{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:55:08Z","timestamp":1790034908204,"version":"4.0.1"},"reference-count":52,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Many studies have investigated post-COVID symptoms, but the predictors of symptom persistence remain unknown. The objective was to describe the natural course of the disease at 6 months and to identify possible factors favoring the resurgence or persistence of these symptoms. COVEVOL is a retrospective observational descriptive study of 74 patients. All patients with positive SARS-CoV-2 PCR from March 2020 were included. We compared a group with symptom persistence (PS group) with another group without symptom persistence (no-PS group). Fifty-three out of seventy-four patients (71.62%) described at least one persistent symptom at 6 months of SARS-CoV-2 infection. In the PS group, 56.6% were women and the average age was 54.7 years old [21\u201389.2] \u00b1 16.9. The main symptoms were asthenia (56.6%, n = 30), dyspnea (34%, n = 18), anxiety (32.1% n = 17), anosmia (24.5%, n = 13) and agueusia (15.1% n = 8). Ten patients (13.51%) presented a resurgence in symptoms. Patients in the PS group were older (p = 0.0048), had a higher BMI (p = 0.0071), and were more frequently hospitalized (p = 0.0359) compared to the no-PS group. Odynophagia and nasal obstruction were less present in the inaugural symptoms of COVID-19 in the PS group (p = 0.0202 and p = 0.0332). Persistent post-COVID syndromes are common and identification of contributing factors is necessary for understanding this phenomenon and appropriate management.<\/jats:p>","DOI":"10.3390\/v13112151","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T21:44:31Z","timestamp":1635198271000},"page":"2151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["COVEVOL: Natural Evolution at 6 Months of COVID-19"],"prefix":"10.3390","volume":"13","author":[{"given":"Louise","family":"Messin","sequence":"first","affiliation":[{"name":"Infectious Disease Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Puyraveau","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, Jean Minjoz University Hospital of Besan\u00e7on, 25000 Besancon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousri","family":"Benabdallah","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Lepiller","sequence":"additional","affiliation":[{"name":"Virology Department, Jean Minjoz University Hospital of Besan\u00e7on, 25000 Besancon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9220-9359","authenticated-orcid":false,"given":"Vincent","family":"Gendrin","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-9806","authenticated-orcid":false,"given":"Souheil","family":"Zayet","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timoth\u00e9e","family":"Klopfenstein","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Toko","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Pierron","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Royer","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jare.2020.03.005","article-title":"COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses","volume":"24","author":"Shereen","year":"2020","journal-title":"J. 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