol. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Nasirudeen, A.M.A., Wong, H.H., Thien, P., Xu, S., Lam, K.-P., and Liu, D.X. (2011). RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection. PLoS Neglected Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0000926"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1093\/infdis\/jir607","article-title":"B-Cell Responses During Primary and Secondary Dengue Virus Infections in Humans","volume":"204","author":"Mathew","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1086\/651018","article-title":"Mechanisms of Immune Evasion Induced by a Complex of Dengue Virus and Preexisting Enhancing Antibodies","volume":"201","author":"Ubol","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3389\/fimmu.2016.00531","article-title":"Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection","volume":"7","author":"Tian","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.3389\/fimmu.2019.02125","article-title":"Human T Cell Response to Dengue Virus Infection","volume":"10","author":"Tian","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_81","first-page":"172","article-title":"Cytokine patterns during dengue shock syndrome","volume":"14","author":"Suharti","year":"2003","journal-title":"Eur. Cytokine Netw."},{"key":"ref_82","first-page":"25","article-title":"Circulating levels of tumour necrosis factor-alpha & interferon-gamma in patients with dengue & dengue haemorrhagic fever during an outbreak","volume":"123","author":"Chakravarti","year":"2006","journal-title":"Indian J. Med Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Bozza, F.A., Cruz, O.G., Zagne, S.M., Azeredo, E.L., Nogueira, R.M., Assis, E.F., Bozza, P.T., and Kubelka, C.F. (2008). Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity. BMC Infect. Dis., 8.","DOI":"10.1186\/1471-2334-8-86"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00281-017-0625-1","article-title":"Immune-mediated cytokine storm and its role in severe dengue","volume":"39","author":"Srikiatkhachorn","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1423-0127-20-40","article-title":"An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection","volume":"20","author":"Tsai","year":"2013","journal-title":"J. Biomed. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/0377-4929.200027","article-title":"Association of interleukin-2, -4 and -10 with dengue severity","volume":"60","author":"Abhishek","year":"2017","journal-title":"Indian J. Pathol. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/jir.2017.0037","article-title":"Highlights for Dengue Immunopathogenesis: Antibody-Dependent Enhancement, Cytokine Storm, and Beyond","volume":"38","author":"Kuczera","year":"2018","journal-title":"J. Interf. Cytokine Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"28768","DOI":"10.1038\/srep28768","article-title":"How antibodies alter the cell entry pathway of dengue virus particles in macrophages","volume":"6","author":"Nunez","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1073\/pnas.1317454111","article-title":"Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue","volume":"111","author":"Chan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Viktorovskaya, O.V., Greco, T.M., Cristea, I.M., and Thompson, S.R. (2016). Identification of RNA Binding Proteins Associated with Dengue Virus RNA in Infected Cells Reveals Temporally Distinct Host Factor Requirements. PLoS Neglected Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004921"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e00528-19","DOI":"10.1128\/mSphere.00528-19","article-title":"Antibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced Infection","volume":"4","author":"Chan","year":"2019","journal-title":"mSphere"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"580096","DOI":"10.3389\/fcimb.2020.580096","article-title":"Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection","volume":"10","author":"Narayan","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/ni.1771","article-title":"TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis","volume":"10","author":"Kawagoe","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/tra.12012","article-title":"Molecular Mechanisms Involved in Antibody-Dependent Enhancement of Dengue Virus Infection in Humans","volume":"14","author":"Flipse","year":"2012","journal-title":"Traffic"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Malavige, G., Huang, L.-C., Salimi, M., Gomes, L., Jayaratne, S.D., and Ogg, G.S. (2012). Cellular and Cytokine Correlates of Severe Dengue Infection. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050387"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"29201","DOI":"10.1038\/srep29201","article-title":"Antibody-Dependent Enhancement of Dengue Virus Infection in Primary Human Macrophages; Balancing Higher Fusion against Antiviral Responses","volume":"6","author":"Flipse","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"654494","DOI":"10.3389\/fmicb.2021.654494","article-title":"The Dual Regulation of Apoptosis by Flavivirus","volume":"12","author":"Pan","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.virusres.2009.11.012","article-title":"Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis","volume":"147","author":"Netsawang","year":"2010","journal-title":"Virus Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.virusres.2010.12.012","article-title":"Cell death gene expression profile: Role of RIPK2 in dengue virus-mediated apoptosis","volume":"156","author":"Morchang","year":"2011","journal-title":"Virus Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.micinf.2008.06.005","article-title":"Induction of p53-dependent and mitochondria-mediated cell death pathway by dengue virus infection of human and animal cells","volume":"10","author":"Nasirudeen","year":"2008","journal-title":"Microbes Infect."