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For example, dengue, Japanese encephalitis, West Nile, yellow fever, and Zika viruses are transmitted by infected mosquitoes and cause severe and fatal diseases in humans. The means by which mosquito-borne flaviviruses establish persistent infection in mosquitoes and cause disease in humans are complex and depend upon a myriad of virus-host interactions, such as those of the innate immune system, which are the main focus of our review. This review also covers the different strategies utilized by mosquito-borne flaviviruses to antagonize the innate immune response in humans and mosquitoes. Given the lack of antiviral therapeutics for mosquito-borne flaviviruses, improving our understanding of these virus-immune interactions could lead to new antiviral therapies and strategies for developing refractory vectors incapable of transmitting these viruses, and can also provide insights into determinants of viral tropism that influence virus emergence into new species.<\/jats:p>","DOI":"10.3390\/v13112116","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T22:07:04Z","timestamp":1634767624000},"page":"2116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6944-9971","authenticated-orcid":false,"given":"Ahmed M. 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Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-med-050715-105122","article-title":"Zika, Chikungunya, and Other Emerging Vector-Borne Viral Diseases","volume":"69","author":"Weaver","year":"2018","journal-title":"Annu. Rev. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrmicro1006","article-title":"Transmission cycles, host range, evolution and emergence of arboviral disease","volume":"2","author":"Weaver","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0065-3527(03)59002-9","article-title":"Molecular biology of flaviviruses","volume":"59","author":"Lindenbach","year":"2003","journal-title":"Adv. Virus Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1128\/jvi.67.4.2327-2335.1993","article-title":"Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A\/4B signalase site","volume":"67","author":"Lin","year":"1993","journal-title":"J. Virol."},{"key":"ref_7","unstructured":"Knipe, D.M., and Howley, P.M. (2013). Fields Virology, Wolters Kluwer Health. [6th ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.chom.2008.10.007","article-title":"A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity","volume":"4","author":"Pijlman","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ni1303","article-title":"Innate immune recognition of viral infection","volume":"7","author":"Kawai","year":"2006","journal-title":"Nat. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pt.2015.09.009","article-title":"Mosquito Defense Strategies against Viral Infection","volume":"32","author":"Cheng","year":"2016","journal-title":"Trends Parasitol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.3390\/v6114479","article-title":"Mosquito immunity against arboviruses","volume":"6","author":"Sim","year":"2014","journal-title":"Viruses"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1126\/science.1139862","article-title":"Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes","volume":"316","author":"Waterhouse","year":"2007","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-019-3433-8","article-title":"Mosquito antiviral defense mechanisms: A delicate balance between innate immunity and persistent viral infection","volume":"12","author":"Lee","year":"2019","journal-title":"Parasites Vectors"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cytogfr.2017.05.007","article-title":"Interaction of the innate immune system with positive-strand RNA virus replication organelles","volume":"37","author":"Scutigliani","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1038\/srep07395","article-title":"The dengue virus conceals double-stranded RNA in the intracellular membrane to escape from an interferon response","volume":"4","author":"Uchida","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.mib.2013.04.005","article-title":"An evolutionary perspective on the broad antiviral specificity of MxA","volume":"16","author":"Mitchell","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.virol.2013.10.005","article-title":"The West Nile virus assembly process evades the conserved antiviral mechanism of the interferon-induced MxA protein","volume":"448","author":"Hoenen","year":"2014","journal-title":"Virology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/ni.1979","article-title":"Ribose 2\u2032-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5","volume":"12","author":"Habjan","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.cell.2018.11.028","article-title":"Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis","volume":"175","author":"Shah","year":"2018","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/15548627.2016.1265192","article-title":"Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B","volume":"13","author":"Lennemann","year":"2017","journal-title":"Autophagy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/gbe\/evy066","article-title":"Signatures of DNA methylation across insects suggest reduced DNA methylation levels in holometabola","volume":"10","author":"Provataris","year":"2018","journal-title":"Genome Biol. Evol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Simmonds, P., Xia, W., Baillie, J.K., and McKinnon, K. (2013). Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla -selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses. BMC Genom., 14.","DOI":"10.1186\/1471-2164-14-610"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Colmant, A.M.G., Hobson-Peters, J., Slijkerman, T.A.P., Harrison, J.J., Pijlman, G.P., van Oers, M.M., Simmonds, P., Hall, R.A., and Fros, J.J. (2021). Insect-specific flavivirus replication in mammalian cells is inhibited by physiological temperature and the zinc-finger antiviral protein. Viruses, 13.","DOI":"10.20944\/preprints202102.0215.v1"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrmicro2950","article-title":"West Nile virus infection and immunity","volume":"11","author":"Suthar","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-immunol-042617-053142","article-title":"Immune Response to Dengue and Zika","volume":"36","author":"Ngono","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fimmu.2014.00342","article-title":"Pattern recognition and signaling mechanisms of RIG-I and MDA5","volume":"5","author":"Reikine","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhu, T., and Fernandez-Sesma, A. (2020). Innate immune DNA sensing of Flaviviruses. Viruses, 12.","DOI":"10.3390\/v12090979"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1038\/s41598-017-03932-1","article-title":"Dengue virus activates cGAS through the release of mitochondrial DNA","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cytogfr.2014.08.004","article-title":"Message in a bottle: Lessons learned from antagonism of STING signalling during RNA virus infection","volume":"25","author":"Maringer","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s12276-021-00602-1","article-title":"Innate immune sensing of coronavirus and viral evasion strategies","volume":"53","author":"Kasuga","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1061","article-title":"RIP1 is an essential mediator of Toll-like receptor 3-induced NF \u03baB activation","volume":"5","author":"Meylan","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Uno, N., and Ross, T.M. (2018). Dengue virus and the host innate immune response. Emerg. Microbes Infect., 7.","DOI":"10.1038\/s41426-018-0168-0"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1128\/JVI.05738-11","article-title":"Sensing of RNA Viruses: A Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion","volume":"86","author":"Jensen","year":"2012","journal-title":"J. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.virol.2005.07.021","article-title":"West Nile virus replication interferes with both poly(I:C)-induced interferon gene transcription and response to interferon treatment","volume":"342","author":"Scholle","year":"2005","journal-title":"Virology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.1128\/JVI.00226-08","article-title":"West Nile Virus Nonstructural Protein 1 Inhibits TLR3 Signal Transduction","volume":"82","author":"Wilson","year":"2008","journal-title":"J. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/viro.2002.1453","article-title":"Construction and characterization of subgenomic replicons of New York strain of West Nile virus","volume":"296","author":"Shi","year":"2002","journal-title":"Virology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1128\/JVI.80.6.2913-2923.2006","article-title":"West Nile Virus Evades Activation of Interferon Regulatory Factor 3 through RIG-I-Dependent and -Independent Pathways without Antagonizing Host Defense Signaling","volume":"80","author":"Fredericksen","year":"2006","journal-title":"J. Virol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.virol.2010.05.020","article-title":"Nonstructural NS1 proteins of several mosquito-borne Flavivirus do not inhibit TLR3 signaling","volume":"404","author":"Baronti","year":"2010","journal-title":"Virology"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Carbaugh, D.L., and Lazear, H.M. (2020). Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis. J. Virol., 94.","DOI":"10.1128\/JVI.00104-20"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1099\/vir.0.012120-0","article-title":"N-linked glycans on dengue viruses grown in mammalian and insect cells","volume":"90","author":"Hacker","year":"2009","journal-title":"J. Gen. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8403","DOI":"10.4049\/jimmunol.179.12.8403","article-title":"West Nile Virus Envelope Protein Inhibits dsRNA-Induced Innate Immune Responses","volume":"179","author":"Arjona","year":"2007","journal-title":"J. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05732","article-title":"TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity","volume":"446","author":"Gack","year":"2007","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.aab3369","article-title":"Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness","volume":"350","author":"Manokaran","year":"2015","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fimmu.2020.00051","article-title":"NS5 Conservative Site Is Required for Zika Virus to Restrict the RIG-I Signaling","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Donald, C.L., Brennan, B., Cumberworth, S.L., Rezelj, V.V., Clark, J.J., Cordeiro, M.T., Freitas de Oliveira Fran\u00e7a, R., Pena, L.J., Wilkie, G.S., and Da Silva Filipe, A. (2016). Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0005048"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1126\/science.1247749","article-title":"Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System","volume":"343","author":"Akey","year":"2014","journal-title":"Science"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.02396-16","article-title":"West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5","volume":"91","author":"Zhang","year":"2017","journal-title":"J. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.chom.2012.04.006","article-title":"The mitochondrial targeting chaperone 14-3-3\u03b5 regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity","volume":"11","author":"Liu","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/ni.3393","article-title":"A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity","volume":"17","author":"Chan","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.chom.2019.09.012","article-title":"Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity","volume":"26","author":"Riedl","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Yu, C.Y., Liang, J.J., Li, J.K., Lee, Y.L., Chang, B.L., Su, C.I., Huang, W.J., Lai, M.M.C., and Lin, Y.L. (2015). Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1005350"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Xia, H., Luo, H., Shan, C., Muruato, A.E., Nunes, B.T.D., Medeiros, D.B.A., Zou, J., Xie, X., Giraldo, M.I., and Vasconcelos, P.F.C. (2018). An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction. Nat. Commun., 9.","DOI":"10.1038\/s41467-017-02816-2"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.3389\/fmicb.2018.01350","article-title":"Zika virus non-structural protein 4A blocks the RLR-MAVS signaling","volume":"9","author":"Ma","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"9929","DOI":"10.1096\/fj.201900260R","article-title":"Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA","volume":"33","author":"Li","year":"2019","journal-title":"FASEB J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/CVI.00500-13","article-title":"Dengue virus subverts the interferon induction pathway via NS2B\/3 protease-I\u03baB kinase \u03b5 interaction","volume":"21","author":"Pantoja","year":"2014","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e00553-15","DOI":"10.1128\/mBio.00553-15","article-title":"Dengue Virus NS Proteins Inhibit RIG-I\/MAVS Signaling by Blocking TBK1\/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant","volume":"6","author":"Dalrymple","year":"2015","journal-title":"mBio"},{"key":"ref_57","first-page":"1","article-title":"Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro","volume":"3","author":"Wu","year":"2017","journal-title":"Cell Discov."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.virol.2018.11.009","article-title":"Zika virus NS5 protein antagonizes type I interferon production via blocking TBK1 activation","volume":"527","author":"Lin","year":"2019","journal-title":"Virology"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Haddow, A.D., Schuh, A.J., Yasuda, C.Y., Kasper, M.R., Heang, V., Huy, R., Guzman, H., Tesh, R.B., and Weaver, S.C. (2012). Genetic characterization of zika virus strains: Geographic expansion of the asian lineage. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001477"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lundberg, R., Mel\u00e9n, K., Westenius, V., Jiang, M., \u00d6sterlund, P., Khan, H., Vapalahti, O., Julkunen, I., and Kakkola, L. (2019). Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon. Viruses, 11.","DOI":"10.3390\/v11111024"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"15942","DOI":"10.1074\/jbc.M500814200","article-title":"NF-\u03baB is transported into the nucleus by importin \u03b13 and importin \u03b14","volume":"280","author":"Fagerlund","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ye, J., Chen, Z., Li, Y., Zhao, Z., He, W., Zohaib, A., Song, Y., Deng, C., Zhang, B., and Chen, H. (2017). Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-\u03baB. J. Virol., 91.","DOI":"10.1128\/JVI.00039-17"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vetmic.2013.04.026","article-title":"Japanese encephalitis virus non-coding RNA inhibits activation of interferon by blocking nuclear translocation of interferon regulatory factor 3","volume":"166","author":"Chang","year":"2013","journal-title":"Vet. Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nmicrobiol.2017.37","article-title":"Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection","volume":"2","author":"Aguirre","year":"2017","journal-title":"Nat. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"E6310","DOI":"10.1073\/pnas.1803406115","article-title":"Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease","volume":"115","author":"Ding","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Aguirre, S., Maestre, A.M., Pagni, S., Patel, J.R., Savage, T., Gutman, D., Maringer, K., Bernal-Rubio, D., Shabman, R.S., and Simon, V. (2012). DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002934"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Yu, C.-Y., Chang, T.-H., Liang, J.-J., Chiang, R.-L., Lee, Y.-L., Liao, C.-L., and Lin, Y.-L. (2012). Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002780"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e31919","DOI":"10.7554\/eLife.31919","article-title":"Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir","volume":"7","author":"Stabell","year":"2018","journal-title":"eLife"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Sim, S., and Dimopoulos, G. (2010). Dengue virus inhibits immune responses in Aedes aegypti cells. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010678"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Pompon, J., Manuel, M., Ng, G.K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S.S., Ooi, E.E., and Miss\u00e9, D. (2017). Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006535"},{"key":"ref_72","first-page":"1","article-title":"Inhibition of defensin and cecropin responses to dengue virus 1 infection in Aedes aegypti","volume":"41","author":"Pacheco","year":"2020","journal-title":"Biomedica"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"19136","DOI":"10.1073\/pnas.1905617116","article-title":"Subgenomic flavivirus RNA binds the mosquito DEAD\/H-box helicase ME31B and determines Zika virus transmission by Aedes aegypti","volume":"116","author":"Hiralal","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s12192-017-0810-0","article-title":"Participation of dengue virus NS4B protein in the modulation of immune effectors dependent on ER stress in insect cells","volume":"22","year":"2017","journal-title":"Cell Stress Chaperones"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Russell, T.A., Ayaz, A., Davidson, A.D., Fernandez-Sesma, A., and Maringer, K. (2021). Imd pathway-specific immune assays reveal NF-\u03baB stimulation by viral RNA PAMPs in Aedes aegypti Aag2 cells. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0008524"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Kumar, A., Srivastava, P., Sirisena, P.D.N.N., Dubey, S.K., Kumar, R., Shrinet, J., and Sunil, S. (2018). Mosquito innate immunity. Insects, 9.","DOI":"10.3390\/insects9030095"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"16499","DOI":"10.1074\/jbc.M500711200","article-title":"REL1, a homologue of Drosophila dorsal, regulates toll antifungal immune pathway in the female mosquito Aedes aegypti","volume":"280","author":"Sang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-021-03743-5","article-title":"cGAS-like receptors sense RNA and control 3\u20322\u2032-cGAMP signalling in Drosophila","volume":"597","author":"Slavik","year":"2021","journal-title":"Nature"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41586-021-03800-z","article-title":"Two cGAS-like receptors induce antiviral immunity in Drosophila","volume":"597","author":"Holleufer","year":"2021","journal-title":"Nature"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2018.07.013","article-title":"The Kinase IKK\u03b2 Regulates a STING- and NF-\u03baB-Dependent Antiviral Response Pathway in Drosophila","volume":"49","author":"Goto","year":"2018","journal-title":"Immunity"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"eabc4537","DOI":"10.1126\/scisignal.abc4537","article-title":"2\u20323\u2032-cGAMP triggers a STING- And NF-\u03baB-dependent broad antiviral response in Drosophila","volume":"13","author":"Cai","year":"2020","journal-title":"Sci. Signal."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1093\/nar\/gku569","article-title":"Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING","volume":"42","author":"Wu","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1089\/jir.2008.0078","article-title":"Identification of a putative invertebrate helical cytokine similar to the ciliary neurotrophic factor\/Leukemia inhibitory factor family by PSI-BLAST-Based approach","volume":"29","author":"Cheng","year":"2009","journal-title":"J. Interf. Cytokine Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type i interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.immuni.2006.08.014","article-title":"Complex Modulation of Cell Type-Specific Signaling in Response to Type I Interferons","volume":"25","author":"Rani","year":"2006","journal-title":"Immunity"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type i interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e27715","DOI":"10.4161\/jkst.27715","article-title":"STAT2 signaling and dengue virus infection","volume":"3","author":"Morrison","year":"2014","journal-title":"Jak-Stat"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"17841","DOI":"10.1073\/pnas.0905006106","article-title":"An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense","volume":"106","author":"Sim","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"18915","DOI":"10.1073\/pnas.1205231109","article-title":"Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway","volume":"109","author":"Paradkar","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/ni.1664","article-title":"The