{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:14:26Z","timestamp":1792588466672,"version":"4.5.0"},"reference-count":37,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["00000"],"award-info":[{"award-number":["00000"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["0000000"],"award-info":[{"award-number":["0000000"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["0000"],"award-info":[{"award-number":["0000"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Mayaro virus (MAYV) is a neglected arthropod-borne virus found in the Americas. MAYV infection results in Mayaro fever, a non-lethal debilitating disease characterized by a strong inflammatory response affecting the joints and muscles. MAYV was once considered endemic to forested areas in Brazil but has managed to adapt and spread to urban regions using new vectors, such as Aedes aegypti, and has the potential to cause serious epidemics in the future. Currently, there are no vaccines or specific treatments against MAYV. In this study, the antiviral activity of a series of synthetic cyclic ketones were evaluated for the first time against MAYV. Twenty-four compounds were screened in a cell viability assay, and eight were selected for further evaluation. Effective concentration (EC50) and selectivity index (SI) were calculated and compound 9-(5-(4-chlorophenyl]furan-2-yl)-3,6-dimethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2))-dione (9) (EC50 = 21.5 \u00b5mol\u00b7L\u22121, SI = 15.8) was selected for mechanism of action assays. The substance was able to reduce viral activity by approximately 70% in both pre-treatment and post-treatment assays.<\/jats:p>","DOI":"10.3390\/v13112123","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T23:27:39Z","timestamp":1634858859000},"page":"2123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4327-9454","authenticated-orcid":false,"given":"Luciana S.","family":"Fernandes","sequence":"first","affiliation":[{"name":"Molecular Immunovirology Laboratory, General Biology Department, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milene L.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Microbiology Department, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9752-1969","authenticated-orcid":false,"given":"Roberto S.","family":"Dias","sequence":"additional","affiliation":[{"name":"Molecular Immunovirology Laboratory, General Biology Department, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-7798","authenticated-orcid":false,"given":"Marcel S.","family":"da S. Lucindo","sequence":"additional","affiliation":[{"name":"Molecular Immunovirology Laboratory, General Biology Department, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cdtalo E. P.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Molecular Immunovirology Laboratory, General Biology Department, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia C.","family":"Silva","sequence":"additional","affiliation":[{"name":"Microbiology Department, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3181-1108","authenticated-orcid":false,"given":"R\u00f3bson R.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Chemistry Department, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2275-5768","authenticated-orcid":false,"given":"S\u00e9rgio O.","family":"de Paula","sequence":"additional","affiliation":[{"name":"Molecular Immunovirology Laboratory, General Biology Department, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1590\/0037-8682-0246-2014","article-title":"Review Article Emerging alphaviruses in the Americas: Chikungunya and Mayaro","volume":"47","author":"Figueiredo","year":"2014","journal-title":"Rev. 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