{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:29:19Z","timestamp":1768314559024,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>With the emerging success of the COVID-19 vaccination programs, the incidence of acute COVID-19 will decrease. However, given the high number of people who contracted SARS-CoV-2 infection and recovered, we will be faced with a significant number of patients with persistent symptoms even months after their COVID-19 infection. In this setting, long COVID and its cardiovascular manifestations, including pericarditis, need to become a top priority for healthcare systems as a new chronic disease process. Concerning the relationship between COVID-19 and pericardial diseases, pericarditis appears to be common in the acute infection but rare in the postacute period, while small pericardial effusions may be relatively common in the postacute period of COVID-19. Here, we reported a series of 7 patients developing pericarditis after a median of 20 days from clinical and virological recovery from SARS-CoV-2 infection. We excluded specific identifiable causes of pericarditis, hence we speculate that these cases can be contextualized within the clinical spectrum of long COVID. All our patients were treated with a combination of colchicine and either ASA or NSAIDs, but four of them did not achieve a clinical response. When switched to glucocorticoids, these four patients recovered with no recurrence during drug tapering. Based on this observation and on the latency of pericarditis occurrence (a median of 20 days after a negative nasopharyngeal swab), could be suggested that post-COVID pericarditis may be linked to ongoing inflammation sustained by the persistence of viral nucleic acid without virus replication in the pericardium. Therefore, glucocorticoids may be a suitable treatment option in patients not responding or intolerant to conventional therapy and who require to counteract the pericardial inflammatory component rather than direct an acute viral injury to the pericardial tissue.<\/jats:p>","DOI":"10.3390\/v13101997","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:59:47Z","timestamp":1633917587000},"page":"1997","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pericarditis after SARS-CoV-2 Infection: Another Pebble in the Mosaic of Long COVID?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-5136","authenticated-orcid":false,"given":"Francesco","family":"Carubbi","sequence":"first","affiliation":[{"name":"Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"},{"name":"Department of Medicine, ASL 1 Avezzano-Sulmona-L\u2019Aquila, San Salvatore Hospital, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1105-5640","authenticated-orcid":false,"given":"Alessia","family":"Alunno","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Leone","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Di Gregorio","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"},{"name":"Department of Medicine, ASL 1 Avezzano-Sulmona-L\u2019Aquila, San Salvatore Hospital, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardina","family":"Mancini","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"},{"name":"Department of Medicine, ASL 1 Avezzano-Sulmona-L\u2019Aquila, San Salvatore Hospital, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-3758","authenticated-orcid":false,"given":"Angelo","family":"Viscido","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-0655","authenticated-orcid":false,"given":"Rita","family":"Del Pinto","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Cicogna","sequence":"additional","affiliation":[{"name":"Department of Medicine, ASL 1 Avezzano-Sulmona-L\u2019Aquila, San Salvatore Hospital, 67100 L\u2019Aquila, Italy"},{"name":"Cardiology and Coronary Care Unit, San Salvatore Hospital, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Grassi","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Ferri","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Unit, Department of Life, Health & Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19765","DOI":"10.1038\/s41598-020-74988-9","article-title":"Clinical presentations, laboratory and radiological findings, and treatments for 11,028 COVID-19 patients: A systematic review and meta-analysis","volume":"10","author":"Wong","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/annrheumdis-2020-219724","article-title":"EULAR points to consider on pathophysiology and use of immunomodulatory therapies in COVID-19","volume":"80","author":"Alunno","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1038\/s41598-021-83831-8","article-title":"Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: Data from two Italian COVID-19 units","volume":"11","author":"Carubbi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s40292-020-00429-3","article-title":"Clinical Characteristics and Outcomes of Patients with COVID-19 Infection: The Results of the SARS-RAS Study of the Italian Society of Hypertension","volume":"28","author":"Mancusi","year":"2021","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref_5","unstructured":"National Institute for Health and Care Excellence (2021, September 03). COVID-19 Rapid Guideline: Managing the Long-Term Effects of COVID-19. Available online: https:\/\/bit.ly\/3BBHRip."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41591-021-01292-y","article-title":"Attributes and predictors of long COVID","volume":"27","author":"Sudre","year":"2021","journal-title":"Nat. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","article-title":"6-month consequences of COVID-19 in patients discharged from hospital: A cohort study","volume":"397","author":"Huang","year":"2021","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ramadan, M.S., Bertolino, L., Marrazzo, T., Florio, M.T., and Durante-Mangoni, E. (2021). The Monaldi Hospital Cardiovascular Infection Study Group. Cardiac complications during the active phase of COVID-19: Review of the current evidence. Intern. Emerg. Med., 1\u201311.","DOI":"10.1007\/s11739-021-02763-3"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1271e3","DOI":"10.1161\/CIRCULATIONAHA.120.051362","article-title":"An urgent need for studies of the late effects of SARS-CoV-2 on the cardiovascular system","volume":"143","author":"Maleszewski","year":"2021","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1016\/j.jcmg.2020.05.004","article-title":"Cardiac Involvement in Patients Recovered from COVID-2019 Identified Using Magnetic Resonance Imaging","volume":"13","author":"Huang","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1093\/eurheartj\/ehab075","article-title":"Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance","volume":"42","author":"Kotecha","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.cmi.2021.06.015","article-title":"Cardiac sequelae after coronavirus disease 2019 recovery: A systematic review","volume":"27","author":"Ramadan","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/thoraxjnl-2020-215861","article-title":"Identifying patients at risk of post-discharge complications related to COVID-19 infection","volume":"76","author":"Hall","year":"2021","journal-title":"Thorax"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"n1648","DOI":"10.1136\/bmj.n1648","article-title":"Long covid-mechanisms, risk factors, and management","volume":"374","author":"Crook","year":"2021","journal-title":"BMJ"},{"key":"ref_15","first-page":"100025","article-title":"Post-Acute COVID-19 Syndrome and the cardiovascular system: What is known?","volume":"5","author":"Dixit","year":"2021","journal-title":"Am. Heart J. Plus."