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Rotavirus, norovirus, and sapovirus are leading causes of childhood AGE. A successful rotavirus vaccine has reduced rotavirus hospitalizations by more than 50%. Using rotavirus as a guide, elucidating the determinants, breath, and duration of serological antibody immunity to AGE viruses, as well as host genetic factors that define susceptibility is essential for informing development of future vaccines and improving current vaccine candidates. Here, we summarize the current knowledge of disease burden and serological antibody immunity following natural infection to inform further vaccine development for these three high-burden viruses.<\/jats:p>","DOI":"10.3390\/v13102033","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:59:47Z","timestamp":1633917587000},"page":"2033","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Serological Humoral Immunity Following Natural Infection of Children with High Burden Gastrointestinal Viruses"],"prefix":"10.3390","volume":"13","author":[{"given":"Mark R.","family":"Zweigart","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Becker-Dreps","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA"},{"name":"Department of Family Medicine, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filem\u00f3n","family":"Bucardo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, National Autonomous University of Nicaragua, Le\u00f3n 21000, Nicaragua"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredman","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Microbiology, National Autonomous University of Nicaragua, Le\u00f3n 21000, Nicaragua"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-8701","authenticated-orcid":false,"given":"Ralph S.","family":"Baric","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-0522","authenticated-orcid":false,"given":"Lisa C.","family":"Lindesmith","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1309","DOI":"10.1016\/S2214-109X(18)30349-8","article-title":"Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: A reanalysis of the MAL-ED cohort study","volume":"6","author":"Liu","year":"2018","journal-title":"Lancet Glob. 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