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1096\/fj.12-213967","article-title":"XAF1 contributes to dengue virus-induced apoptosis in vascular endothelial cells","volume":"27","author":"Long","year":"2013","journal-title":"FASEB J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.bbadis.2007.08.003","article-title":"Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus","volume":"1772","author":"Midlej","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1590\/S0074-02762009000800005","article-title":"Dengue-2 infection and the induction of apoptosis in human primary monocytes","volume":"104","author":"Azeredo","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1089\/vim.2016.0092","article-title":"Immunopathogenesis of Dengue Virus-Induced Redundant Cell Death: Apoptosis and Pyroptosis","volume":"30","author":"Suwanmanee","year":"2017","journal-title":"Viral Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Thepparit, C., Khakpoor, A., Khongwichit, S., Wikan, N., Fongsaran, C., Chingsuwanrote, P., Panraksa, P., and Smith, D.R. (2013). Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death. BMC Res. Notes, 6.","DOI":"10.1186\/1756-0500-6-372"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bbrc.2014.07.016","article-title":"Dengue virus disrupts Daxx and NF-\u03baB interaction to induce CD137-mediated apoptosis","volume":"450","author":"Netsawang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_107","first-page":"41","article-title":"NF-\u03baB, an Evolutionarily Conserved Mediator of Immune and Inflammatory Responses","volume":"560","author":"Xiao","year":"2005","journal-title":"Mech. Lymph. Act. Immune Regul. X"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Olagnier, D., Peri, S., Steel, C., Van Montfoort, N., Chiang, C., Beljanski, V., Slifker, M., He, Z., Nichols, C.N., and Lin, R. (2014). Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004566"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"657","DOI":"10.4049\/jimmunol.169.2.657","article-title":"Endothelial Cell Apoptosis Induced by Antibodies Against Dengue Virus Nonstructural Protein 1 Via Production of Nitric Oxide","volume":"169","author":"Lin","year":"2002","journal-title":"J. Immunol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Morchang, A., Lee, R.C.H., Yenchitsomanus, P.-T., Sreekanth, G.P., Noisakran, S., Chu, J.J.H., and Limjindaporn, T. (2017). RNAi screen reveals a role of SPHK2 in dengue virus\u2013mediated apoptosis in hepatic cell lines. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188121"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"467","DOI":"10.18632\/oncotarget.293","article-title":"Phosphorylation of AKT: A Mutational Analysis","volume":"2","author":"Hart","year":"2011","journal-title":"Oncotarget"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.virol.2018.01.009","article-title":"Expression of flavivirus capsids enhance the cellular environment for viral replication by activating Akt-signalling pathways","volume":"516","author":"Airo","year":"2018","journal-title":"Virology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.bbrc.2012.01.050","article-title":"Dengue virus utilizes calcium modulating cyclophilin-binding ligand to subvert apoptosis","volume":"418","author":"Li","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.virol.2011.07.010","article-title":"Induced autophagy reduces virus output in dengue infected monocytic cells","volume":"418","author":"Panyasrivanit","year":"2011","journal-title":"Virology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.virol.2008.02.016","article-title":"Autophagic machinery activated by dengue virus enhances virus replication","volume":"374","author":"Lee","year":"2008","journal-title":"Virology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1074\/jbc.M112.412783","article-title":"XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation","volume":"288","author":"Margariti","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4269\/ajtmh.18-0761","article-title":"Significance of Autophagy in Dengue Virus Infection: A Brief Review","volume":"100","author":"Acharya","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e2127","DOI":"10.1038\/cddis.2015.409","article-title":"Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation","volume":"7","author":"Datan","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41598-017-18909-3","article-title":"Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.1128\/JVI.00787-15","article-title":"Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62","volume":"89","author":"Metz","year":"2015","journal-title":"J. Virol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4103\/1995-7645.257113","article-title":"Herbal remedies, vaccines and drugs for dengue fever: Emerging prevention and treatment strategies","volume":"12","author":"Verma","year":"2019","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1002\/ptr.6917","article-title":"A systematic review on phytochemicals for the treatment of dengue","volume":"35","author":"Ali","year":"2020","journal-title":"Phytotherapy Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1080\/21645515.2019.1658503","article-title":"A review of Dengvaxia\u00ae: Development to deployment","volume":"15","author":"Thomas","year":"2019","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chom.2020.12.011","article-title":"Dengue