DExD\/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila","volume":"9","author":"Deddouche","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1074\/jbc.M309749200","article-title":"Characterization of two mosquito STATs, AaSTAT and CtSTAT: Differential regulation of tyrosine phosphorylation and DNA binding activity by lipopolysaccharide treatment and by Japanese encephalitis virus infection","volume":"279","author":"Lin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1128\/JVI.74.11.4957-4966.2000","article-title":"Modulation of Dengue Virus Infection in Human Cells by Alpha, Beta, and Gamma Interferons","volume":"74","author":"Diamond","year":"2000","journal-title":"J. Virol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/095632020401500202","article-title":"Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models","volume":"15","author":"Morrey","year":"2004","journal-title":"Antivir. Chem. Chemother."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embr.201642627","article-title":"Zika virus inhibits type-I interferon production and downstream signaling","volume":"17","author":"Kumar","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.chom.2015.06.007","article-title":"Flavivirus antagonism of type i interferon signaling reveals prolidase as a regulator of IFNAR1 surface expression","volume":"18","author":"Lubick","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"9760","DOI":"10.1128\/JVI.01051-10","article-title":"Inhibition of the Type I Interferon Response in Human Dendritic Cells by Dengue Virus Infection Requires a Catalytically Active NS2B3 Complex","volume":"84","author":"Ashour","year":"2010","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9285","DOI":"10.1128\/JVI.78.17.9285-9294.2004","article-title":"Blocking of the Alpha Interferon-Induced Jak-Stat Signaling Pathway by Japanese Encephalitis Virus Infection","volume":"78","author":"Lin","year":"2004","journal-title":"J. Virol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1128\/JVI.79.9.5414-5420.2005","article-title":"Dengue Virus Inhibits Alpha Interferon Signaling by Reducing STAT2 Expression","volume":"79","author":"Jones","year":"2005","journal-title":"J. Virol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1128\/JVI.02188-08","article-title":"NS5 of Dengue Virus Mediates STAT2 Binding and Degradation","volume":"83","author":"Ashour","year":"2009","journal-title":"J. Virol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1086\/605847","article-title":"Dengue Virus NS5 Inhibits Interferon-\u03b1 Signaling by Blocking Signal Transducer and Activator of Transcription 2 Phosphorylation","volume":"200","author":"Mazzon","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"7120","DOI":"10.1128\/MCB.25.16.7120-7136.2005","article-title":"A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons","volume":"25","author":"Tasaki","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Morrison, J., Laurent-Rolle, M., Maestre, A.M., Rajsbaum, R., Pisanelli, G., Simon, V., Mulder, L.C.F., Fernandez-Sesma, A., and Garc\u00eda-Sastre, A. (2013). Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003265"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/eji.201847483","article-title":"Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling","volume":"48","author":"Hertzog","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1128\/JVI.79.3.1934-1942.2005","article-title":"Inhibition of Interferon Signaling by the New York 99 Strain and Kunjin Subtype of West Nile Virus Involves Blockage of STAT1 and STAT2 Activation by Nonstructural Proteins","volume":"79","author":"Liu","year":"2005","journal-title":"J. Virol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika Virus Targets Human STAT2 to Inhibit Type i Interferon Signaling","volume":"19","author":"Grant","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.chom.2014.07.015","article-title":"The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon","volume":"16","author":"Morrison","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41594-020-0472-y","article-title":"Structural basis for STAT2 suppression by flavivirus NS5","volume":"27","author":"Wang","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.chom.2018.04.003","article-title":"An Immunocompetent Mouse Model of Zika Virus Infection","volume":"23","author":"Gorman","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1099\/jgv.0.001092","article-title":"A single amino acid substitution in the NS4B protein of dengue virus confers enhanced virus growth and fitness in human cells in vitro through IFN-dependent host response","volume":"99","author":"Bui","year":"2018","journal-title":"J. Gen. Virol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Paradkar, P.N., Duchemin, J.B., Rodriguez-Andres, J., Trinidad, L., and Walker, P.J. (2015). Cullin4 Is Pro-Viral during West Nile Virus Infection of Culex Mosquitoes. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1005143"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41577-018-0071-x","article-title":"Small RNA-based antimicrobial immunity","volume":"19","author":"Guo","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2007.07.039","article-title":"Antiviral Immunity Directed by Small RNAs","volume":"130","author":"Ding","year":"2007","journal-title":"Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41422-019-0158-3","article-title":"Anti-Zika virus RNAi in neural progenitor cells","volume":"29","author":"Xie","year":"2019","journal-title":"Cell Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41422-019-0152-9","article-title":"Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids","volume":"29","author":"Xu","year":"2019","journal-title":"Cell Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1126\/science.abg2264","article-title":"An isoform of Dicer protects mammalian stem cells against multiple RNA viruses","volume":"373","author":"Poirier","year":"2021","journal-title":"Science"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2017.11.018","article-title":"Intrinsic Immunity Shapes Viral Resistance of Stem Cells","volume":"172","author":"Wu","year":"2018","journal-title":"Cell"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Schuster, S., Miesen, P., and van Rij, R.P. (2019). Antiviral RNAi in insects and mammals: Parallels and differences. Viruses, 11.","DOI":"10.3390\/v11050448"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.15252\/embj.201695086","article-title":"Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells","volume":"35","author":"Maillard","year":"2016","journal-title":"EMBO J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e97479","DOI":"10.15252\/embj.201797479","article-title":"The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells","volume":"37","author":"Veen","year":"2018","journal-title":"EMBO J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika Virus and Birth Defects\u2014Reviewing the Evidence for Causality","volume":"374","author":"Rasmussen","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","article-title":"Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure","volume":"165","author":"Qian","year":"2016","journal-title":"Cell"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Zeng, J., Dong, S., Luo, Z., Xie, X., Fu, B., Li, P., Liu, C., Yang, X., Chen, Y., and Wang, X. (2020). The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell.","DOI":"10.1016\/j.stem.2020.07.012"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.aax7989","article-title":"Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes","volume":"6","author":"Qiu","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"8870","DOI":"10.1128\/JVI.02774-12","article-title":"Role of RNA Interference (RNAi) in Dengue Virus Replication and Identification of NS4B as an RNAi Suppressor","volume":"87","author":"Kakumani","year":"2013","journal-title":"J. Virol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"13486","DOI":"10.1128\/JVI.01104-12","article-title":"Noncoding Flavivirus RNA Displays RNA Interference Suppressor Activity in Insect and Mammalian Cells","volume":"86","author":"Schnettler","year":"2012","journal-title":"J. Virol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.virol.2015.08.009","article-title":"Flavivirus sfRNA suppresses antiviral RNA interference in cultured cells and mosquitoes and directly interacts with the RNAi machinery","volume":"485","author":"Moon","year":"2015","journal-title":"Virology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cois.2015.01.006","article-title":"RNA interference-mediated antiviral defense in insects","volume":"8","author":"Gammon","year":"2015","journal-title":"Curr. Opin. Insect Sci."},{"key":"ref_130","first-page":"183","article-title":"RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates","volume":"371","author":"Nayak","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"13863","DOI":"10.1073\/pnas.1600544113","article-title":"Yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double-stranded RNA","volume":"113","author":"Samuel","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"10145","DOI":"10.1128\/JVI.00930-16","article-title":"Noncoding Subgenomic Flavivirus RNA Is Processed by the Mosquito RNA Interference Machinery and Determines West Nile Virus Transmission by Culex pipiens Mosquitoes","volume":"90","author":"Fros","year":"2016","journal-title":"J. Virol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-16086-y","article-title":"Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes","volume":"11","author":"Slonchak","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Varjak, M., Donald, C.L., Mottram, T.J., Sreenu, V.B., Merits, A., Maringer, K., Schnettler, E., and Kohl, A. (2017). Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0006010"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/11\/2116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:19:41Z","timestamp":1760167181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/11\/2116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":134,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["v13112116"],"URL":"https:\/\/doi.org\/10.3390\/v13112116","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,20]]}}}