{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:45:04Z","timestamp":1787906704984,"version":"build-2784847793"},"reference-count":110,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Although there have been documented Ebola virus disease outbreaks for more than 40 years, the natural reservoir host has not been identified. Recent studies provide evidence that the Angolan free-tailed bat (Mops condylurus), an insectivorous microbat, is a possible ebolavirus reservoir. To investigate the potential role of this bat species in the ecology of ebolaviruses, replication, tolerance, and persistence of Ebola virus (EBOV) were investigated in 10 different primary bat cell isolates from M. condylurus. Varying EBOV replication kinetics corresponded to the expression levels of the integral membrane protein NPC1. All primary cells were highly tolerant to EBOV infection without cytopathic effects. The observed persistent EBOV infection for 150 days in lung primary cells, without resultant selective pressure leading to virus mutation, indicate the intrinsic ability of EBOV to persist in this bat species. These results provide further evidence for this bat species to be a likely reservoir of ebolaviruses.<\/jats:p>","DOI":"10.3390\/v13112186","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T22:14:52Z","timestamp":1635891292000},"page":"2186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Tolerance and Persistence of Ebola Virus in Primary Cells from Mops condylurus, a Potential Ebola Virus Reservoir"],"prefix":"10.3390","volume":"13","author":[{"given":"Marcel","family":"Bokelmann","sequence":"first","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Vogel","sequence":"additional","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franka","family":"Debeljak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, King\u2019s College London, London WC2R 2LS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"D\u00fcx","sequence":"additional","affiliation":[{"name":"Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-0550","authenticated-orcid":false,"given":"Silke","family":"Riesle-Sbarbaro","sequence":"additional","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Lander","sequence":"additional","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Wahlbrink","sequence":"additional","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kromarek","sequence":"additional","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Neil","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, King\u2019s College London, London WC2R 2LS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Couacy-Hymann","sequence":"additional","affiliation":[{"name":"Laboratoire National d\u2019Appui au D\u00e9veloppement Agricole, Bingerville BP 206, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Prescott","sequence":"additional","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9660-9878","authenticated-orcid":false,"given":"Andreas","family":"Kurth","sequence":"additional","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (2020, June 24). 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