Vaccines: The Promise and Pitfalls of Antibody-Mediated Protection","volume":"29","author":"Martinez","year":"2021","journal-title":"Cell Host Microbe"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41467-021-21384-0","article-title":"A tetravalent live attenuated dengue virus vaccine stimulates balanced immunity to multiple serotypes in humans","volume":"12","author":"Nivarthi","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e02482-20","DOI":"10.1128\/JVI.02482-20","article-title":"A Dengue Virus Serotype 1 mRNA-LNP Vaccine Elicits Protective Immune Responses","volume":"95","author":"Wollner","year":"2021","journal-title":"J. Virol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S2221-1691(13)60057-X","article-title":"RNAi: Antiviral therapy against dengue virus","volume":"3","author":"Idrees","year":"2013","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12985-019-1127-7","article-title":"Efficacy of geraniin on dengue virus type-2 infected BALB\/c mice","volume":"16","author":"Ahmad","year":"2019","journal-title":"Virol. J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.2147\/IDR.S210890","article-title":"Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies","volume":"12","author":"Dominguez","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/ptr.6562","article-title":"Diterpenes and their derivatives as promising agents against dengue virus and dengue vectors: A literature-based review","volume":"34","author":"Islam","year":"2019","journal-title":"Phytotherapy Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-2478(96)02620-X","article-title":"Enhanced TNF\u03b1 production by monocytic-like cells exposed to dengue virus antigens","volume":"53","author":"Hober","year":"1996","journal-title":"Immunol. Lett."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5897\/JMPR11.1046","article-title":"In vitro antiviral activity of fisetin, rutin and naringenin against dengue virus type-2","volume":"8","author":"Keivan","year":"2014","journal-title":"J. Med. Plants Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s12906-019-2695-1","article-title":"In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting","volume":"19","author":"Robledo","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00705-018-3769-y","article-title":"Inhibitory effect of the green tea molecule EGCG against dengue virus infection","volume":"163","author":"Raekiansyah","year":"2018","journal-title":"Arch. Virol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Loaiza-Cano, V., Monsalve-Escudero, L.M., Filho, C.d.S.M.B., Martinez-Gutierrez, M., and de Sousa, D.P. (2020). Antiviral Role of Phenolic Compounds against Dengue Virus: A Review. Biomolecules, 11.","DOI":"10.3390\/biom11010011"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jmv.24660","article-title":"Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay","volume":"89","author":"Han","year":"2017","journal-title":"J. Med Virol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.antiviral.2014.07.002","article-title":"Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus","volume":"109","author":"Syed","year":"2014","journal-title":"Antivir. Res."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Chen, T.-Y., Chen, D.-Y., Wen, H.-W., Ou, J.-L., Chiou, S.-S., Chen, J.-M., Wong, M.-L., and Hsu, W.-L. (2013). Inhibition of Enveloped Viruses Infectivity by Curcumin. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062482"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1007\/s00705-016-3034-1","article-title":"Salidroside exhibits anti-dengue virus activity by upregulating host innate immune factors","volume":"161","author":"Sharma","year":"2016","journal-title":"Arch. Virol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/aps.2015.56","article-title":"Policresulen, a novel NS2B\/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells","volume":"36","author":"Wu","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.3390\/v7092852","article-title":"Honokiol, a Lignan Biphenol Derived from the Magnolia Tree, Inhibits Dengue Virus Type 2 Infection","volume":"7","author":"Fang","year":"2015","journal-title":"Viruses"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.foodchem.2016.07.102","article-title":"Facile preparation of water soluble curcuminoids extracted from turmeric (Curcuma longa L.) powder by using steviol glucosides","volume":"214","author":"Nguyen","year":"2017","journal-title":"Food Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1002\/chem.201900591","article-title":"Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon","volume":"25","author":"Tan","year":"2019","journal-title":"Chem. Eur. J."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.antiviral.2018.04.013","article-title":"Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation","volume":"154","author":"Peng","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/26895293.2020.1856192","article-title":"Recent insights on anti-dengue virus (DENV) medicinal plants: Review on in vitro, in vivo and in silico discoveries","volume":"14","author":"Lim","year":"2021","journal-title":"All Life"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/10\/1967\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:07:58Z","timestamp":1760166478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/10\/1967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":145,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["v13101967"],"URL":"https:\/\/doi.org\/10.3390\/v13101967","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,30]]}}}