},{"key":"ref_16","unstructured":"WHO Working Group on the Clinical Characterisation and Management of COVID-19 Infection (2020). A minimal common outcome measure set for COVID-19 clinical research. Lancet Infect. Dis., 20, e192\u2013e197."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1093\/eurheartj\/ehv318","article-title":"2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS)","volume":"36","author":"Adler","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/hrt.2006.104067","article-title":"Myopericarditis versus viral or idiopathic acute pericarditis","volume":"94","author":"Imazio","year":"2007","journal-title":"Heart"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1161\/CIRCULATIONAHA.105.542738","article-title":"Colchicine in addition to conventional therapy for acute pericarditis: Results of the COlchicine for acute PEricarditis (COPE) trial","volume":"112","author":"Imazio","year":"2005","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1056\/NEJMoa1208536","article-title":"A Randomized Trial of Colchicine for Acute Pericarditis","volume":"369","author":"Imazio","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e018950","DOI":"10.1161\/JAHA.120.018950","article-title":"US Database Study of Clinical Burden and Unmet Need in Recurrent Pericarditis","volume":"10","author":"Klein","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/01.JAA.0000615468.46936.6d","article-title":"Managing acute and recurrent idiopathic pericarditis","volume":"33","author":"Schwier","year":"2020","journal-title":"J. Am. Acad. Physician Assist."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1056\/NEJMcp1404070","article-title":"Clinical practice. Acute pericarditis","volume":"371","author":"LeWinter","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jacc.2003.09.055","article-title":"Day-hospital treatment of acute pericarditis: A management program for outpatient therapy","volume":"43","author":"Imazio","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10741-013-9382-y","article-title":"Pericardioscopy and epi- and pericardial biopsy\u2014A new window to the heart improving etiological diagnoses and permitting targeted intrapericardial therapy","volume":"18","author":"Maisch","year":"2013","journal-title":"Heart Fail. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/PL00001993","article-title":"Cytokine Activation in Pericardial Fluids in Different Forms of Pericarditis","volume":"25","author":"Pankuweit","year":"2000","journal-title":"Herz"},{"key":"ref_27","first-page":"345","article-title":"Pericardial cytokines in neoplastic, autoreactive, and viral pericarditis","volume":"18","author":"Pankuweit","year":"2012","journal-title":"Heart Fail. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"784.e1","DOI":"10.1016\/j.amjmed.2015.01.040","article-title":"Etiology of Pericarditis in a Prospective Cohort of 1162 Cases","volume":"128","author":"Gouriet","year":"2015","journal-title":"Am. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19","volume":"181","author":"Liu","year":"2020","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejim.2020.06.015","article-title":"Electrocardiographic features of patients with COVID-19 pneumonia","volume":"78","author":"Angeli","year":"2020","journal-title":"Eur. J. Intern. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1161\/CIRCULATIONAHA.120.052573","article-title":"COVID-19 Myocardial Pathology Evaluation in Athletes With Cardiac Magnetic Resonance (COMPETE CMR)","volume":"143","author":"Clark","year":"2021","journal-title":"Circulation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1001\/jamacardio.2021.0565","article-title":"Prevalence of Inflammatory Heart Disease Among Professional Athletes With Prior COVID-19 Infection Who Received Systematic Return-to-Play Cardiac Screening","volume":"6","author":"Martinez","year":"2021","journal-title":"JAMA Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/jamacardio.2020.3557","article-title":"Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)","volume":"5","author":"Puntmann","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jacc.2020.11.031","article-title":"Pathological evidence for SARS-CoV-2 as a cause of myocarditis: JACC review topic of the week","volume":"77","author":"Kawakami","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1093\/eurheartj\/ehaa664","article-title":"Pathological features of COVID-19-associated myocardial injury: A multicentre cardiovascular pathology study","volume":"41","author":"Basso","year":"2020","journal-title":"Eur. Hear. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1161\/CIRCULATIONAHA.108.844753","article-title":"Controversial Issues in the Management of Pericardial Diseases","volume":"121","author":"Imazio","year":"2010","journal-title":"Circulation"},{"key":"ref_38","first-page":"118","article-title":"Corticosteroid therapy for pericarditis: A double-edged sword","volume":"5","author":"Imazio","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2459\/JCM.0000000000001059","article-title":"Anti-inflammatory therapies for pericardial diseases in the COVID-19 pandemic: Safety and potentiality","volume":"21","author":"Imazio","year":"2020","journal-title":"J. Cardiovasc. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"993","DOI":"10.15585\/mmwr.mm6930e1","article-title":"Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network\u2014United States, March\u2013June 2020","volume":"69","author":"Tenforde","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_41","unstructured":"UK Office for National Statistics (2021, September 03). Prevalence of Long COVID Symptoms and COVID-19 Complications. Available online: https:\/\/bit.ly\/3BwD8yg."},{"key":"ref_42","first-page":"e13746","article-title":"Assessment and characterisation of post-COVID-19 manifestations","volume":"75","author":"Kamal","year":"2020","journal-title":"Int. J. Clin. Pract."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/10\/1997\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:09:29Z","timestamp":1760166569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/10\/1997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["v13101997"],"URL":"https:\/\/doi.org\/10.3390\/v13101997","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,4]]}}}